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The map label for this gene is atoB [H]

Identifier: 94994849

GI number: 94994849

Start: 1389101

End: 1390288

Strand: Direct

Name: atoB [H]

Synonym: MGAS10750_Spy1453

Alternate gene names: 94994849

Gene position: 1389101-1390288 (Clockwise)

Preceding gene: 94994834

Following gene: 94994850

Centisome position: 71.71

GC content: 41.75

Gene sequence:

>1188_bases
ATGAAAAACATAGTTATCGTTGAAGCTTTACGAACTCCTATCGGAGCTTTTGGAGGCTCCTTTAAAAGTGTCTCTGCTGT
TGAACTTGGAACAACTGTACTGAAAAAAATCCTTGATAAAACGCAAGTAAAGCCTGAAATGGTTGATGAAGTCATCCTAG
GAAACGTCCTTCATGCAGGATTAGGGCAAAACGTTGCCAGACAGATTGCTATTCACTCTGGCATCCCTAGTGATAAAACA
GCCTTCACGCTTGATATGGTCTGTGGTTCAGGACTTAAAGCAATCCAATTAGCTACGCAAAGCATCATGCTTGGTGACGC
TGATATCGTTATTGCTGGTGGTGTCGAAAACATGTCACAGGCAGCCTATGTGTCAACTCAGCACCGTTTTGGACAGCGAC
TTGGTAATAGTCAATTGATTGATACTCTTGTTCATGATGGATTGACAGATGCTTTCAACAATTATCATATGGGTATCACT
GCTGAAAACGTTGCTCAGAAATATGGCATCTCAAGAGAAGAGCAAGATCAATTTGCTTTAGAAAGCCAAGAAAAAGCTGC
TAAGGCATTAGAAAATCATCGTTTTGCTGACGAAATTGTCCCTGTCTCTGTGCCTCAACGACGCAAAGACCCTTTAATTG
TTACAACAGATGAATACCCAAAAGTTGACACAAGCCTTGAAAAATTACAGCAATTACGTCCTGCCTTCCTCCCTAAAGAA
GGAACCGTTACTGCTGGGAATGCCTCAGGAATAAACGATGGTGCAGCCTTATTGATGTTAATGACTGAAGAAAAAGCTCT
TGAATTAGGGTTAACACCTTTAGTCACTATTGAAAGCTATGCTAGTGCAGGTGTTGCACCTGAACTGATGGGAGCTGGAC
CAATTCCTGCCACTCAAAAAGTCCTTAAGAAAGCTGGATTAACAATTTCTGATTTGGACTTAGTGGAGTCCAATGAAGCA
TTTGCAGCACAGTCCTTGGCGGTTTTAAAAGATTTAAAGTTAAACCCAGAAATCGTGAATGTTAATGGAGGAGCCATCGC
TTTAGGTCATCCTATTGGTGCCAGTGGCGCTCGCATTCTAGTCACATTAATCCACGAAATGAAAAAACGCCAAGTAACCA
GAGGACTAGCAACACTTTGCATTGGTGGAGGACAAGGAACTGCTGTTATCGTGAAAAACAATACTTAG

Upstream 100 bases:

>100_bases
TTTATATGCTTATAAAAATTCTATATTTTTATTTTGAGCGGTTTCTTGTTATCTTAGAGATACAGAAAACGCTTTCTAAA
AATGAAAGGATGTTTATTTT

Downstream 100 bases:

>100_bases
TCTCGTGAAAGTTGGTAGAAAAAATGTGTAAAGAAATCACAATAAAAGAAGCGGTAGCTCACGTTAAAGATGGTGATACC
ATTATGGTTGGTGGCTTCAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKNIVIVEALRTPIGAFGGSFKSVSAVELGTTVLKKILDKTQVKPEMVDEVILGNVLHAGLGQNVARQIAIHSGIPSDKT
AFTLDMVCGSGLKAIQLATQSIMLGDADIVIAGGVENMSQAAYVSTQHRFGQRLGNSQLIDTLVHDGLTDAFNNYHMGIT
AENVAQKYGISREEQDQFALESQEKAAKALENHRFADEIVPVSVPQRRKDPLIVTTDEYPKVDTSLEKLQQLRPAFLPKE
GTVTAGNASGINDGAALLMLMTEEKALELGLTPLVTIESYASAGVAPELMGAGPIPATQKVLKKAGLTISDLDLVESNEA
FAAQSLAVLKDLKLNPEIVNVNGGAIALGHPIGASGARILVTLIHEMKKRQVTRGLATLCIGGGQGTAVIVKNNT

Sequences:

