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The map label for this gene is cysM [H]

Identifier: 94994834

GI number: 94994834

Start: 1372537

End: 1373478

Strand: Direct

Name: cysM [H]

Synonym: MGAS10750_Spy1438

Alternate gene names: 94994834

Gene position: 1372537-1373478 (Clockwise)

Preceding gene: 94994833

Following gene: 94994849

Centisome position: 70.85

GC content: 39.92

Gene sequence:

>942_bases
ATGACTAAAATTTACAAAACTATAACAGAATTAGTAGGTCAGACACCTATTATCAAACTTAACCGTTTAATTCCAAACGA
AGCTGCTGACGTTTATGTAAAATTAGAAGCTTTTAACCCAGGATCTTCTGTTAAAGATCGTATTGCTTTATCGATGATTG
AAGCTGCTGAAGCTGAAGGTCTGATAAGTCCTGGTGACGTTATTATCGAACCAACGAGCGGTAATACAGGTATTGGTCTT
GCATGGGTAGGTGCTGCTAAAGGGTATCGAGTCATTATTGTTATGCCCGAAACGATGAGCTTGGAAAGACGACAAATCAT
TCAGGCTTATGGTGCAGAGCTTGTCTTAACACCTGGAGCAGAAGGTATGAAAGGGGCTATTGCAAAAGCTGAAACTTTAG
CAATAGAACTAGGTGCTTGGATGCCTATGCAATTTAATAACCCTGCCAATCCAAGCATCCATGAAAAAACAACAGCTCAA
GAAATTTTGGAAGCTTTTAAGGAGATTTCTTTAGATGCATTCGTATCTGGTGTTGGTACTGGAGGAACACTTTCTGGTGT
TTCACATGTCTTGAAAAAAGCTAGCCCTGAAACTGCTATCTATGCTGTTGAAGCTGAAGAATCTGCTGTCTTATCTGGTC
AAGAGCCTGGACCACATAAAATCCAAGGTATATCAGCTGGATTTATCCCAAACACGTTAGATACCAAAGCCTATGACCAA
ATTATCCGTGTTAAATCGAAAGATGCTTTAGAAACTGCTCGACTAACAGGAGCTAAGGAAGGCTTCCTGGTTGGGATTTC
TTCTGGAGCTGCTCTTTACGCCGCTATTGAAGTCGCTAAACAGTTAGGAAAAGGCAAACATGTGTTAACTATTTTACCAG
ATAATGGCGAACGCTATTTATCGACTGAACTCTATGATGTACCAGTAATTAAGACGAAATAA

Upstream 100 bases:

>100_bases
TATCAGAGTGATAGTAAATCTGTATTTTACTTTAATAATATCTCTCCTTATACTTAAATACACAGCGTATTTATTTTGTA
TCAAGAAAAGAGGCTAAACT

Downstream 100 bases:

>100_bases
AAAAGGGTTTGGAACTACTAAGGTTCCAGACTCTTTTTAGTGTTCTTTTTTAAAAACTGCAGGCTTTCTTCAATCCACTG
AGGTAACTGCTCTTCAAGTG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTKIYKTITELVGQTPIIKLNRLIPNEAADVYVKLEAFNPGSSVKDRIALSMIEAAEAEGLISPGDVIIEPTSGNTGIGL
AWVGAAKGYRVIIVMPETMSLERRQIIQAYGAELVLTPGAEGMKGAIAKAETLAIELGAWMPMQFNNPANPSIHEKTTAQ
EILEAFKEISLDAFVSGVGTGGTLSGVSHVLKKASPETAIYAVEAEESAVLSGQEPGPHKIQGISAGFIPNTLDTKAYDQ
IIRVKSKDALETARLTGAKEGFLVGISSGAALYAAIEVAKQLGKGKHVLTILPDNGERYLSTELYDVPVIKTK

Sequences:

>Translated_313_residues
MTKIYKTITELVGQTPIIKLNRLIPNEAADVYVKLEAFNPGSSVKDRIALSMIEAAEAEGLISPGDVIIEPTSGNTGIGL
AWVGAAKGYRVIIVMPETMSLERRQIIQAYGAELVLTPGAEGMKGAIAKAETLAIELGAWMPMQFNNPANPSIHEKTTAQ
EILEAFKEISLDAFVSGVGTGGTLSGVSHVLKKASPETAIYAVEAEESAVLSGQEPGPHKIQGISAGFIPNTLDTKAYDQ
IIRVKSKDALETARLTGAKEGFLVGISSGAALYAAIEVAKQLGKGKHVLTILPDNGERYLSTELYDVPVIKTK
>Mature_312_residues
TKIYKTITELVGQTPIIKLNRLIPNEAADVYVKLEAFNPGSSVKDRIALSMIEAAEAEGLISPGDVIIEPTSGNTGIGLA
WVGAAKGYRVIIVMPETMSLERRQIIQAYGAELVLTPGAEGMKGAIAKAETLAIELGAWMPMQFNNPANPSIHEKTTAQE
ILEAFKEISLDAFVSGVGTGGTLSGVSHVLKKASPETAIYAVEAEESAVLSGQEPGPHKIQGISAGFIPNTLDTKAYDQI
IRVKSKDALETARLTGAKEGFLVGISSGAALYAAIEVAKQLGKGKHVLTILPDNGERYLSTELYDVPVIKTK

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=39.3650793650794, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=39.3650793650794, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=39.3650793650794, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=49.0625, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=40.8026755852843, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=47.4916387959866, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI115535073, Length=298, Percent_Identity=50.3355704697987, Blast_Score=254, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=47.1571906354515, Blast_Score=254, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=46.9387755102041, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=45.1505016722408, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=46.9483568075117, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=37.1875, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=36.1635220125786, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=44.8275862068966, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=336, Percent_Identity=26.4880952380952, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=39.0625, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=32, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=37.7777777777778, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=37.7777777777778, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33186; Mature: 33054

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIYKTITELVGQTPIIKLNRLIPNEAADVYVKLEAFNPGSSVKDRIALSMIEAAEAEG
CCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCC
LISPGDVIIEPTSGNTGIGLAWVGAAKGYRVIIVMPETMSLERRQIIQAYGAELVLTPGA
CCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCC
EGMKGAIAKAETLAIELGAWMPMQFNNPANPSIHEKTTAQEILEAFKEISLDAFVSGVGT
CCCHHHHHHHEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCC
GGTLSGVSHVLKKASPETAIYAVEAEESAVLSGQEPGPHKIQGISAGFIPNTLDTKAYDQ
CCHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHH
IIRVKSKDALETARLTGAKEGFLVGISSGAALYAAIEVAKQLGKGKHVLTILPDNGERYL
HHHHCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEE
STELYDVPVIKTK
EEEEEECCEEECC
>Mature Secondary Structure 
TKIYKTITELVGQTPIIKLNRLIPNEAADVYVKLEAFNPGSSVKDRIALSMIEAAEAEG
CHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCC
LISPGDVIIEPTSGNTGIGLAWVGAAKGYRVIIVMPETMSLERRQIIQAYGAELVLTPGA
CCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCC
EGMKGAIAKAETLAIELGAWMPMQFNNPANPSIHEKTTAQEILEAFKEISLDAFVSGVGT
CCCHHHHHHHEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCC
GGTLSGVSHVLKKASPETAIYAVEAEESAVLSGQEPGPHKIQGISAGFIPNTLDTKAYDQ
CCHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHH
IIRVKSKDALETARLTGAKEGFLVGISSGAALYAAIEVAKQLGKGKHVLTILPDNGERYL
HHHHCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEE
STELYDVPVIKTK
EEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA