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The map label for this gene is dacA1 [H]

Identifier: 94994364

GI number: 94994364

Start: 918263

End: 919618

Strand: Direct

Name: dacA1 [H]

Synonym: MGAS10750_Spy0968

Alternate gene names: 94994364

Gene position: 918263-919618 (Clockwise)

Preceding gene: 94994363

Following gene: 94994366

Centisome position: 47.4

GC content: 39.23

Gene sequence:

>1356_bases
GTGTTATTGTCACAGGGTACTTGCTTTATGAGCTTGTTTAAGCTACTAAAGGTGTGTGCCACTATACTTCCTTCCAAATT
TCTGAGAATTTTTGTTATAATAGTAACTATGAAAGATATAATGATAAAAAGGTGGGTTATCCTTTTTTTTATGGTATTAA
CTTGTTCAGGGTTTGGTAAAACAGTTCTCGCAGCTGATTTTCAAGTGGGAGCAGAACATGCGATTGTCGTAGAGGCAGAC
TCTGGGAGAGTTCTGTATGAGAAAGACGCTAAGACGCCAGATGCTATTGCCTCTTTGACCAAATTGGTGACGGCTTATCT
GGTTTTAGATAAGGTTAAATCAGGCCAGCTGCAATTATCAGATCAAGTTAATCTCTCAGATTATGCCTTTGAGTTAACAA
AAGATAGGTCTTTAAGTAATGTACCTTTTGACAAAAAAACTTATTCAGTTCAAGACCTGTTGACAGCTACTTTGGTAGCA
AGCTCAAATAGCGCTGCTATTGCGTTAGCCGAAAAAGTGGCGGGTTCAGAGCTTCATTTTGTAAATCAAATGAGAGAACA
GCTATCTCATTGGGGGATTACTTCTGGTAAAATCCTCAACGCCTCAGGTCTGCCAAATGAGGTGTTAAAGGATAATCGTT
ATCCTGGTTCTGCGTTGGAAGAAGAAAATACCTTGAGTGCTCAAGATGTTGCAGTTGTGACGATGCATTTGTTAGAAGAT
TTTCCTGAGATTTTAGAGATCACCAAACAAACAGAAGTTAATTTTGCTGGCAATTCTATTAAAAGTTTTAATCAACTCTT
ACCAGGTATGGCTAAGGGTAGAGCAGGAGTGGATGGTTTAAAGACTGGGACAACAGACTTGGCAGGTCATTGTCTTGTGG
TAACTTCTATTGAAAATGGTATGCGAGTGATTACCGTTATTCTAAATGCCGATGGATCTGATAAAAACCAAAACACGCGG
TTTGAGCAAGCAAATCGTTTGTTGGACTATGTGGCTAGAACTTATTGTCGTCGTAAGATTCTTAAAAAAGGAAGTCTTGT
CTCGGAGCGGTCGCTCCCTATTCAAGATGGCCAAGTAAAAGAACTACCGGTATCTGTTGCCGAAGATGTAACCATCATTT
TGCAACAGGGTGAACAAGTTCCCAAACCTAAACAATTTATGATATCAGAGACTTCTTTACTAGCACCGATTACTAAAGGT
GAAGTGGTTGCTTATTTGACGTCTCCAAGAATAACAGATCAGTCAGTGAGGTATTTAAAGGAACCTAAGCGTATTCCTCT
TAAAGCTAGCCAATCTCTTAAAAAAGCCTCTGACTTACAGCTGTGGTGGCGAGATTTTCTTGAAAAAAGACGTTAA

Upstream 100 bases:

>100_bases
AATGTAATAAGTTCAGGATTAGATTCCATTTTATACCAAAATTCCTGCCAAACAACTAATTGATATAACGAAGCTTATTA
TATCGCCCATATAACAGGAT

Downstream 100 bases:

>100_bases
AGATAAGAATAAAATAATTTTAAAACAATCAAAAAAAGACAGTTATGAAAGAATTTTTTCATAACTGTCTTTTTAGTTTA
CAGTGAGTATGATTTGGAAT

Product: D-alanyl-D-alanine serine-type carboxypeptidase

Products: NA

Alternate protein names: CPase; DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 5; PBP-5 [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLLSQGTCFMSLFKLLKVCATILPSKFLRIFVIIVTMKDIMIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEAD
SGRVLYEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFDKKTYSVQDLLTATLVA
SSNSAAIALAEKVAGSELHFVNQMREQLSHWGITSGKILNASGLPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLED
FPEILEITKQTEVNFAGNSIKSFNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTR
FEQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVKELPVSVAEDVTIILQQGEQVPKPKQFMISETSLLAPITKG
EVVAYLTSPRITDQSVRYLKEPKRIPLKASQSLKKASDLQLWWRDFLEKRR

Sequences:

>Translated_451_residues
MLLSQGTCFMSLFKLLKVCATILPSKFLRIFVIIVTMKDIMIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEAD
SGRVLYEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFDKKTYSVQDLLTATLVA
SSNSAAIALAEKVAGSELHFVNQMREQLSHWGITSGKILNASGLPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLED
FPEILEITKQTEVNFAGNSIKSFNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTR
FEQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVKELPVSVAEDVTIILQQGEQVPKPKQFMISETSLLAPITKG
EVVAYLTSPRITDQSVRYLKEPKRIPLKASQSLKKASDLQLWWRDFLEKRR
>Mature_451_residues
MLLSQGTCFMSLFKLLKVCATILPSKFLRIFVIIVTMKDIMIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEAD
SGRVLYEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFDKKTYSVQDLLTATLVA
SSNSAAIALAEKVAGSELHFVNQMREQLSHWGITSGKILNASGLPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLED
FPEILEITKQTEVNFAGNSIKSFNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTR
FEQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVKELPVSVAEDVTIILQQGEQVPKPKQFMISETSLLAPITKG
EVVAYLTSPRITDQSVRYLKEPKRIPLKASQSLKKASDLQLWWRDFLEKRR

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=365, Percent_Identity=30.6849315068493, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786851, Length=349, Percent_Identity=27.5071633237822, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87082022, Length=381, Percent_Identity=26.509186351706, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 49947; Mature: 49947

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSQGTCFMSLFKLLKVCATILPSKFLRIFVIIVTMKDIMIKRWVILFFMVLTCSGFGK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TVLAADFQVGAEHAIVVEADSGRVLYEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLS
EEEEECCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEC
DQVNLSDYAFELTKDRSLSNVPFDKKTYSVQDLLTATLVASSNSAAIALAEKVAGSELHF
CCCCCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCHHHH
VNQMREQLSHWGITSGKILNASGLPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLED
HHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FPEILEITKQTEVNFAGNSIKSFNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENG
HHHHHHHHHHCCCEECCCHHHHHHHHCCCHHCCCCCCCCCCCCCHHHCCCEEEEEECCCC
MRVITVILNADGSDKNQNTRFEQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVK
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
ELPVSVAEDVTIILQQGEQVPKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLK
HCCCHHHHHHHHEECCCCCCCCCHHHEECCHHHCCCCCCCCEEEEECCCCCCHHHHHHHH
EPKRIPLKASQSLKKASDLQLWWRDFLEKRR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSQGTCFMSLFKLLKVCATILPSKFLRIFVIIVTMKDIMIKRWVILFFMVLTCSGFGK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TVLAADFQVGAEHAIVVEADSGRVLYEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLS
EEEEECCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEC
DQVNLSDYAFELTKDRSLSNVPFDKKTYSVQDLLTATLVASSNSAAIALAEKVAGSELHF
CCCCCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCHHHH
VNQMREQLSHWGITSGKILNASGLPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLED
HHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FPEILEITKQTEVNFAGNSIKSFNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENG
HHHHHHHHHHCCCEECCCHHHHHHHHCCCHHCCCCCCCCCCCCCHHHCCCEEEEEECCCC
MRVITVILNADGSDKNQNTRFEQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVK
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
ELPVSVAEDVTIILQQGEQVPKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLK
HCCCHHHHHHHHEECCCCCCCCCHHHEECCHHHCCCCCCCCEEEEECCCCCCHHHHHHHH
EPKRIPLKASQSLKKASDLQLWWRDFLEKRR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370539; 6780559; 111240 [H]