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The map label for this gene is apbA [H]

Identifier: 94994146

GI number: 94994146

Start: 727465

End: 728388

Strand: Direct

Name: apbA [H]

Synonym: MGAS10750_Spy0750

Alternate gene names: 94994146

Gene position: 727465-728388 (Clockwise)

Preceding gene: 94994145

Following gene: 94994147

Centisome position: 37.55

GC content: 39.5

Gene sequence:

>924_bases
ATGTTAGTTTATATTGCTGGCTCAGGAGCCATGGGGTGCCGTTTTGGTTACCAAATTTCAAAAACAAATAACGATGTGAT
TTTGTTAGATAACTGGGAAGATCATATCAATGCCATTAAAGAAAACGGGTTGATTGTAACAGGTGATGTGGAAGAAACAG
TTAAGCTTCCTATTATGAAATCGACTGAAGCCACTCAAGAAGCCGATTTGATTATCTTGTTTACAAAAGCAATGCAGTTG
CCACAAATGCTTCAAGACATTAAAGGCATTATTGGAAAAGAAACCAAAGTGCTTTGCCTTTTAAATGGTCTTGGACACGA
AGACGTTATTCGTCAGTACATTCCAGAGCACAACATTTTGATGGGGGTCACTGTCTGGACTGCTGGTCTAGAAGGACCAG
GTCGTGCTCATCTTCAAGGAGTTGGTGCTCTTAACTTACAAAGTATGGATCCAAACAATCAAGATGCGGGACATCAAGTG
GCTGACTTGCTAAATAAAGCTAACTTAAATGCGACTTATGATGAGAATGTTGTGCCAAACATCTGGCGAAAAGCTTGCGT
GAATGGTACCATGAATTCGACTTGTGCTCTTTTAGATTGTACGATTGGCGAATTATTTGCCAGTGAAGATGGTCTCAAAA
TGGTAAAAGAAATCATCCATGAGTTTGTTATCGTTGGTCAAGCAGAAGGTGTCGAACTAAACGAAGAAGAAATCACACAA
TATGTAATGGATACATCTGTTAAAGCTGCTCACCATTACCCATCAATGCACCAAGACCTTGTGCAAAATCACCGATTGAC
TGAAATTGATTTTATCAATGGTGCAGTCAATACCAAAGGTGAAAAGCTTGGTATCAATACTCCATACTGCCGTATGATTA
CAGAGCTAGTTCACGCTAAAGAAGCAGTGTTGAACATCCAATAA

Upstream 100 bases:

>100_bases
TCCGTTTGCGGTTGCTTTTGCGGCGCATAAGGTTTCTAAAGATATTCTAAAACTTTATAAAGAAGACATTTTCGTCTTTG
AAGGCTAATAGGAGGAAAAT

Downstream 100 bases:

>100_bases
ACGCTATCAAATCGTTACACTCAATATTATGGCTAAAGCTTTAATATTGAGTTTTTTGTTATGCTGATAGTATTTTTCTT
AGGCATCATTATTTGTGAGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLIVTGDVEETVKLPIMKSTEATQEADLIILFTKAMQL
PQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQV
ADLLNKANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQ
YVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAKEAVLNIQ

Sequences:

>Translated_307_residues
MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLIVTGDVEETVKLPIMKSTEATQEADLIILFTKAMQL
PQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQV
ADLLNKANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQ
YVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAKEAVLNIQ
>Mature_307_residues
MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLIVTGDVEETVKLPIMKSTEATQEADLIILFTKAMQL
PQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQV
ADLLNKANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQ
YVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAKEAVLNIQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=307, Percent_Identity=25.4071661237785, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33845; Mature: 33845

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLIVTGDVEETVKLPIMK
CEEEEECCCCCCEEECEEEECCCCCEEEEECCHHHHHHHHHCCEEEECCHHHHEECCEEE
STEATQEADLIILFTKAMQLPQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNIL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCEE
MGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQVADLLNKANLNATYDENVVPN
EEEEEEECCCCCCCCHHEEECCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH
IWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQ
HHHHHHCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHH
YVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAK
HHHHCCHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHH
EAVLNIQ
HHHEECC
>Mature Secondary Structure
MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLIVTGDVEETVKLPIMK
CEEEEECCCCCCEEECEEEECCCCCEEEEECCHHHHHHHHHCCEEEECCHHHHEECCEEE
STEATQEADLIILFTKAMQLPQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNIL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCEE
MGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQVADLLNKANLNATYDENVVPN
EEEEEEECCCCCCCCHHEEECCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH
IWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQ
HHHHHHCCCCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHH
YVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAK
HHHHCCHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHH
EAVLNIQ
HHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]