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The map label for this gene is rpiA [H]

Identifier: 94994183

GI number: 94994183

Start: 761211

End: 761894

Strand: Direct

Name: rpiA [H]

Synonym: MGAS10750_Spy0787

Alternate gene names: 94994183

Gene position: 761211-761894 (Clockwise)

Preceding gene: 94994181

Following gene: 94994184

Centisome position: 39.3

GC content: 42.98

Gene sequence:

>684_bases
ATGGAAGCACTCAAAAAAATTGCCGGTGTTACCGCTGCGCAATATGTGACTGATGGCATGACCATTGGGCTTGGAACTGG
GTCAACGGCTTACTATTTTGTTGAGGAAATTGGCCGTCGCGTAAAGCAAGAAGGACTGCAAGTGGTTGGTGTGACTACGT
CAAGTGTGACTAGCAAGCAAGCAGAAGGCTTAGGCATTCCTTTAAAATCGATAGATGATATTGATAGCATTGACCTCACC
GTAGATGGTGCTGATGAAGTGGATAAGGATTTCAATGGAATCAAGGGTGGCGGCGCAGCCTTACTAATGGAAAAAATTGT
TGCAACACCAACAAAAGAATACATCTGGGTTGTTGATGCTTCTAAAATGGTAGAGCATCTGGGTGCCTTTAAGTTACCAG
TCGAAGTCGTTCAATATGGTGCTGATCGTTTGTTCCGTGTCTTTGAAAAAGCTGGTTACAAACCGTCTTTTCGTATGAAA
GGTGATAGTCGTTTGGTGACAGACATGCAAAACTATATTATTGATCTTGATTTGGGTTGTATTAAAGATCCTGTTGCTTT
TGGTCACCTGCTAGATGGAACAGTTGGTGTTGTGGAACACGGTCTCTTTAATGGTATGGTTGATAAGGTGATTGTTGCTA
GTAAAGACGGCGTTACTGTTTTAGAAGCGCCTAAAGCAGGCTAG

Upstream 100 bases:

>100_bases
TTAGCTGTCAATGAGAGAAAAACAAATGTTTTCATTAACAAGTTGGCGCTTTCATGGTATAATAAAGTGCTAAGACGCAA
TTCTATTATAAGGGGGAATC

Downstream 100 bases:

>100_bases
TCTTAGCATATAACAGTGTTAATATATTTTATAGGTATTGGGGAGTCAACCGTAACCTCCCCTAGATTGGAGACTTATGT
CAAAATTTAATCGTATTCAC

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEGLGIPLKSIDDIDSIDLT
VDGADEVDKDFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPKAG

Sequences:

>Translated_227_residues
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEGLGIPLKSIDDIDSIDLT
VDGADEVDKDFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPKAG
>Mature_227_residues
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEGLGIPLKSIDDIDSIDLT
VDGADEVDKDFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPKAG

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI94536842, Length=231, Percent_Identity=35.4978354978355, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1789280, Length=220, Percent_Identity=39.0909090909091, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17551758, Length=225, Percent_Identity=36.4444444444444, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324669, Length=214, Percent_Identity=35.981308411215, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281364072, Length=221, Percent_Identity=32.1266968325792, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004788
- InterPro:   IPR020672 [H]

Pfam domain/function: PF06026 Rib_5-P_isom_A [H]

EC number: =5.3.1.6 [H]

Molecular weight: Translated: 24263; Mature: 24263

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQ
CHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH
AEGLGIPLKSIDDIDSIDLTVDGADEVDKDFNGIKGGGAALLMEKIVATPTKEYIWVVDA
HCCCCCCHHCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEEH
SKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMKGDSRLVTDMQNYIIDLDLGC
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHEEECCCCH
IKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPKAG
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCCCC
>Mature Secondary Structure
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQ
CHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH
AEGLGIPLKSIDDIDSIDLTVDGADEVDKDFNGIKGGGAALLMEKIVATPTKEYIWVVDA
HCCCCCCHHCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEEH
SKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMKGDSRLVTDMQNYIIDLDLGC
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHEEECCCCH
IKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPKAG
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]