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The map label for this gene is aroB [H]

Identifier: 94994803

GI number: 94994803

Start: 1331092

End: 1332180

Strand: Direct

Name: aroB [H]

Synonym: MGAS10750_Spy1407

Alternate gene names: 94994803

Gene position: 1331092-1332180 (Clockwise)

Preceding gene: 94994802

Following gene: 94994816

Centisome position: 68.72

GC content: 42.15

Gene sequence:

>1089_bases
ATGAAAGGAGTGCTTATGCCACAAACACTTCATGTCCATTCTCGGGTCAAGGATTATGATATCCTGTTTACCGACCATGT
TTTAAAAACCTTAGCAGATTGCCTTGGTGAGCGCAAGCAGCGTAAACTCTTGTTTATCACCGATCAAACGGTCTACCACT
TGTATCAGACTCTCTTTGAAGAATTTGCTCAGCAATACAACGCTTTTGTCCATGTCTGCCCCCCGGGAGGTCAATCCAAA
TCCTTGGAACGTGTCAGTGCTATCTACGACCAGCTCATCGCTGAAAATTTTTCCAAAAAAGATATGATTGTTACTATTGG
TGGTGGTGTTGTTGGGGATCTGGGTGGTTTTGTCGCTGCAACCTATTACCGTGGTATTCCCTACATTCAAATCCCAACGA
CTTTACTTAGTCAGGTGGATAGCAGTATCGGGGGCAAAGTTGGAGTCCATTTTAAAAGTCTAACCAATATGATTGGCAGC
ATTTACCCTCCAGAAGCTGTCATTATTTCAACCACCTTTTTGGAAACCTTACCGCAACGGGAATTCTCCTGCGGCATCAG
TGAGATGCTCAAAATCGGCTTCATTCATGATAGACCGCTTTTTCAGCAGTTACGTGATTTTCAAAAAGAAACCGATAAGC
AGGGACTTGAACGTCTGATTTACCAATCCATTTCCAATAAAAAACGGATTGTTGAACAAGATGAATTTGAAAATGGTTTG
CGCATGTCTTTAAATTTTGGGCATACCTTGGGCCACGCGATTGAATCGCTCTGTCACCATGATTTTTACCATCACGGTGA
AGCCATTGCTATCGGTATGGTGGTTGATGCTAAACTGGCTGTTTCCAAAGGACTCTTGCCAAAAGAGGACTTGGATAGCC
TCCTTCAAGTTTTTGAACGTTACCAGTTACCAACAACACTTGAAAGAGCTGATGTCTCTGCGACATCCCTCTTTGACGTC
TTTAAAACAGATAAGAAGAATTCTGAGCAACATATTATCTTTATATTACCCACAGAAACCGGTTTTACCACCCTAGCCAT
TAACAAAGACGATCACCAATTTGTCGAGAAGCTCGACAGTTTATTATAA

Upstream 100 bases:

>100_bases
GCCCAGCAAATTGATTATAAGCAATTAGAACAGTTGGGGCAGGAACTTTGGCAAGATTAAGCTCTAAATATCACTGCGTT
ATCTCTGTTACCTAGTACTG

Downstream 100 bases:

>100_bases
ATAGTGACTCCACTCTAGCTAGTTAAGCTTGCTAAGAGAATAACGGTATCCTGGAACTCCTAAAACATGTTACTACAAGA
CAAGTCTTGATAACAATATA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKGVLMPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQYNAFVHVCPPGGQSK
SLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKSLTNMIGS
IYPPEAVIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGL
RMSLNFGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDV
FKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL

Sequences:

>Translated_362_residues
MKGVLMPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQYNAFVHVCPPGGQSK
SLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKSLTNMIGS
IYPPEAVIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGL
RMSLNFGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDV
FKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL
>Mature_362_residues
MKGVLMPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFEEFAQQYNAFVHVCPPGGQSK
SLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAATYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKSLTNMIGS
IYPPEAVIISTTFLETLPQREFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGL
RMSLNFGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFERYQLPTTLERADVSATSLFDV
FKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDSLL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=330, Percent_Identity=34.8484848484849, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320332, Length=286, Percent_Identity=34.2657342657343, Blast_Score=160, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037 [H]

Pfam domain/function: PF01761 DHQ_synthase [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 40904; Mature: 40904

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVLMPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFE
CCCCCCCHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
EFAQQYNAFVHVCPPGGQSKSLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAA
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHH
TYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKSLTNMIGSIYPPEAVIISTTFLETLPQR
HHHCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHCCH
EFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGL
HHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCC
RMSLNFGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFER
EEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHH
YQLPTTLERADVSATSLFDVFKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDS
HCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHH
LL
CC
>Mature Secondary Structure
MKGVLMPQTLHVHSRVKDYDILFTDHVLKTLADCLGERKQRKLLFITDQTVYHLYQTLFE
CCCCCCCHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
EFAQQYNAFVHVCPPGGQSKSLERVSAIYDQLIAENFSKKDMIVTIGGGVVGDLGGFVAA
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHH
TYYRGIPYIQIPTTLLSQVDSSIGGKVGVHFKSLTNMIGSIYPPEAVIISTTFLETLPQR
HHHCCCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHCCH
EFSCGISEMLKIGFIHDRPLFQQLRDFQKETDKQGLERLIYQSISNKKRIVEQDEFENGL
HHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCC
RMSLNFGHTLGHAIESLCHHDFYHHGEAIAIGMVVDAKLAVSKGLLPKEDLDSLLQVFER
EEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHH
YQLPTTLERADVSATSLFDVFKTDKKNSEQHIIFILPTETGFTTLAINKDDHQFVEKLDS
HCCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHH
LL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]