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The map label for this gene is sptS [H]

Identifier: 94994169

GI number: 94994169

Start: 745995

End: 747254

Strand: Direct

Name: sptS [H]

Synonym: MGAS10750_Spy0773

Alternate gene names: 94994169

Gene position: 745995-747254 (Clockwise)

Preceding gene: 94994168

Following gene: 94994170

Centisome position: 38.51

GC content: 34.68

Gene sequence:

>1260_bases
TTGTTTATTAGAAAAATAGGAGGTGACATGTTTAATCGTATCCGTATTCGTTTTATCATGATTGCTTCTATTGCCATTTT
TATTATTTTAAGTTCAATTGTTGGTATTATTAACACGGCACGCTGTTACCAAAGTCAACAAGAAATTAACCGTATTTTAC
ATTTAATTTCCTCAAATAAAGGTAAATTACCTGACACTACGGAAAGCTCTAAACGACTTGGAACGAAACTGTCTGAAGAT
AGCCTAAGCCAGTTTCGGTATTATAGTGTCATTTTTAATGCTAATGGACATCTACTTTCTTCTAATACTGCTAATATTTC
AGCTTTAGATAGAGAAGAAGCCCAATATTTTGCTAGACTTTTTGCTAAGTCTGGGGAAGAAAAAGGCAGTTACCGTCACC
AAGATAGTGTTTATTCGTACTTGATTACTCAGCTGCCAAATGAAGAAAAACTGGTTGTAATTTTAGATACTACCTTTTAT
TTTCGTAGTGTAGGAGATTTATTAGCTGTTTCAATGATGTTGGCCTTTGGAGGATTTATCTTTTTTGTTGTTTTAGTGAG
TCTTTTTTCCGGTATGGTCATCAAACCTTTTGTCCAAAATTATGAGAAGCAGCGTCGCTTTATTACTAATGCAGGCCACG
AGTTAAAAACACCACTAGCCATTATCTCAGCCAATAATGAATTGGTCGAATTAATGACTGGAGAATCAGAATGGACCAAG
AGTACAAGTGATCAGGTGAAGCGATTGACAGGCTTGATTAATCAAATGATTACTTTGGCTCGTTTGGAGGAACAGCCAGA
TGTGGTATTACATATGGTAGACTTTTCAGCTATTGCTCAAGATGCAGCTGAAGATTTTAAGAGTCTGGTTTTGAAAGATG
GTAAACGTTTTGATTTGACGATTCAGCCGAATATTATGATTAAAGCGGAGGAAAAGTCATTATTTGAACTTGTGACAATT
TTAGTTGATAATGCCAATAAATATTGTGATCCTAAAGGCTTGGTCAAGGTATCTTTAACCACTATTGGAAGAAGACGAAA
ACGAGCGAAATTAGAAGTTTCTAATACCTATTTGGAAGGAAAATCCATTGATTACAGCCGCTTTTTTGAACGCTTTTATC
GCGAAGACGAATCCCATAATAGCAAAGAAAAAGGTTATGGAATTGGTTTATCTATGGCAGAAAGTATGGTTAAGTTATTT
AAAGGAACGATAACTGTAAATTATAAAAACGATGCTATTGTTTTTACAGTGGTGATTTGA

Upstream 100 bases:

>100_bases
ATGATACTTCTATTGTTTGGGTTTATATTTCTTATCTTCGTCAAAAATTATTAGCTATTCAAGCAAATGTCATTATTGCA
GGTGATAAAGATACTAGCTA

Downstream 100 bases:

>100_bases
CTTAAACATTTTTCAGTACCTTTAGCTAGTAATAATGTCTAGGTAAAGGTAATAAACGATGCTTAACCAGCCCATGAGGC
TGGTTTTTAACGTTTAATTT

Product: two-component system histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MFIRKIGGDMFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSNKGKLPDTTESSKRLGTKLSED
SLSQFRYYSVIFNANGHLLSSNTANISALDREEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFY
FRSVGDLLAVSMMLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNELVELMTGESEWTK
STSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLTIQPNIMIKAEEKSLFELVTI
LVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLEGKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLF
KGTITVNYKNDAIVFTVVI

Sequences:

>Translated_419_residues
MFIRKIGGDMFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSNKGKLPDTTESSKRLGTKLSED
SLSQFRYYSVIFNANGHLLSSNTANISALDREEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFY
FRSVGDLLAVSMMLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNELVELMTGESEWTK
STSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLTIQPNIMIKAEEKSLFELVTI
LVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLEGKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLF
KGTITVNYKNDAIVFTVVI
>Mature_419_residues
MFIRKIGGDMFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSNKGKLPDTTESSKRLGTKLSED
SLSQFRYYSVIFNANGHLLSSNTANISALDREEAQYFARLFAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFY
FRSVGDLLAVSMMLAFGGFIFFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNELVELMTGESEWTK
STSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLTIQPNIMIKAEEKSLFELVTI
LVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLEGKSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLF
KGTITVNYKNDAIVFTVVI

Specific function: Member of the two-component regulatory system dltS/dltR. Regulates the expression of the dlt operon. Probably phosphorylates dltR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=215, Percent_Identity=25.1162790697674, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=29.2576419213974, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47588; Mature: 47588

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIRKIGGDMFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSNK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKLPDTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLSSNTANISALDREEAQYFARL
CCCCCCCCHHHHHCCCCCHHHHHHHEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHH
FAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFYFRSVGDLLAVSMMLAFGGFI
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
FFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNELVELMTGESEWTK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCHHCC
STSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLT
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IQPNIMIKAEEKSLFELVTILVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLEG
ECCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHCEEEEEEEEECC
KSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLFKGTITVNYKNDAIVFTVVI
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCEEEEEEEC
>Mature Secondary Structure
MFIRKIGGDMFNRIRIRFIMIASIAIFIILSSIVGIINTARCYQSQQEINRILHLISSNK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKLPDTTESSKRLGTKLSEDSLSQFRYYSVIFNANGHLLSSNTANISALDREEAQYFARL
CCCCCCCCHHHHHCCCCCHHHHHHHEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHH
FAKSGEEKGSYRHQDSVYSYLITQLPNEEKLVVILDTTFYFRSVGDLLAVSMMLAFGGFI
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
FFVVLVSLFSGMVIKPFVQNYEKQRRFITNAGHELKTPLAIISANNELVELMTGESEWTK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCHHCC
STSDQVKRLTGLINQMITLARLEEQPDVVLHMVDFSAIAQDAAEDFKSLVLKDGKRFDLT
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IQPNIMIKAEEKSLFELVTILVDNANKYCDPKGLVKVSLTTIGRRRKRAKLEVSNTYLEG
ECCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHCEEEEEEEEECC
KSIDYSRFFERFYREDESHNSKEKGYGIGLSMAESMVKLFKGTITVNYKNDAIVFTVVI
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11591677; 12354221 [H]