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The map label for this gene is mvaK1 [H]

Identifier: 94994170

GI number: 94994170

Start: 747548

End: 748426

Strand: Direct

Name: mvaK1 [H]

Synonym: MGAS10750_Spy0774

Alternate gene names: 94994170

Gene position: 747548-748426 (Clockwise)

Preceding gene: 94994169

Following gene: 94994171

Centisome position: 38.59

GC content: 42.55

Gene sequence:

>879_bases
ATGAACGAAAACATTGGATATGGTAAGGCACACAGTAAGATCATTTTGATAGGTGAGCATGCTGTTGTGTATGGCTACCC
AGCTATTGCTTTGCCTTTAACAGATATTGAGGTGGTTTGTCATATTTTTCCAGCTGATAAACCATTGGTCTTTGATTTTT
ATGATACTCTATCAACAGCCATTTATGCTGCCTTGGATTATTTGCAGCGACTACAAGAACCAATTGCTTATGAGATTGTT
TCACAAGTGCCACAAAAGCGTGGTATGGGATCTTCGGCAGCCGTTTCTATTGCAGCTATTAGAGCCGTTTTTTCTTATTG
TCAAGAACCCCTCTCGGATGATTTGTTGGAAATTTTAGTCAACAAGGCAGAAATTATTGCCCACACCAATCCTAGTGGTT
TAGATGCCAAGACATGCCTTAGTGACCATGCCATTAAGTTTATCCGAAACATTGGCTTTGAAACTATCGAAATCGCCTTA
AATGGTTATCTTATCATTGCAGATACAGGGATTCACGGTCATACACGTGAGGCCGTCAATAAGGTAGCACAGTTTGAGGA
AACGAATTTGCCCTATCTGGCTAAACTAGGAGCTTTGACACAAGCCCTTGAAAGAGCGATTAACCAAAAAAATAAGGTTG
CTATCGGTCAGCTCATGACACAAGCGCACTCTGCTTTAAAGGCCATTGGCGTTAGCATCAGTAAGGCTGACCAACTTGTG
GAGGCTGCCCTAAGAGCAGGTGCTTTAGGCGCTAAGATGACAGGCGGTGGCTTGGGTGGCTGTATGATTGCCCTAGCAGA
TACCAAAGACATGGCCGAAAAAATCAGTCACAGATTAAAAGAAGAAGGAGCCGTAAACACGTGGATCCAAATGTTATAA

Upstream 100 bases:

>100_bases
AAGAAATGATTTTAAAAAGATATATCATCGCATTTTCTAATCATTTAGTGTAAAATAGTAAGGTAAAAGTTTAGAAGAAT
TAGTAATGAAAAGATAAAAA

Downstream 100 bases:

>100_bases
CCGTAACATCCTATGCTAACATTGCTATTATCAAATATTGGGGAAAAGAGAATCAAGCTAAGATGATTCCTTCGACCTCT
AGCATTTCTTTGACTTTGGA

Product: Mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIV
SQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIAL
NGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISKADQLV
EAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML

Sequences:

>Translated_292_residues
MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIV
SQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIAL
NGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISKADQLV
EAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML
>Mature_292_residues
MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIV
SQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIAL
NGYLIIADTGIHGHTREAVNKVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISKADQLV
EAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI78707210, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 31456; Mature: 31456

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTA
CCCCCCCCCCCCEEEEEECCEEEEECCCCEECHHHHHHHEEECCCCCCEEEHHHHHHHHH
IYAALDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
NKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIALNGYLIIADTGIHGHTREAVN
HHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHHHHHH
KVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISKADQLV
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML
HHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MNENIGYGKAHSKIILIGEHAVVYGYPAIALPLTDIEVVCHIFPADKPLVFDFYDTLSTA
CCCCCCCCCCCCEEEEEECCEEEEECCCCEECHHHHHHHEEECCCCCCEEEHHHHHHHHH
IYAALDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAIRAVFSYCQEPLSDDLLEILV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
NKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIALNGYLIIADTGIHGHTREAVN
HHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHHHHHH
KVAQFEETNLPYLAKLGALTQALERAINQKNKVAIGQLMTQAHSALKAIGVSISKADQLV
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EAALRAGALGAKMTGGGLGGCMIALADTKDMAEKISHRLKEEGAVNTWIQML
HHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]