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The map label for this gene is endA [H]

Identifier: 94994066

GI number: 94994066

Start: 642774

End: 643364

Strand: Direct

Name: endA [H]

Synonym: MGAS10750_Spy0670

Alternate gene names: 94994066

Gene position: 642774-643364 (Clockwise)

Preceding gene: 94994065

Following gene: 94994067

Centisome position: 33.18

GC content: 41.29

Gene sequence:

>591_bases
TTGAGAGGAAGTATGTTAACAAGGAAAAAACGAAAAAGGGTGCTTAATTCCTTCTTATTGATTTTGTTAGTGTTGGGGTC
TAACTGCCTTGCTAAGAGTGATTTCATAGCTAGCAATCATCCTATCAAGCAACTTTATCAGACTCTTGTTGGGGAGAAGA
AAAAATCATTACTCACACATAATAATTTGCCCGCTGATGTTCCCACAGAAGCTCTGGCGGCATCGGTATTAACACCATCA
ATCAAAAAGCAACTAGGTCCAAATGTTCAGTGGAATGGAGCAGGCGCCTATATTATCAACAGGAACAAAACAGATTTAAC
TGCTAAGGTAGCCAGTCCGCCTTATGCCAACAATGAAACCAAATGGGTGCAAGAGCAAAAGGTTCCTACTAGAGCTAATG
CCTTACTTACTAAGTCGACACGACAGTATCGAAATCGCTATCAAACGAACAATGCTTATCGTACCTTTAAGCCAGCAGGT
TGGCACCGATTGCACCACTTAAAAGGAAGTTATGATCACGCGGTTGATAGAGGGCATTTGCTAGGTTATGCTTTAGTTGG
TGGACTGAAAGGTTTTGATGCTTACCAGTAA

Upstream 100 bases:

>100_bases
GAGATGGCCATAGTCCATGGCATATTTTATCTATGGATAAGTGGGCAGAGTTAGTGAATAAATTTACTGGAAAGTAGGCC
TTGCCTACTTTTTATAGCAT

Downstream 100 bases:

>100_bases
TCCTGATAATATTGCCACTCAACTAAGTTGGGCTAATCAAGTAAATAAACCCTACTCGACAGGTCAGAACTACTATGAAG
GTTTAGTACGTCGTGCTTTG

Product: DNA-entry nuclease

Products: NA

Alternate protein names: Competence-specific nuclease [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MRGSMLTRKKRKRVLNSFLLILLVLGSNCLAKSDFIASNHPIKQLYQTLVGEKKKSLLTHNNLPADVPTEALAASVLTPS
IKKQLGPNVQWNGAGAYIINRNKTDLTAKVASPPYANNETKWVQEQKVPTRANALLTKSTRQYRNRYQTNNAYRTFKPAG
WHRLHHLKGSYDHAVDRGHLLGYALVGGLKGFDAYQ

Sequences:

>Translated_196_residues
MRGSMLTRKKRKRVLNSFLLILLVLGSNCLAKSDFIASNHPIKQLYQTLVGEKKKSLLTHNNLPADVPTEALAASVLTPS
IKKQLGPNVQWNGAGAYIINRNKTDLTAKVASPPYANNETKWVQEQKVPTRANALLTKSTRQYRNRYQTNNAYRTFKPAG
WHRLHHLKGSYDHAVDRGHLLGYALVGGLKGFDAYQ
>Mature_196_residues
MRGSMLTRKKRKRVLNSFLLILLVLGSNCLAKSDFIASNHPIKQLYQTLVGEKKKSLLTHNNLPADVPTEALAASVLTPS
IKKQLGPNVQWNGAGAYIINRNKTDLTAKVASPPYANNETKWVQEQKVPTRANALLTKSTRQYRNRYQTNNAYRTFKPAG
WHRLHHLKGSYDHAVDRGHLLGYALVGGLKGFDAYQ

Specific function: By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA/RNA non-specific endonuclease family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018524
- InterPro:   IPR001604 [H]

Pfam domain/function: PF01223 Endonuclease_NS [H]

EC number: 3.1.30.-

Molecular weight: Translated: 21979; Mature: 21979

Theoretical pI: Translated: 10.89; Mature: 10.89

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGSMLTRKKRKRVLNSFLLILLVLGSNCLAKSDFIASNHPIKQLYQTLVGEKKKSLLTH
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHC
NNLPADVPTEALAASVLTPSIKKQLGPNVQWNGAGAYIINRNKTDLTAKVASPPYANNET
CCCCCCCCHHHHHHHHHCHHHHHHCCCCCEECCCEEEEEECCCCCEEEEECCCCCCCCCC
KWVQEQKVPTRANALLTKSTRQYRNRYQTNNAYRTFKPAGWHRLHHLKGSYDHAVDRGHL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCHHHHHCCHHH
LGYALVGGLKGFDAYQ
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRGSMLTRKKRKRVLNSFLLILLVLGSNCLAKSDFIASNHPIKQLYQTLVGEKKKSLLTH
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHC
NNLPADVPTEALAASVLTPSIKKQLGPNVQWNGAGAYIINRNKTDLTAKVASPPYANNET
CCCCCCCCHHHHHHHHHCHHHHHHCCCCCEECCCEEEEEECCCCCEEEEECCCCCCCCCC
KWVQEQKVPTRANALLTKSTRQYRNRYQTNNAYRTFKPAGWHRLHHLKGSYDHAVDRGHL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCHHHHHCCHHH
LGYALVGGLKGFDAYQ
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2359120; 11463916 [H]