>Translated_395_residues
MKNIVIVEALRTPIGAFGGSFKSVSAVELGTTVLKKILDKTQVKPEMVDEVILGNVLHAGLGQNVARQIAIHSGIPSDKT
AFTLDMVCGSGLKAIQLATQSIMLGDADIVIAGGVENMSQAAYVSTQHRFGQRLGNSQLIDTLVHDGLTDAFNNYHMGIT
AENVAQKYGISREEQDQFALESQEKAAKALENHRFADEIVPVSVPQRRKDPLIVTTDEYPKVDTSLEKLQQLRPAFLPKE
GTVTAGNASGINDGAALLMLMTEEKALELGLTPLVTIESYASAGVAPELMGAGPIPATQKVLKKAGLTISDLDLVESNEA
FAAQSLAVLKDLKLNPEIVNVNGGAIALGHPIGASGARILVTLIHEMKKRQVTRGLATLCIGGGQGTAVIVKNNT
>Mature_395_residues
MKNIVIVEALRTPIGAFGGSFKSVSAVELGTTVLKKILDKTQVKPEMVDEVILGNVLHAGLGQNVARQIAIHSGIPSDKT
AFTLDMVCGSGLKAIQLATQSIMLGDADIVIAGGVENMSQAAYVSTQHRFGQRLGNSQLIDTLVHDGLTDAFNNYHMGIT
AENVAQKYGISREEQDQFALESQEKAAKALENHRFADEIVPVSVPQRRKDPLIVTTDEYPKVDTSLEKLQQLRPAFLPKE
GTVTAGNASGINDGAALLMLMTEEKALELGLTPLVTIESYASAGVAPELMGAGPIPATQKVLKKAGLTISDLDLVESNEA
FAAQSLAVLKDLKLNPEIVNVNGGAIALGHPIGASGARILVTLIHEMKKRQVTRGLATLCIGGGQGTAVIVKNNT

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=52.0512820512821, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=43.6548223350254, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.2569974554707, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=41.1616161616162, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI4504327, Length=433, Percent_Identity=35.3348729792148, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.3775510204082, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI19923233, Length=404, Percent_Identity=26.2376237623762, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=58.3756345177665, Blast_Score=453, Evalue=1e-129,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=59.0330788804071, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=43.5643564356436, Blast_Score=310, Evalue=7e-86,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=40.9876543209877, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=33.0097087378641, Blast_Score=214, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=43.1122448979592, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=42.4936386768448, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=40.7594936708861, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=31.6901408450704, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.0610687022901, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=43.7185929648241, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=38.1546134663342, Blast_Score=243, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=48.9795918367347, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=44.2748091603053, Blast_Score=322, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.8205128205128, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=33.1786542923434, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41785; Mature: 41785

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIVIVEALRTPIGAFGGSFKSVSAVELGTTVLKKILDKTQVKPEMVDEVILGNVLHAG
CCCEEEEHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGQNVARQIAIHSGIPSDKTAFTLDMVCGSGLKAIQLATQSIMLGDADIVIAGGVENMSQ
CCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHEECCCCEEEECCCCCHHH
AAYVSTQHRFGQRLGNSQLIDTLVHDGLTDAFNNYHMGITAENVAQKYGISREEQDQFAL
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHCCCCCHHHHHHH
ESQEKAAKALENHRFADEIVPVSVPQRRKDPLIVTTDEYPKVDTSLEKLQQLRPAFLPKE
HHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
GTVTAGNASGINDGAALLMLMTEEKALELGLTPLVTIESYASAGVAPELMGAGPIPATQK
CEEECCCCCCCCCCEEEEEEEECHHHHHHCCCCEEEEHHHHCCCCCHHHHCCCCCCHHHH
VLKKAGLTISDLDLVESNEAFAAQSLAVLKDLKLNPEIVNVNGGAIALGHPIGASGARIL
HHHHHCCEEEECHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCHHHHH
VTLIHEMKKRQVTRGLATLCIGGGQGTAVIVKNNT
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCC
>Mature Secondary Structure
MKNIVIVEALRTPIGAFGGSFKSVSAVELGTTVLKKILDKTQVKPEMVDEVILGNVLHAG
CCCEEEEHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGQNVARQIAIHSGIPSDKTAFTLDMVCGSGLKAIQLATQSIMLGDADIVIAGGVENMSQ
CCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHEECCCCEEEECCCCCHHH
AAYVSTQHRFGQRLGNSQLIDTLVHDGLTDAFNNYHMGITAENVAQKYGISREEQDQFAL
HHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHCCCCCHHHHHHH
ESQEKAAKALENHRFADEIVPVSVPQRRKDPLIVTTDEYPKVDTSLEKLQQLRPAFLPKE
HHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
GTVTAGNASGINDGAALLMLMTEEKALELGLTPLVTIESYASAGVAPELMGAGPIPATQK
CEEECCCCCCCCCCEEEEEEEECHHHHHHCCCCEEEEHHHHCCCCCHHHHCCCCCCHHHH
VLKKAGLTISDLDLVESNEAFAAQSLAVLKDLKLNPEIVNVNGGAIALGHPIGASGARIL
HHHHHCCEEEECHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCHHHHH
VTLIHEMKKRQVTRGLATLCIGGGQGTAVIVKNNT
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA