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The map label for this gene is ppnK [H]

Identifier: 94994395

GI number: 94994395

Start: 946490

End: 947329

Strand: Direct

Name: ppnK [H]

Synonym: MGAS10750_Spy0999

Alternate gene names: 94994395

Gene position: 946490-947329 (Clockwise)

Preceding gene: 94994394

Following gene: 94994396

Centisome position: 48.86

GC content: 37.38

Gene sequence:

>840_bases
GTGATGACACAGATGAATTATACAGGTAAGGTAAAGCGAGTTGCTATTATTGCAAATGGTAAGTACCAAAGTAAACGCGT
TGCCTCCAAACTTTTCTCCGTATTTAAAGATGATCCTGATTTCTATCTTTCAAAGAAAAATCCGGATATTGTGATTTCTA
TTGGCGGAGATGGGATGCTCTTATCTGCTTTTCACATGTATGAAAAAGAATTAGATAAGGTACGTTTTGTAGGAATCCAC
ACCGGTCATCTTGGCTTTTATACCGATTATAGGGATTTTGAAGTTGATAAATTGATTGATAATTTAAGAAAAGACAAGGG
AGAACAAATCTCTTATCCTATTTTAAAAGTTGCTATTACTTTAGATGATGGTCGTGTGGTTAAAGCGCGTGCTTTGAATG
AAGCGACGGTTAAGCGTATTGAAAAAACGATGGTAGCAGATGTTATTATTAACCATGTCAAATTTGAAAGCTTCCGAGGT
GATGGGATTTCAGTATCGACCCCGACAGGGAGCACAGCCTACAATAAATCTTTAGGTGGTGCTGTCTTGCATCCGACGAT
TGAAGCGCTGCAATTGACGGAAATTTCCAGTCTTAATAACCGTGTCTTTAGAACCTTGGGCTCATCAATCATTATTCCCA
AAAAAGATAAGATTGAGTTAGTGCCAAAACGATTAGGAATTTATACCATTTCCATTGATAATAAAACCTATCAGTTAAAA
AATGTGACGAAGGTGGAGTATTTTATCGACGATGAGAAAATTCATTTTGTTTCCTCTCCGAGTCATACGAGCTTTTGGGA
AAGGGTCAAGGATGCCTTTATTGGAGAGATTGACTCATGA

Upstream 100 bases:

>100_bases
GAATTAGACGAAGAAATGCGTAAGATTCGAGAAGATATTCGGGAGGCTCAATTATTGTTTGACCCCGTGACACGAAATTT
AAGTGATGGTGTAGGAAATA

Downstream 100 bases:

>100_bases
GATTTGAATTTGTAGCAGATAAACGAATAAAAGTAAAAACCCTTTTAAAAAGTCATGATGTCTCTAAAGGACTATTGGCT
AAAATCAAATATAAGGGCGG

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGMLLSAFHMYEKELDKVRFVGIH
TGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAITLDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRG
DGISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLK
NVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEIDS

Sequences:

>Translated_279_residues
MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGMLLSAFHMYEKELDKVRFVGIH
TGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAITLDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRG
DGISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLK
NVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEIDS
>Mature_279_residues
MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGMLLSAFHMYEKELDKVRFVGIH
TGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAITLDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRG
DGISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLK
NVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEIDS

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788968, Length=152, Percent_Identity=32.2368421052632, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320794, Length=190, Percent_Identity=30.5263157894737, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 31508; Mature: 31508

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGML
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCHH
LSAFHMYEKELDKVRFVGIHTGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAIT
HHHHHHHHHHHCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEE
LDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRGDGISVSTPTGSTAYNKSLGG
ECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCCCCCC
AVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLK
EEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCEEEEEECCCEEEEC
NVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEIDS
CCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMTQMNYTGKVKRVAIIANGKYQSKRVASKLFSVFKDDPDFYLSKKNPDIVISIGGDGML
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCHH
LSAFHMYEKELDKVRFVGIHTGHLGFYTDYRDFEVDKLIDNLRKDKGEQISYPILKVAIT
HHHHHHHHHHHCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEE
LDDGRVVKARALNEATVKRIEKTMVADVIINHVKFESFRGDGISVSTPTGSTAYNKSLGG
ECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCCCCCC
AVLHPTIEALQLTEISSLNNRVFRTLGSSIIIPKKDKIELVPKRLGIYTISIDNKTYQLK
EEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCEEEEEECCCEEEEC
NVTKVEYFIDDEKIHFVSSPSHTSFWERVKDAFIGEIDS
CCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA