Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 94994412

GI number: 94994412

Start: 962022

End: 963284

Strand: Direct

Name: glyA [H]

Synonym: MGAS10750_Spy1016

Alternate gene names: 94994412

Gene position: 962022-963284 (Clockwise)

Preceding gene: 94994411

Following gene: 94994413

Centisome position: 49.66

GC content: 42.6

Gene sequence:

>1263_bases
ATGACAATGATTTTTGATAAAGGTAATGTTGAAGACTTTGATAAAGAGCTTTGGGATGCCATTCATGCTGAAGAAGAAAG
ACAAGAACATCATATCGAATTGATTGCATCTGAAAACATGGTTTCAAAAGCTGTCATGGCAGCTCAAGGTTCTGTTTTAA
CCAATAAGTATGCAGAAAGCTATCCAGGTAATCGCTATTATGGTGGAACAGAATGTGTGGATATTGTCGAAACGCTTGCT
ATTGAACGTGCTAAGAAACTTTTCGGTGCCGCATTTGCCAATGTTCAAGCCCATTCCGGAAGTCAAGCCAATGCAGCAGC
TTATATGGCCTTGATTGAGGCTGGTGACACCGTATTAGGAATGGATTTGGCTGCAGGTGGTCATCTCACGCATGGCTCTC
CAGTAAATTTTTCTGGAAAAACCTACCATTTTGTGGGTTACTCAGTAGATGCTGATACTGAAACGTTAAATTATGAGGCG
ATTTTAGAACAAGCAAAGGCGGTCCAGCCAAAGCTTATCGTTGCAGGGGCTTCGGCCTACTCTAGAAGCATTGATTTTGA
AAAGTTTCGTGCCATTGCTGATCACGTAGGTGCTTACTTAATGGTGGACATGGCTCACATCGCTGGCCTTGTAGCAGCAG
GTGTGCACCCGAGTCCTGTCCCTTATGCGCATATTGTGACATCAACAACCCATAAAACCTTACGTGGTCCTCGTGGAGGC
TTGATATTAACCAATGACGAAGCTCTTGCTAAAAAGATTAATTCGGCCGTTTTCCCTGGTTTACAAGGAGGACCTCTGGA
ACACGTGATTGCTGCCAAAGCGGTTGCCTTCAAAGAAGCCTTGGATCCAGCCTTTAAAGACTATGCACAAGCTATTATTG
ATAATACTGCGGCTATGGCAGCAGTTTTTGCACAAGATGATCGTTTCCGTCTGATCTCAGGTGGTACAGATAATCATGTC
TTTTTAGTAGATGTCACTAAGGTTATTGCTAATGGTAAACTAGCGCAAAATCTTCTGGATGAGGTTAATATTACCCTTAA
TAAAAATGCCATTCCTTTTGAAACCTTGTCGCCATTTAAAACCTCAGGTATTCGCATTGGTTGTGCTGCCATAACCAGCC
GTGGTATGAGTGTTAAAGAGAGTCAGACCATTGCCCGTCTTATCATCAAAGCCTTGGTTAATCATGATCAAGAAACTATT
CTTGAAGAAGTCCGTCAGGAAGTGCGTCAGTTAACCGATGCTTTCCCACTCTATAAAAAGTAA

Upstream 100 bases:

>100_bases
AATTCTGCCAGTCATCGTAAAGAAGCACATGCTTTTTACCGAAACCTCGACTATGCAGATGATAAAACACAATTACGATT
CATCAAAAACTTACAAGGAG

Downstream 100 bases:

>100_bases
GGAATCATGTTAGATAGTTATATAAAACGTATTGTCATTCATCAATTTTCTCCCAATGACACTGAGTTACTGTTATCAGA
TCGTTTAGTGAGCATTACAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAESYPGNRYYGGTECVDIVETLA
IERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEA
ILEQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGG
LILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHV
FLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMSVKESQTIARLIIKALVNHDQETI
LEEVRQEVRQLTDAFPLYKK

Sequences:

>Translated_420_residues
MTMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAESYPGNRYYGGTECVDIVETLA
IERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEA
ILEQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGG
LILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHV
FLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMSVKESQTIARLIIKALVNHDQETI
LEEVRQEVRQLTDAFPLYKK
>Mature_419_residues
TMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAESYPGNRYYGGTECVDIVETLAI
ERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEAI
LEQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGL
ILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVF
LVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMSVKESQTIARLIIKALVNHDQETIL
EEVRQEVRQLTDAFPLYKK

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=41.6299559471366, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=41.6299559471366, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=41.6299559471366, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=41.6299559471366, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=42.6991150442478, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI22547186, Length=457, Percent_Identity=41.1378555798687, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI22547189, Length=440, Percent_Identity=38.1818181818182, Blast_Score=275, Evalue=7e-74,
Organism=Escherichia coli, GI1788902, Length=418, Percent_Identity=58.133971291866, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI25144732, Length=402, Percent_Identity=44.5273631840796, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25144729, Length=402, Percent_Identity=44.5273631840796, Blast_Score=329, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6319739, Length=406, Percent_Identity=45.0738916256158, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323087, Length=440, Percent_Identity=41.5909090909091, Blast_Score=312, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24640005, Length=449, Percent_Identity=41.2026726057906, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI221329721, Length=449, Percent_Identity=41.2026726057906, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45329; Mature: 45198

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAES
CEEEECCCCCCHHHHHHHHHHCCHHHHHHHHEEEEECCHHHHHHHHHHCCCHHHHHHHHC
YPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEE
MDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEAILEQAKAVQPKLIVAGASAY
EEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECHHH
SRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCC
LILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMA
EEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHH
AVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFK
HHHCCCCCEEEEECCCCCEEEEEEHHHHHHCCHHHHHHHHHCCEEECCCCCCCCCCCCCC
TSGIRIGCAAITSRGMSVKESQTIARLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
CCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAES
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHEEEEECCHHHHHHHHHHCCCHHHHHHHHC
YPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEE
MDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTETLNYEAILEQAKAVQPKLIVAGASAY
EEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECHHH
SRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHCCCCCC
LILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMA
EEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHH
AVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFK
HHHCCCCCEEEEECCCCCEEEEEEHHHHHHCCHHHHHHHHHCCEEECCCCCCCCCCCCCC
TSGIRIGCAAITSRGMSVKESQTIARLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
CCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA