Click here to switch to the map view.

The map label for this gene is nox [C]

Identifier: 94994417

GI number: 94994417

Start: 968567

End: 969937

Strand: Direct

Name: nox [C]

Synonym: MGAS10750_Spy1021

Alternate gene names: 94994417

Gene position: 968567-969937 (Clockwise)

Preceding gene: 94994416

Following gene: 94994419

Centisome position: 50.0

GC content: 40.34

Gene sequence:

>1371_bases
ATGAGTAAAATCGTTGTTGTTGGTGCAAACCATGCTGGTACGGCCTGTATCAAGACTATGTTAACAAACTACGGTGATGC
TAATGAGATTGTTGTATTTGACCAAAACTCAAATATTTCATTTTTAGGCTGTGGTATGGCACTTTGGATTGGTGAGCAAA
TTGCTGGACCAGAAGGACTTTTCTATTCAGATAAAGAAGAATTAGAGTCCTTAGGGGCTAAAGTTTACATGGAATCACCT
GTTCAATCAATCGACTACGATGCCAAAACAGTGACAGCGCTTGTTGATGGTAAAAACCACGTGGAAACTTACGACAAGTT
GATTTTTGCAACTGGCTCACAACCTATCTTACCACCGATTAAAGGTGCCGAAATCAAAGAAGGATCACTTGAATTTGAAG
CAACTCTTGAAAATCTTCAATTTGTGAAGTTATACCAAAACTCAGCTGATGTGATTGCAAAGCTTGAAAACAAAGACATT
AAACGTGTAGCCGTAGTTGGTGCTGGTTACATTGGTGTTGAGTTAGCTGAAGCTTTCCAACGTAAAGGTAAAGAAGTGGT
TCTGATTGATGTCGTGGACACTTGCTTGGCAGGTTATTACGACCGTGATTTGACTGACTTAATGGCTAAAAACATGGAAG
AACATGGTATTCAACTAGCCTTTGGTGAAACAGTTAAAGAAGTAGCTGGTAATGGTAAGGTTGAAAAGATCATTACTGAC
AAAAATGAGTACGATGTGGATATGGTTATCCTCGCCGTTGGTTTCCGTCCAAACACAACTCTTGGAAATGGTAAGATTGA
GCTTTTCCGTAATGGTGCTTTCCTTGTCAATAAACGCCAAGAAACTTCTATTCCAGGTGTTTATGCTATCGGTGACTGTG
CAACTATCTACGATAATGCTACTCGCGATACAAACTACATTGCTTTAGCTTCAAATGCCGTCCGTACAGGAATTGTAGCA
GCACATAACGCTTGTGGTACAGACCTTGAAGGAATCGGTGTCCAAGGCTCAAACGGTATTTCCATTTACGGCTTGCACAT
GGTATCAACTGGTTTGACACTTGAAAAAGCAAAACGACTTGGTTTTGATGCTGCAGTGACTGAGTATACTGATAACCAAA
AACCTGAATTTATCGAACACGGTAACTTCCCAGTAACCATTAAGATTGTTTACGATAAAGACTCACGTCGTATCTTGGGT
GCTCAAATGGCAGCCCGTGAAGATGTGTCAATGGGAATTCACATGTTCTCACTTGCTATCCAAGAAGGCGTAACCATTGA
AAAGTTGGCATTAACTGATATTTTCTTCTTACCACATTTCAACAAACCTTACAACTACATCACAATGGCAGCACTTGGTG
CCAAAGACTAG

Upstream 100 bases:

>100_bases
GAAAAAATAACTCAAAAAAGTGAGCAATATATTTGGAAGCGTTTTTTGACTGTGGTATAATAGAGCCCTATATAATATTG
TGAAATGAGGAACAAAATAT

Downstream 100 bases:

>100_bases
TATCTGATAGGAAAAAGCCAGAGCAGTTCAGCAGCACTGGCTTTTTTGCTTTTTAATTGTTGCAACCTGAAAAGTTCTAA
ACTTATGATTATCCTCTTAT

Product: NADH oxidase H2O-forming

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGCGMALWIGEQIAGPEGLFYSDKEELESLGAKVYMESP
VQSIDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDI
KRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITD
KNEYDVDMVILAVGFRPNTTLGNGKIELFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVA
AHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILG
AQMAAREDVSMGIHMFSLAIQEGVTIEKLALTDIFFLPHFNKPYNYITMAALGAKD

Sequences:

>Translated_456_residues
MSKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGCGMALWIGEQIAGPEGLFYSDKEELESLGAKVYMESP
VQSIDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDI
KRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITD
KNEYDVDMVILAVGFRPNTTLGNGKIELFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVA
AHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILG
AQMAAREDVSMGIHMFSLAIQEGVTIEKLALTDIFFLPHFNKPYNYITMAALGAKD
>Mature_455_residues
SKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGCGMALWIGEQIAGPEGLFYSDKEELESLGAKVYMESPV
QSIDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDIK
RVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITDK
NEYDVDMVILAVGFRPNTTLGNGKIELFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVAA
HNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILGA
QMAAREDVSMGIHMFSLAIQEGVTIEKLALTDIFFLPHFNKPYNYITMAALGAKD

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=334, Percent_Identity=25.748502994012, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI21389617, Length=334, Percent_Identity=25.748502994012, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI65787454, Length=334, Percent_Identity=25.748502994012, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789065, Length=230, Percent_Identity=30, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789765, Length=352, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639257, Length=274, Percent_Identity=24.8175182481752, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281359715, Length=274, Percent_Identity=24.8175182481752, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281359713, Length=274, Percent_Identity=24.8175182481752, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639250, Length=274, Percent_Identity=24.8175182481752, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI18543267, Length=274, Percent_Identity=24.8175182481752, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639252, Length=274, Percent_Identity=24.8175182481752, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358499, Length=207, Percent_Identity=29.4685990338164, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49618; Mature: 49487

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGCGMALWIGEQIAGPEGL
CCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCEEEECHHCCCCCCC
FYSDKEELESLGAKVYMESPVQSIDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPI
EECCHHHHHHCCCEEEECCCHHHCCCCCEEEEEEECCCCHHHHHHEEEEECCCCCCCCCC
KGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDIKRVAVVGAGYIGVELAEAFQ
CCCCCCCCCEEEEEHHCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHH
RKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITD
HCCCEEEEEEEHHHHHHCCCCCCHHHHHHCCHHHCCEEEEEHHHHHHHHCCCCEEEEEEC
KNEYDVDMVILAVGFRPNTTLGNGKIELFRNGAFLVNKRQETSIPGVYAIGDCATIYDNA
CCCCCEEEEEEEECCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCEEEECCCCEECCCC
TRDTNYIALASNAVRTGIVAAHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRL
CCCCCEEEEECCCHHHCEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHC
GFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAI
CCCCEEEECCCCCCCCHHHCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHEEHHH
QEGVTIEKLALTDIFFLPHFNKPYNYITMAALGAKD
HCCCEEEEEEEEEEEECCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGCGMALWIGEQIAGPEGL
CEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCEEEECHHCCCCCCC
FYSDKEELESLGAKVYMESPVQSIDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPI
EECCHHHHHHCCCEEEECCCHHHCCCCCEEEEEEECCCCHHHHHHEEEEECCCCCCCCCC
KGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDIKRVAVVGAGYIGVELAEAFQ
CCCCCCCCCEEEEEHHCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHH
RKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITD
HCCCEEEEEEEHHHHHHCCCCCCHHHHHHCCHHHCCEEEEEHHHHHHHHCCCCEEEEEEC
KNEYDVDMVILAVGFRPNTTLGNGKIELFRNGAFLVNKRQETSIPGVYAIGDCATIYDNA
CCCCCEEEEEEEECCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCEEEECCCCEECCCC
TRDTNYIALASNAVRTGIVAAHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRL
CCCCCEEEEECCCHHHCEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHC
GFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAI
CCCCEEEECCCCCCCCHHHCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHEEHHH
QEGVTIEKLALTDIFFLPHFNKPYNYITMAALGAKD
HCCCEEEEEEEEEEEECCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA