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The map label for this gene is ddh [H]

Identifier: 94994435

GI number: 94994435

Start: 984770

End: 985765

Strand: Direct

Name: ddh [H]

Synonym: MGAS10750_Spy1039

Alternate gene names: 94994435

Gene position: 984770-985765 (Clockwise)

Preceding gene: 94994434

Following gene: 94994436

Centisome position: 50.84

GC content: 38.96

Gene sequence:

>996_bases
TTGATGAAATTAAAATTATATAATGTTAGAGGCGAAGAAGCAGTCTTAGCAAAAAAATGGGCTGATGACAATGGGATTGA
GATTTCCTTGACAGAGTCTTCCTTAACTCCTGAAACGGTTAAAGAAGCTGAAGGCTTTGACGGGATTGCCAATGCCCAAA
TTGGTCCTTTAGATGATGCGATTTATCCTCTCTTAAAGGAAATGGGGATTAAACAAATCGCTCAGCGCAGTGCTGGTGTC
GATATGTATAACCTTGATTTGGCCACCGAAAATGACATTATTATCACAAATGTTCCTAGCTATTCTCCAGAATCCATTGC
AGAATTTACGGTTACTATTGCCCTTAATTTAATTCGTCATGTGGAGTTGATTCGTGAAAATGTTAAAAAACAAAATTTCA
CTTGGGGACTCCCTATCCGCGGCCGTGTTTTAGGTGATATGACAGTTGCGATTATCGGAACTGGACGTATTGGTCTAGCT
ACTGCTAAAATCTTTAAAGGTTTTGGCTTCAAGGTCGTTGGATATGATATTTACCAAAGCGATGCTGCCAAAGCTGTCTT
GGACTATAAGGAATCTGTAGAAGAAGCGATTAAAGATGCTGATCTTGTTTCCTTACACATGCCACCAACTGCAGAGAACA
CACACCTTTTCAATGCTGATTTATTTAAATCATTCAAAAAAGGGGCTATTTTGATGAATATGGCGCGTGGTGCTCTCATT
GAGACGCAAGATTTACTGGATGCTTTGGATGCAGGCTTACTGAGCGGAGCTGGTATTGACACTTACGAATTTGAAGGACC
TTATATACCTAAGAATTTTGAAGGTCAAGAAATTACAGATTCACTATTTAAAGCTTTGATTAACCATCCTAAGGTTATTT
ATACGCCTCATGCAGCTTATTATACTGATGAAGCCGTTAAAAACCTAGTTGAAGGTGCCCTTAATGCTACAGTAGAGATT
ATCAAAACTGGGACAACGACAACTCGTGTTAACTAA

Upstream 100 bases:

>100_bases
CACCAATTGTTCTCAATATAATCTTTAACCACCTTTTTATCAAGGTGCTTAAAGTGATTGATCCAATGGATTACAAACTT
GATATCTAAGAAAGGAACTT

Downstream 100 bases:

>100_bases
CAACTGATTTGACGTCCATTATAAAGGAATAATTTCAAAAATTCCTTTATAATGGACTTTTTTGCATTAGTCCGTTATAA
TAGACTGTAAGAAAGGGGAC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MMKLKLYNVRGEEAVLAKKWADDNGIEISLTESSLTPETVKEAEGFDGIANAQIGPLDDAIYPLLKEMGIKQIAQRSAGV
DMYNLDLATENDIIITNVPSYSPESIAEFTVTIALNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLA
TAKIFKGFGFKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNADLFKSFKKGAILMNMARGALI
ETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEI
IKTGTTTTRVN

Sequences:

>Translated_331_residues
MMKLKLYNVRGEEAVLAKKWADDNGIEISLTESSLTPETVKEAEGFDGIANAQIGPLDDAIYPLLKEMGIKQIAQRSAGV
DMYNLDLATENDIIITNVPSYSPESIAEFTVTIALNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLA
TAKIFKGFGFKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNADLFKSFKKGAILMNMARGALI
ETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEI
IKTGTTTTRVN
>Mature_331_residues
MMKLKLYNVRGEEAVLAKKWADDNGIEISLTESSLTPETVKEAEGFDGIANAQIGPLDDAIYPLLKEMGIKQIAQRSAGV
DMYNLDLATENDIIITNVPSYSPESIAEFTVTIALNLIRHVELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLA
TAKIFKGFGFKVVGYDIYQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNADLFKSFKKGAILMNMARGALI
ETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAYYTDEAVKNLVEGALNATVEI
IKTGTTTTRVN

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=32.319391634981, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=32.8301886792453, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=31.5589353612167, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=31.5589353612167, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=31.5589353612167, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=29.1044776119403, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI6912396, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1787645, Length=318, Percent_Identity=31.7610062893082, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87082289, Length=306, Percent_Identity=27.1241830065359, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789279, Length=259, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=263, Percent_Identity=25.4752851711027, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=32.2314049586777, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=27.2373540856031, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=262, Percent_Identity=29.0076335877863, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=263, Percent_Identity=27.3764258555133, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=262, Percent_Identity=28.2442748091603, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=209, Percent_Identity=28.2296650717703, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=208, Percent_Identity=24.5192307692308, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=33.5907335907336, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=33.5907335907336, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=33.5907335907336, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=33.5907335907336, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=33.5907335907336, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19921140, Length=288, Percent_Identity=30.5555555555556, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585516, Length=332, Percent_Identity=24.6987951807229, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=27.2357723577236, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45552429, Length=247, Percent_Identity=28.3400809716599, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 36251; Mature: 36251

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLKLYNVRGEEAVLAKKWADDNGIEISLTESSLTPETVKEAEGFDGIANAQIGPLDDA
CEEEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHH
IYPLLKEMGIKQIAQRSAGVDMYNLDLATENDIIITNVPSYSPESIAEFTVTIALNLIRH
HHHHHHHHCHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
VELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLATAKIFKGFGFKVVGYDIYQS
HHHHHHHHHHCCCEECCCCCCEEECCEEEEEEECCCHHHHHHHHHHCCCEEEEEEEHHHH
DAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNADLFKSFKKGAILMNMARGALI
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECHHHHHHHHCCEEEEEHHCCCEE
ETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAY
CHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHH
YTDEAVKNLVEGALNATVEIIKTGTTTTRVN
HHHHHHHHHHHHHHHCEEEEEECCCEEECCC
>Mature Secondary Structure
MMKLKLYNVRGEEAVLAKKWADDNGIEISLTESSLTPETVKEAEGFDGIANAQIGPLDDA
CEEEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHH
IYPLLKEMGIKQIAQRSAGVDMYNLDLATENDIIITNVPSYSPESIAEFTVTIALNLIRH
HHHHHHHHCHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
VELIRENVKKQNFTWGLPIRGRVLGDMTVAIIGTGRIGLATAKIFKGFGFKVVGYDIYQS
HHHHHHHHHHCCCEECCCCCCEEECCEEEEEEECCCHHHHHHHHHHCCCEEEEEEEHHHH
DAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNADLFKSFKKGAILMNMARGALI
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECHHHHHHHHCCEEEEEHHCCCEE
ETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPHAAY
CHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHH
YTDEAVKNLVEGALNATVEIIKTGTTTTRVN
HHHHHHHHHHHHHHHCEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]