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The map label for this gene is oadA1 [H]

Identifier: 94994455

GI number: 94994455

Start: 1001277

End: 1002689

Strand: Direct

Name: oadA1 [H]

Synonym: MGAS10750_Spy1059

Alternate gene names: 94994455

Gene position: 1001277-1002689 (Clockwise)

Preceding gene: 94994454

Following gene: 94994459

Centisome position: 51.69

GC content: 42.68

Gene sequence:

>1413_bases
TTGATGAGGAGAACAATTATGACGAAAATCCGTATAACGGAAACAGTTTTACGTGATGGTCAACAAAGTCAGATTGCCAC
ACGTATGACAACCAAGGAAATGATTCCTATTCTCGAAACGCTAGACAATGCTGGTTATCATGCCCTTGAAATGTGGGGAG
GAGCAACCTTTGATTCCTGCCTACGCTTTTTAAATGAAGACCCTTGGGAACGGCTAAGAGCCATCCGTAAAGCAGTGAAA
AAGACTAAACTTCAGATGCTCTTACGCGGACAAAACCTTCTTGGATATCGCAATTATGCTGACGATGTGGTCAGATCCTT
TATTCAAAAATCCATTGAAAATGGGATTGATATTGTCCGTATTTTCGATGCTTTAAACGACCCACGCAACTTGCAAACAG
CTGTTTCAGCGACTAAAAAATTTGGAGGGCATGCTCAAGTTGCCATTTCTTACACGACAAGTCCGGTACATACCATTGAC
TACTTTGTTGAATTGGCGAAAGCTTACCAAGCTATCGGAGCGGACTCCATTTGTATCAAAGACATGGCTGGTGTCTTAAC
TCCTGAAATAGGTTACCAATTGGTCAAATGTATCAAGGAGAATACAACTATCCCTCTTGAGGTTCATACCCATGCTACCA
GTGGTATTTCAGAAATGACTTACTTAAAAGTAGCAGAAGCAGGAGCTGATATTATTGATACGGCGATTTCCTCTTTTTCA
GGTGGAACCAGTCAGCCTGCCACAGAGTCAATGGCGATTGCCTTGACGGATTTAGGCTTTGACACTGGCTTGGATATGCA
AGAGGTGGCCAAAGTTGCAGAATATTTCAACACTATTCGTGACCACTATCGAGAAGTAGGGATTTTAAATCCTAAAGTCA
AAGATACTGAGCCAAAAACATTGATTTACCAAGTTCCAGGTGGCATGCTATCAAACCTATTGAGCCAATTAGCCGAGCAA
GGCCTAGCTGATAAATACGAAGAAGTCTTAGCAGAAGTACCTAAAGTAAGGGCTGATCTTGGGTATCCGCCACTCGTAAC
GCCATTATCACAAATGGTTGGCACACAGGCCTTGATGAATATCATCTCAGGGGAACGCTACAAGGTAGTTCCAAATGAAA
TTAAAGACTATGTTCGAGGGCTATACGGTCAATCACCAGCGCCATTAGTAGAAGGTATCAAAGAGAAAATCATTGGTGAC
GAAGCAGTCATTGCTTGCAGACCAGCTGACTTAATCGAGCCTCAAATGATTTATCTACGTGACGAGATTGCTCAATACGC
TCGTTCAGAAGAAGACGTGTTAAGCTATGCGAGTTTCCCACAGCAAGCCAGAGATTTCTTGGGACGCCGTGAAGATCCTT
TCTATGATGTTCCGGTTCAAGAAGTTACTGTACAACTGGACATTCAAGACTAA

Upstream 100 bases:

>100_bases
TACGTAAGCACAGTGTCGAGGAGATGCAGACTGCTATTTCAAAATTACTCCATTCATTTTTCAATAAAGACAACCAATCA
TCGTCATCAGATAAGACAGG

Downstream 100 bases:

>100_bases
CAGGGAATGACTAATCCTCTTAACCATTAATCTCCTTGGTGAAACGCATTTGCTGTAAGAATAATACCAAAAACCTACCT
GATTTTGATAATCAGATAGG

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase B [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MMRRTIMTKIRITETVLRDGQQSQIATRMTTKEMIPILETLDNAGYHALEMWGGATFDSCLRFLNEDPWERLRAIRKAVK
KTKLQMLLRGQNLLGYRNYADDVVRSFIQKSIENGIDIVRIFDALNDPRNLQTAVSATKKFGGHAQVAISYTTSPVHTID
YFVELAKAYQAIGADSICIKDMAGVLTPEIGYQLVKCIKENTTIPLEVHTHATSGISEMTYLKVAEAGADIIDTAISSFS
GGTSQPATESMAIALTDLGFDTGLDMQEVAKVAEYFNTIRDHYREVGILNPKVKDTEPKTLIYQVPGGMLSNLLSQLAEQ
GLADKYEEVLAEVPKVRADLGYPPLVTPLSQMVGTQALMNIISGERYKVVPNEIKDYVRGLYGQSPAPLVEGIKEKIIGD
EAVIACRPADLIEPQMIYLRDEIAQYARSEEDVLSYASFPQQARDFLGRREDPFYDVPVQEVTVQLDIQD

Sequences:

>Translated_470_residues
MMRRTIMTKIRITETVLRDGQQSQIATRMTTKEMIPILETLDNAGYHALEMWGGATFDSCLRFLNEDPWERLRAIRKAVK
KTKLQMLLRGQNLLGYRNYADDVVRSFIQKSIENGIDIVRIFDALNDPRNLQTAVSATKKFGGHAQVAISYTTSPVHTID
YFVELAKAYQAIGADSICIKDMAGVLTPEIGYQLVKCIKENTTIPLEVHTHATSGISEMTYLKVAEAGADIIDTAISSFS
GGTSQPATESMAIALTDLGFDTGLDMQEVAKVAEYFNTIRDHYREVGILNPKVKDTEPKTLIYQVPGGMLSNLLSQLAEQ
GLADKYEEVLAEVPKVRADLGYPPLVTPLSQMVGTQALMNIISGERYKVVPNEIKDYVRGLYGQSPAPLVEGIKEKIIGD
EAVIACRPADLIEPQMIYLRDEIAQYARSEEDVLSYASFPQQARDFLGRREDPFYDVPVQEVTVQLDIQD
>Mature_470_residues
MMRRTIMTKIRITETVLRDGQQSQIATRMTTKEMIPILETLDNAGYHALEMWGGATFDSCLRFLNEDPWERLRAIRKAVK
KTKLQMLLRGQNLLGYRNYADDVVRSFIQKSIENGIDIVRIFDALNDPRNLQTAVSATKKFGGHAQVAISYTTSPVHTID
YFVELAKAYQAIGADSICIKDMAGVLTPEIGYQLVKCIKENTTIPLEVHTHATSGISEMTYLKVAEAGADIIDTAISSFS
GGTSQPATESMAIALTDLGFDTGLDMQEVAKVAEYFNTIRDHYREVGILNPKVKDTEPKTLIYQVPGGMLSNLLSQLAEQ
GLADKYEEVLAEVPKVRADLGYPPLVTPLSQMVGTQALMNIISGERYKVVPNEIKDYVRGLYGQSPAPLVEGIKEKIIGD
EAVIACRPADLIEPQMIYLRDEIAQYARSEEDVLSYASFPQQARDFLGRREDPFYDVPVQEVTVQLDIQD

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=32.5942350332594, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=32.5942350332594, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=32.5942350332594, Blast_Score=228, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17562816, Length=483, Percent_Identity=33.7474120082816, Blast_Score=255, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6321376, Length=461, Percent_Identity=32.9718004338395, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319695, Length=461, Percent_Identity=32.7548806941432, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI281363050, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24652224, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24652222, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24652220, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24652218, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24652212, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24652210, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24652214, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI19921944, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24652216, Length=461, Percent_Identity=34.70715835141, Blast_Score=251, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 52374; Mature: 52374

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRTIMTKIRITETVLRDGQQSQIATRMTTKEMIPILETLDNAGYHALEMWGGATFDSC
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHH
LRFLNEDPWERLRAIRKAVKKTKLQMLLRGQNLLGYRNYADDVVRSFIQKSIENGIDIVR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
IFDALNDPRNLQTAVSATKKFGGHAQVAISYTTSPVHTIDYFVELAKAYQAIGADSICIK
HHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHH
DMAGVLTPEIGYQLVKCIKENTTIPLEVHTHATSGISEMTYLKVAEAGADIIDTAISSFS
HHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHCC
GGTSQPATESMAIALTDLGFDTGLDMQEVAKVAEYFNTIRDHYREVGILNPKVKDTEPKT
CCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
LIYQVPGGMLSNLLSQLAEQGLADKYEEVLAEVPKVRADLGYPPLVTPLSQMVGTQALMN
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IISGERYKVVPNEIKDYVRGLYGQSPAPLVEGIKEKIIGDEAVIACRPADLIEPQMIYLR
HHCCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCHHHCCCHHHHHH
DEIAQYARSEEDVLSYASFPQQARDFLGRREDPFYDVPVQEVTVQLDIQD
HHHHHHHCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHEEEEEEECC
>Mature Secondary Structure
MMRRTIMTKIRITETVLRDGQQSQIATRMTTKEMIPILETLDNAGYHALEMWGGATFDSC
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHH
LRFLNEDPWERLRAIRKAVKKTKLQMLLRGQNLLGYRNYADDVVRSFIQKSIENGIDIVR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
IFDALNDPRNLQTAVSATKKFGGHAQVAISYTTSPVHTIDYFVELAKAYQAIGADSICIK
HHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHH
DMAGVLTPEIGYQLVKCIKENTTIPLEVHTHATSGISEMTYLKVAEAGADIIDTAISSFS
HHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHCC
GGTSQPATESMAIALTDLGFDTGLDMQEVAKVAEYFNTIRDHYREVGILNPKVKDTEPKT
CCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
LIYQVPGGMLSNLLSQLAEQGLADKYEEVLAEVPKVRADLGYPPLVTPLSQMVGTQALMN
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IISGERYKVVPNEIKDYVRGLYGQSPAPLVEGIKEKIIGDEAVIACRPADLIEPQMIYLR
HHCCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCHHHCCCHHHHHH
DEIAQYARSEEDVLSYASFPQQARDFLGRREDPFYDVPVQEVTVQLDIQD
HHHHHHHCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 11195096 [H]