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The map label for this gene is luxS [H]

Identifier: 94994854

GI number: 94994854

Start: 1393821

End: 1394393

Strand: Direct

Name: luxS [H]

Synonym: MGAS10750_Spy1458

Alternate gene names: 94994854

Gene position: 1393821-1394393 (Clockwise)

Preceding gene: 94994853

Following gene: 94994859

Centisome position: 71.95

GC content: 39.62

Gene sequence:

>573_bases
TTGATCTGTTTTCTTAGCCTTTTCTCCTCCACAAGTAGCCACTTTCTCACTATTTGTGTTATGATAAAGTGTAAAACAAA
GGAGATTGAAATGACAAAAGAAGTTATCGTCGAAAGTTTTGAGCTAGATCATACTATTGTAAAGGCCCCTTATGTTCGTC
TTATTTCTGAAGAATTTGGACCCAAGGGCGATCGTATTACAAATTTTGATGTTCGCCTAGTACAGCCTAACCAAAATTCT
ATTGAAACAGCCGGTTTGCATACCATTGAACACTTACTTGCCAAGCTCATCCGCCAACGCATTGATGGGATGATTGATTG
CTCTCCTTTTGGCTGTCGAACAGGTTTTCACCTTATCATGTGGGGAAAACACAGTTCTACTGATATTGCCAAGGTGATTA
AATCTAGCCTAGAAGAAATTGCAACTGGGATTACTTGGGAAGATGTTCCTGGAACAACTCTTGAATCCTGTGGAAACTAT
AAGGATCATAACCTTTTTGCCGCCAAAGAATGGGCTCAATTGATTATTGATCAAGGGATTTCAGACGATCCTTTTAGTCG
CCATGTCATCTGA

Upstream 100 bases:

>100_bases
TTCTTAGCATTGACAGGACTTAACCACAAAAATGCTTTTAAAGAAACCTTTATTACTGTTTCTGTAAGTACTTTTATCGC
ACAGGTCATTGTGATAGCCT

Downstream 100 bases:

>100_bases
TACTAGTGTGTTGTCAAACATAACAATCCTACTGACCTATTTGACTTGTTACAAAAAACAAGTCTATCTGCAGATTTTAA
GACAACATACTTTATTAATC

Product: S-ribosylhomocysteinase

Products: NA

Alternate protein names: AI-2 synthesis protein; Autoinducer-2 production protein luxS [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MICFLSLFSSTSSHFLTICVMIKCKTKEIEMTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNS
IETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTLESCGNY
KDHNLFAAKEWAQLIIDQGISDDPFSRHVI

Sequences:

>Translated_190_residues
MICFLSLFSSTSSHFLTICVMIKCKTKEIEMTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNS
IETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTLESCGNY
KDHNLFAAKEWAQLIIDQGISDDPFSRHVI
>Mature_190_residues
MICFLSLFSSTSSHFLTICVMIKCKTKEIEMTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNS
IETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTLESCGNY
KDHNLFAAKEWAQLIIDQGISDDPFSRHVI

Specific function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is ca

COG id: COG1854

COG function: function code T; LuxS protein involved in autoinducer AI2 synthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the luxS family [H]

Homologues:

Organism=Escherichia coli, GI1789043, Length=149, Percent_Identity=34.2281879194631, Blast_Score=106, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR003815
- ProDom:   PD013172 [H]

Pfam domain/function: PF02664 LuxS [H]

EC number: =4.4.1.21 [H]

Molecular weight: Translated: 21429; Mature: 21429

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICFLSLFSSTSSHFLTICVMIKCKTKEIEMTKEVIVESFELDHTIVKAPYVRLISEEFG
CEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
PKGDRITNFDVRLVQPNQNSIETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIM
CCCCCEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCEEEE
WGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTLESCGNYKDHNLFAAKEWAQLIIDQGI
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCC
SDDPFSRHVI
CCCCCCCCCC
>Mature Secondary Structure
MICFLSLFSSTSSHFLTICVMIKCKTKEIEMTKEVIVESFELDHTIVKAPYVRLISEEFG
CEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
PKGDRITNFDVRLVQPNQNSIETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIM
CCCCCEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCEEEE
WGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTLESCGNYKDHNLFAAKEWAQLIIDQGI
ECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCC
SDDPFSRHVI
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA