BacMap

Definition	Streptococcus pyogenes MGAS10750 chromosome, complete genome.
Accession	NC_008024
Length	1,937,111

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The map label for this gene is butA [H]

Identifier: 94993949

GI number: 94993949

Start: 536352

End: 537143

Strand: Direct

Name: butA [H]

Synonym: MGAS10750_Spy0553

Alternate gene names: 94993949

Gene position: 536352-537143 (Clockwise)

Preceding gene: 94993947

Following gene: 94993950

Centisome position: 27.69

GC content: 39.27

Gene sequence:

>792_bases
TTGACTAAAAAATATGAGGTGGAAGATATGTCAAAAGTTGCTATTGTTACTGGTGCTGGTCAAGGAATTGGATTTGCTAT
TGCGAAACGTCTTCATGCAGACGGCTTTAAAATAGGCATTTTAGACTATAATGAAGAGACTGCTCAGGCTGCGGTTGATA
AACTATCACCTGAGGATGCTGTTGCAGTTGTAGCAGATGTTTCAAAACGTGACCAAGTTTTTGATGCTTTCCAAAAAGTT
GTAGATACTTTTGGTGATTTGAATGTTGTTGTTAACAATGCAGGTGTTGCCCCAACAACCCCTCTTGACACGATTACTGA
AGAGCAGTTTGAAAAGGCTTTTGCAATCAATGTCGGAGGAACGATTTGGGGAAGCCAAGCAGCTCAAAAACATTTTAGAG
AATTAGGTCATGGCGGAAAAATTATAAATGCAACATCACAAGCAGGATGTGAAGGGAATCCTAATTTGACTGTTTATGGT
GGTACAAAATTTGCAGTTCGTGGTATTACACAGACTTTGGCAAAGGATTTGGCATCAGAAGGAATCACAGTCAATGCTTA
CGCACCAGGTATTGTTAAAACACCTATGATGTTTGATATTGCCCATGAAGTTGGTAAAAATGCAGGCAAAGATGATGAAT
GGGGTATGGATCAATTTGCAAAAGATATCACTTTGAAACGCTTGTCTGAACCAGAAGATGTTGCTAATGCAGTAGGCTTC
CTAGCGGGAGATGATTCAAATTATATCACTGGACAAACAATAGTTGTCGATGGTGGTATGGTATTCCATTAA

Upstream 100 bases:

>100_bases
CACCGTTTTCATAAAGGTGTATCATAAAGGTAATCAATAAGCCAAGCCTAAAGCTGAACTTAGTTTAAGAACACTGACTT
TTTGAGAGCAACCTAATCGG

Downstream 100 bases:

>100_bases
AAATGATTAATACTGACACTGTGAGTGAAACTCACAGTGTTTTTTATACTTCTTAAAAAATTATCCTATCTTGGTTATTG
GAGTGATGGCACCTTTGAGA

Product: acetoin reductase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTKKYEVEDMSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKV
VDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYG
GTKFAVRGITQTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMDQFAKDITLKRLSEPEDVANAVGF
LAGDDSNYITGQTIVVDGGMVFH

Sequences:

>Translated_263_residues
MTKKYEVEDMSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKV
VDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYG
GTKFAVRGITQTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMDQFAKDITLKRLSEPEDVANAVGF
LAGDDSNYITGQTIVVDGGMVFH
>Mature_262_residues
TKKYEVEDMSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDAVAVVADVSKRDQVFDAFQKVV
DTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGGTIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGG
TKFAVRGITQTLAKDLASEGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMDQFAKDITLKRLSEPEDVANAVGFL
AGDDSNYITGQTIVVDGGMVFH

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=270, Percent_Identity=34.0740740740741, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI32483357, Length=263, Percent_Identity=33.4600760456274, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=33.4661354581673, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI31542939, Length=243, Percent_Identity=34.9794238683128, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=29.7709923664122, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=30.6122448979592, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=31.8725099601594, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=36.1581920903955, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI126723750, Length=266, Percent_Identity=28.9473684210526, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=30.2631578947368, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=28.4615384615385, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=28.1746031746032, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI210032110, Length=195, Percent_Identity=33.8461538461538, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI142976729, Length=190, Percent_Identity=33.1578947368421, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=32.7956989247312, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI66933014, Length=204, Percent_Identity=32.843137254902, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=27.6595744680851, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=30.5263157894737, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI83715985, Length=260, Percent_Identity=26.5384615384615, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4504503, Length=218, Percent_Identity=29.3577981651376, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40807363, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=34.6613545816733, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=31.7829457364341, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=32.1285140562249, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=30.8, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=28.957528957529, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786812, Length=247, Percent_Identity=31.1740890688259, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=30.7086614173228, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=31.1023622047244, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=29.6442687747036, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=28.4, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=28.8537549407115, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=29.2817679558011, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786701, Length=193, Percent_Identity=28.4974093264249, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=35.0393700787402, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=33.8645418326693, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI115534694, Length=264, Percent_Identity=32.9545454545455, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=31.7460317460317, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=32.4, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=33.5907335907336, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=31.8007662835249, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193204405, Length=259, Percent_Identity=32.046332046332, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=32.183908045977, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=32.9501915708812, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=30.1960784313725, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=27.4809160305344, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=31.3207547169811, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=31.1538461538462, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=31.7164179104478, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=31.7829457364341, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=30.8880308880309, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=31.0077519379845, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=31.021897810219, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=28.1368821292776, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=32.8301886792453, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17567345, Length=193, Percent_Identity=31.0880829015544, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=28.957528957529, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=26.953125, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=259, Percent_Identity=27.4131274131274, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=31.203007518797, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508651, Length=260, Percent_Identity=28.8461538461538, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=25.78125, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=30.3664921465969, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=256, Percent_Identity=27.34375, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=32.5396825396825, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=31.4741035856574, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=32.9365079365079, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=29.5275590551181, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=29.9212598425197, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=30.241935483871, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644337, Length=232, Percent_Identity=28.8793103448276, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640492, Length=190, Percent_Identity=35.2631578947368, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281364892, Length=170, Percent_Identity=33.5294117647059, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=30.5882352941176, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737361, Length=261, Percent_Identity=28.735632183908, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281364494, Length=242, Percent_Identity=29.3388429752066, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24665243, Length=259, Percent_Identity=25.0965250965251, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221331218, Length=259, Percent_Identity=25.0965250965251, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=27.1356783919598, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24581726, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24665247, Length=260, Percent_Identity=25.3846153846154, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221331216, Length=260, Percent_Identity=25.3846153846154, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571387, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641232, Length=209, Percent_Identity=27.7511961722488, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161076933, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584748, Length=195, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI116007236, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584744, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574402, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221510726, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641388, Length=202, Percent_Identity=29.7029702970297, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 27931; Mature: 27799

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKYEVEDMSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDA
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCHH
VAVVADVSKRDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGG
EEEEHHCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCC
TIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGITQTLAKDLASE
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHC
GITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMDQFAKDITLKRLSEPEDVANAVGF
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHE
LAGDDSNYITGQTIVVDGGMVFH
EECCCCCEEECEEEEEECCEEEC
>Mature Secondary Structure 
TKKYEVEDMSKVAIVTGAGQGIGFAIAKRLHADGFKIGILDYNEETAQAAVDKLSPEDA
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCHH
VAVVADVSKRDQVFDAFQKVVDTFGDLNVVVNNAGVAPTTPLDTITEEQFEKAFAINVGG
EEEEHHCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCC
TIWGSQAAQKHFRELGHGGKIINATSQAGCEGNPNLTVYGGTKFAVRGITQTLAKDLASE
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHC
GITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMDQFAKDITLKRLSEPEDVANAVGF
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHE
LAGDDSNYITGQTIVVDGGMVFH
EECCCCCEEECEEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA