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The map label for this gene is elaC [H]

Identifier: 94994215

GI number: 94994215

Start: 792602

End: 793531

Strand: Direct

Name: elaC [H]

Synonym: MGAS10750_Spy0819

Alternate gene names: 94994215

Gene position: 792602-793531 (Clockwise)

Preceding gene: 94994214

Following gene: 94994216

Centisome position: 40.92

GC content: 41.08

Gene sequence:

>930_bases
ATGGAATTACAATTTTTAGGAACTGGAGCTGGTCAACCAGCCAAGCAGCGCAATGTGTCAAGTCTTGCCTTGAAATTACT
AGACGAAATCAATGAAGTCTGGATGTTTGATTGCGGTGAAGGAACGCAAAGACAAATTTTAGAAACGACGATTAAGCCAC
GAAAAATAAGAAAGATTTTCATTACTCATTTGCATGGGGACCACATTTTTGGATTACCAGGATTTTTATCAAGTCGGTCT
TTTCAAGCTAGTGAAGAACAGACAGATCTTGATATTTATGGACCAATTGGCATTAAAACTTACGTGTTAACTAGTCTAAA
AGTTTCTGGAGCGCGTGTACCTTATCAGATCCATTTTCATGAATTTGATGACAAATCATTAGGTAAAATAATGGAAACAG
ATAAGTTTGTGGTCTATGCAGAGCGTCTGGCGCATACCATTTTTTGCATGGGTTATCGAGTAGTTCAAAAAGACTTAGAA
GGAACCCTAGACGCAGAAGCCTTAAAAGCAGCGGGTGTTCCCTTCGGACCACTCTTTGGCAAAATTAAAAATGGTCAAGA
CGTTGAGTTGGAAGACGGCCGCCTGATTTGTGCCAAAGATTATATTTCTGCCCCTAAAAAAGGCAAAATCATCACCATTA
TCGGCGATACGCGCAAAACGTCTGCCAGTGTTAAACTCGCTAAAGATGCAGATGTTTTGGTTCATGAATCCACCTATGGT
AAGGGTGACGAGCGGATTGCGAGAAATCACGGGCATTCTACCAACATGCAGGCAGCACAAATCGCTCATGAAGCAGGCGC
AAAACGCCTCTTGCTCAATCATGTATCAGCTCGCTTCTTAGGGCGTGATTGTCGCCAGATGGAAAAAGATGCCGCCACTA
TATTTGAAAATGTTAAAATGGTACAAGATTTAGAGGAAGTGATTATTTAA

Upstream 100 bases:

>100_bases
AGTTATGGGCTCTTAGCCAAACATTTTCTGGTCAAAAGTATTATGATTTTGCCCAACGAGAATTTATGATTTACATCACC
CAATAGAAAGAATAGATTGA

Downstream 100 bases:

>100_bases
TGGCACAAAGAATCATTGTTATCACGGGAGCTTCTGGAGGACTGGCTCAGGCAATTGTTAAGCAGTTACCCAAGGAAGAC
AGCTTGATTTTATTAGGACG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRS
FQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLE
GTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYG
KGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII

Sequences:

>Translated_309_residues
MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRS
FQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLE
GTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYG
KGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII
>Mature_309_residues
MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRS
FQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLE
GTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYG
KGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=351, Percent_Identity=35.6125356125356, Blast_Score=207, Evalue=9e-54,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=44.9180327868852, Blast_Score=265, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 34400; Mature: 34400

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIF
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCHHHHHEEE
ITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFH
EEEECCCEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCEEEEEE
EFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFG
ECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHH
KIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYG
CCCCCCCEEECCCEEEEEHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCC
KGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKM
CCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQDLEEVII
HHHHHHHCC
>Mature Secondary Structure
MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIF
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCHHHHHEEE
ITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFH
EEEECCCEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCEEEEEE
EFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFG
ECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHH
KIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYG
CCCCCCCEEECCCEEEEEHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEEECCCC
KGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKM
CCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQDLEEVII
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]