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The map label for this gene is yehU [C]

Identifier: 94994331

GI number: 94994331

Start: 890495

End: 892144

Strand: Direct

Name: yehU [C]

Synonym: MGAS10750_Spy0935

Alternate gene names: 94994331

Gene position: 890495-892144 (Clockwise)

Preceding gene: 94994330

Following gene: 94994332

Centisome position: 45.97

GC content: 35.58

Gene sequence:

>1650_bases
ATGCGAGGTGAACAGGTGGAAGAACATTTTAAAAAACAATTACAAGATGATATTTCTAGACATTTTTCGTACCAATCGTT
AATGTTATCATTGTTGCTAATTGGTCTTTTTATTATTTTTTCATTAGCGCCACAACAATTAGGCCTCTATCGTGATATCA
ATGCCACTGCAACCCGTTATCACCGTTTGATTAGCAAACAAGAAGCCTTGCTAGATGAATTAGGGAAAAATAGCTTACTA
CCTTTTTTAAATAAAAACCTCAGCACTGCTGATTTAAGCAAGCACTATTTTCATTTGCGCCATAGCAGCCAAACGTCACC
AGAACTTTTACTATTTTCACCTAATCAAGGCCTTTTATTTGCTAGTAACCCACATTTAGGAAATGTTTTTAGTAAATCTG
TTTATATTCAAGAAGTCTTGAGAGCAGCTCATCCTCCAAAAACCTTGTTTAAAGTTGCTATGGATAGTGAAGATGGTCAC
TACTTGATGATCATTAAGCCAATGATAGATCAAAACCAACTAAAGGGATATGCTTTTTTAGTGATGAGTGGCAAAGATTT
TCTTCATCCTACAAAAACATTGACGTCAGAGTTGGTCATTGCTGATAAGCTGGACAACACGGTTACGTTTTCCAATCGTG
AGTTTATAGCATCTAGTCTAGATAAGATCAATAGCCAGTATTTACACCATTATTTTGTTTTTCAAGATAATCGAGCCTTT
ATCACAAGAAAGGTTGCCTTACAAGGAGGCCTTTGGCTTTACATGTATAGGCCCTTGATTCCAATGGTATCGGTGATGTT
ATTTTCACTTATTTCATCAGCTGTTATCTTTGTGATTTTGCAACGTAAATCAAGTGGTTTAGCTAACCGAATTGCAGCTA
AAAATTCAAGAGCAATCAATCAAATGGTTAGAGATATGAGTGCGATCTCTCGGCAAGAAAAAAGACGTATTGACCTTGAG
AGTCAAGATGAATTTCAATATTTATCTGATCAAATCAATCAAATGGTAGAGCGATTGCAACAGTTACATGATAAAACGTT
AGATTTGGAAACTCAAAAATTATTATTTGAAAAACGGATGTTAGAAGCTCAATTCAATCCGCATTTCCTCTACAATACGC
TAGAAACCATTTTGATTACGAGCCATTATGATTCTGCCCTAACAGAAAAAATTGTTATCCAATTGACAAAATTGTTGCGG
TATAGTCTCACGGATTCTAGCAAACCTGTCTTGCTCAAAGATGATTTAAGTGTCATCGAGTCTTATTTAGTGATTAATCA
GGTGCGGTTTGAAGAATTGCAATATAGCATTAACCTATCCCCAGACCTTGATAGTCTTGCAGTGCCTAAATTGTTCTTGT
TACCTTTGATAGAAAATGCCATCAAATATGGCTTGAAAGAACGACACGATGTCAAGATTAACATTGCTTGTTATTATCAA
GATGACCACATTATTTTTTCTGTGAGAGATAATGGTTCGGGAATTGATGCTCATCACCAAAAAGTGATTCGAGAGCAATT
GGAAGCTGGAGAGTCACACCATGGGTTAATTAACTCTTATCGTCGGCTTAAGTATCATTTTTCAGAAGTATCCTTGGTTT
TTGATCAAGGTGATAAACAGTTTAATGTTAGTTACCATGTTAAGGAGTAG

Upstream 100 bases:

>100_bases
TTCTTGTTTTGCTTACCTTTTTCCTTTTAAGATGATGAGACTTGTTTTGATGAAAAACGTAGTAGCATTAAGAAATTTGT
TATAATGAAGGGAGCTTAAG

Downstream 100 bases:

>100_bases
TCTATGTACAAATTAGTCATTATTGAAGATGAACATATTATTAGGAAATGGTTGCGATACGCTATTGATTATAAAGCTTT
AGATATTTTGGTCATTGGCG

Product: two-component sensor kinase yesM

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLYRDINATATRYHRLISKQEALLDELGKNSLL
PFLNKNLSTADLSKHYFHLRHSSQTSPELLLFSPNQGLLFASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGH
YLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVIADKLDNTVTFSNREFIASSLDKINSQYLHHYFVFQDNRAF
ITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAINQMVRDMSAISRQEKRRIDLE
SQDEFQYLSDQINQMVERLQQLHDKTLDLETQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLR
YSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLAVPKLFLLPLIENAIKYGLKERHDVKINIACYYQ
DDHIIFSVRDNGSGIDAHHQKVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE

Sequences:

>Translated_549_residues
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLYRDINATATRYHRLISKQEALLDELGKNSLL
PFLNKNLSTADLSKHYFHLRHSSQTSPELLLFSPNQGLLFASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGH
YLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVIADKLDNTVTFSNREFIASSLDKINSQYLHHYFVFQDNRAF
ITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAINQMVRDMSAISRQEKRRIDLE
SQDEFQYLSDQINQMVERLQQLHDKTLDLETQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLR
YSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLAVPKLFLLPLIENAIKYGLKERHDVKINIACYYQ
DDHIIFSVRDNGSGIDAHHQKVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE
>Mature_549_residues
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLYRDINATATRYHRLISKQEALLDELGKNSLL
PFLNKNLSTADLSKHYFHLRHSSQTSPELLLFSPNQGLLFASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGH
YLMIIKPMIDQNQLKGYAFLVMSGKDFLHPTKTLTSELVIADKLDNTVTFSNREFIASSLDKINSQYLHHYFVFQDNRAF
ITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAINQMVRDMSAISRQEKRRIDLE
SQDEFQYLSDQINQMVERLQQLHDKTLDLETQKLLFEKRMLEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLR
YSLTDSSKPVLLKDDLSVIESYLVINQVRFEELQYSINLSPDLDSLAVPKLFLLPLIENAIKYGLKERHDVKINIACYYQ
DDHIIFSVRDNGSGIDAHHQKVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQFNVSYHVKE

Specific function: Probable member of the two-component regulatory system SE_0166/SE_0165. May activate SE_0165 by phosphorylation [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=149, Percent_Identity=32.8859060402685, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788723, Length=216, Percent_Identity=30.0925925925926, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR010559 [H]

Pfam domain/function: PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63490; Mature: 63490

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLYRDINATATRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHH
HRLISKQEALLDELGKNSLLPFLNKNLSTADLSKHYFHLRHSSQTSPELLLFSPNQGLLF
HHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHEEECCCCCCCCEEEECCCCCEEE
ASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGHYLMIIKPMIDQNQLKGYAFL
ECCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEEECCCCCCCCCCEEEE
VMSGKDFLHPTKTLTSELVIADKLDNTVTFSNREFIASSLDKINSQYLHHYFVFQDNRAF
EECCCCCCCCHHHHHHHHHEEECCCCCEEECCHHHHHHHHHHHHHHHEEEEEEEECCCEE
ITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAIN
EEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHH
QMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQMVERLQQLHDKTLDLETQKLLFEKRM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLRYSLTDSSKPVLLKDDLSVIE
HHHCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
SYLVINQVRFEELQYSINLSPDLDSLAVPKLFLLPLIENAIKYGLKERHDVKINIACYYQ
HHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEE
DDHIIFSVRDNGSGIDAHHQKVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQ
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCE
FNVSYHVKE
EEEEEEECC
>Mature Secondary Structure
MRGEQVEEHFKKQLQDDISRHFSYQSLMLSLLLIGLFIIFSLAPQQLGLYRDINATATRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHH
HRLISKQEALLDELGKNSLLPFLNKNLSTADLSKHYFHLRHSSQTSPELLLFSPNQGLLF
HHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHEEECCCCCCCCEEEECCCCCEEE
ASNPHLGNVFSKSVYIQEVLRAAHPPKTLFKVAMDSEDGHYLMIIKPMIDQNQLKGYAFL
ECCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEEECCCCCCCCCCEEEE
VMSGKDFLHPTKTLTSELVIADKLDNTVTFSNREFIASSLDKINSQYLHHYFVFQDNRAF
EECCCCCCCCHHHHHHHHHEEECCCCCEEECCHHHHHHHHHHHHHHHEEEEEEEECCCEE
ITRKVALQGGLWLYMYRPLIPMVSVMLFSLISSAVIFVILQRKSSGLANRIAAKNSRAIN
EEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHH
QMVRDMSAISRQEKRRIDLESQDEFQYLSDQINQMVERLQQLHDKTLDLETQKLLFEKRM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LEAQFNPHFLYNTLETILITSHYDSALTEKIVIQLTKLLRYSLTDSSKPVLLKDDLSVIE
HHHCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
SYLVINQVRFEELQYSINLSPDLDSLAVPKLFLLPLIENAIKYGLKERHDVKINIACYYQ
HHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEE
DDHIIFSVRDNGSGIDAHHQKVIREQLEAGESHHGLINSYRRLKYHFSEVSLVFDQGDKQ
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCE
FNVSYHVKE
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]