Click here to switch to the map view.

The map label for this gene is asnC [H]

Identifier: 94993952

GI number: 94993952

Start: 541302

End: 542648

Strand: Direct

Name: asnC [H]

Synonym: MGAS10750_Spy0556

Alternate gene names: 94993952

Gene position: 541302-542648 (Clockwise)

Preceding gene: 94993951

Following gene: 94993953

Centisome position: 27.94

GC content: 38.16

Gene sequence:

>1347_bases
ATGTCAAAAAAACTTATTTCAATTGTTGATGTTAAAGATTATGTTGGTCAAGAAGTTACTATTGGTGCTTGGGTTGCTAA
CAAATCAGGTAAAGGTAAGATTGCGTTTGTACAGTTACGCGATGGTTCTGCTTTTTTCCAAGGTGTCGCTTTTAAACCAA
ACTTCATTGAAAAATATGGTGAAGAATCAGGTCATGAAAAATTTGACGTTATTAAACGTCTCAACCAAGAAACATCTGTT
TATGTAACAGGGATTGTTAAAGAGGATGAGCGTTCTAAATTTGGCTATGAGCTTGATATTACTGACCTTGAAATCATTGG
AGAGTCACATGAATATCCTATAACTCCTAAAGAGCATGGGACAGACTTCTTGATGGACAACCGTCATCTTTGGTTGCGTT
CTCGTAAACAAATGGCTGTTATGCAAATTCGTAACGCTATTATTTATGCAACTTATGAATTCTTTGACCAAAATGGTTTT
ATCAAATTTGATAGCCCAATTTTATCAGAAAATGCAGCAGAAGATTCAACAGAGTTATTCGAAACAGACTATTTTGGGAA
ACCAGCATTTCTTAGCCAATCTGGTCAATTATACCTTGAAGCTGGAGCAATGGCTCTAGGCCGAGTTTTCGACTTTGGTC
CAGTCTTTCGTGCTGAAAAATCTAAAACACGTCGCCATTTAACAGAATTTTGGATGATGGATGCTGAGTATTCTTTCTTG
TCACATGAGGAATCACTTGACCTTCAAGAAGCTTATGTTAAAGCGTTGATCCAAGGCGTTCTAGATCGTGCGCCTCAAGC
ACTTGATATTTTAGAACGTGATGTTGAGGCTCTCAAACGTTATATCACAGAGCCATTCAAGCGTGTTTCTTATGATGATG
CTATTACACTTCTTCAAGAGCATGAAGCAGATGAAGATACAGATTATGAACATTTAGAGCATGGTGATGACTTTGGTTCC
CCACATGAAACTTGGATTTCTAATTACTTTGGAGTACCGACATTTGTAGTGAATTACCCAGCAAGCTTTAAAGCATTTTA
TATGAAACCAGTTCCTGGAAATCCAGAACGCGTTCTTTGTGCTGATCTTTTAGCTCCAGAAGGTTATGGAGAGATCATTG
GCGGCTCAATGCGTGAAGACAACTACGATACTCTTGTGGCTAAAATGGATGAACTAGGTATGGATAAATCAGAATATGAC
TTTTACCTTGACCTTCGTAAATATGGCTCTGTTCCTCATGGCGGTTTTGGTATAGGTATTGAACGTATGGTAACTTTTGT
TGCTGGTACCAAACATATTCGCGAAGCTATTCCATTCCCACGTATGTTACATCGGATTAGACCCTAA

Upstream 100 bases:

>100_bases
GTTATGCTACAGATATCGAAACCCTTAAAGAAGCTGTTCGTAGACTGCATGTCTTTATGGAAAGTAATGAAATTAATTAA
ATAAAAATAGAGAGAAACTT

Downstream 100 bases:

>100_bases
TAATACAAAAAGTTCATGTCATCTATGAACTTTTTGTATTGGTAAGAAGTGAGTGTGTTATAAAAAAATCAATATGTCCT
AAAGGAGAGATAAGAAATAG

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYGEESGHEKFDVIKRLNQETSV
YVTGIVKEDERSKFGYELDITDLEIIGESHEYPITPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGF
IKFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFL
SHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGS
PHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDTLVAKMDELGMDKSEYD
FYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIRP

Sequences:

>Translated_448_residues
MSKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYGEESGHEKFDVIKRLNQETSV
YVTGIVKEDERSKFGYELDITDLEIIGESHEYPITPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGF
IKFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFL
SHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGS
PHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDTLVAKMDELGMDKSEYD
FYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIRP
>Mature_447_residues
SKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYGEESGHEKFDVIKRLNQETSVY
VTGIVKEDERSKFGYELDITDLEIIGESHEYPITPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGFI
KFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFLS
HEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGSP
HETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDTLVAKMDELGMDKSEYDF
YLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIRP

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI226491502, Length=457, Percent_Identity=32.8227571115974, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI4758762, Length=453, Percent_Identity=32.4503311258278, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI45439306, Length=477, Percent_Identity=25.7861635220126, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1787161, Length=473, Percent_Identity=35.3065539112051, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1788173, Length=261, Percent_Identity=24.5210727969349, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71984122, Length=455, Percent_Identity=35.1648351648352, Blast_Score=260, Evalue=9e-70,
Organism=Caenorhabditis elegans, GI17556372, Length=427, Percent_Identity=30.2107728337237, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17551876, Length=477, Percent_Identity=27.0440251572327, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71994340, Length=407, Percent_Identity=22.3587223587224, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535925, Length=407, Percent_Identity=22.3587223587224, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535927, Length=407, Percent_Identity=22.3587223587224, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321807, Length=451, Percent_Identity=34.8115299334812, Blast_Score=245, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319872, Length=463, Percent_Identity=32.829373650108, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6323011, Length=488, Percent_Identity=28.8934426229508, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI19921528, Length=437, Percent_Identity=32.7231121281465, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI19922416, Length=461, Percent_Identity=31.4533622559653, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17136276, Length=338, Percent_Identity=28.9940828402367, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.22 [H]

Molecular weight: Translated: 51262; Mature: 51131

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYG
CCCCEEEEEEHHHHCCCEEEEEEEEECCCCCCCEEEEEEECCCHHHCCCCCCCHHHHHHC
EESGHEKFDVIKRLNQETSVYVTGIVKEDERSKFGYELDITDLEIIGESHEYPITPKEHG
CCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEECCCEEEEECCCCCCCCCCCCCC
TDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGFIKFDSPILSENAAEDSTELF
CCEEECCCCHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCEEEECCCHHCCCCCCCHHHHH
ETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFL
HHCCCCCCCEECCCCCEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
SHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HEADEDTDYEHLEHGDDFGSPHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLC
CCCCCCCCHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
ADLLAPEGYGEIIGGSMREDNYDTLVAKMDELGMDKSEYDFYLDLRKYGSVPHGGFGIGI
HHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCCCCCCCH
ERMVTFVAGTKHIREAIPFPRMLHRIRP
HHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
SKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYG
CCCEEEEEEHHHHCCCEEEEEEEEECCCCCCCEEEEEEECCCHHHCCCCCCCHHHHHHC
EESGHEKFDVIKRLNQETSVYVTGIVKEDERSKFGYELDITDLEIIGESHEYPITPKEHG
CCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEECCCEEEEECCCCCCCCCCCCCC
TDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGFIKFDSPILSENAAEDSTELF
CCEEECCCCHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCEEEECCCHHCCCCCCCHHHHH
ETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFL
HHCCCCCCCEECCCCCEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
SHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HEADEDTDYEHLEHGDDFGSPHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLC
CCCCCCCCHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
ADLLAPEGYGEIIGGSMREDNYDTLVAKMDELGMDKSEYDFYLDLRKYGSVPHGGFGIGI
HHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCCCCCCCH
ERMVTFVAGTKHIREAIPFPRMLHRIRP
HHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA