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The map label for this gene is metK1

Identifier: 94993861

GI number: 94993861

Start: 455437

End: 456636

Strand: Direct

Name: metK1

Synonym: MGAS10750_Spy0465

Alternate gene names: NA

Gene position: 455437-456636 (Clockwise)

Preceding gene: 94993860

Following gene: 94993862

Centisome position: 23.51

GC content: 29.92

Gene sequence:

>1200_bases
ATGGATTTAAAAATTACAAACGGCTTTTATGACCCAAGTCATTTATCATACGAAGTAGTAGAACGCAAAGGCTTAGGTCA
CCCTGATACCTTAGCAGATGGAATTGCTGAGCAAATTGAAATTGATTACTCACTTTATTGTTTGGACAAGTTTGGTGTTA
TTCCACATCATAATTTTGATAAGATTATTATCCGAGGGGGACATTCAGTTCAGGATTTTGGTGGAAGTGACTTTATTGAA
CCAATTAAAATTATTTTTCTAGGTAGGGCGAGCAAAAAATGTTTTAATAGTCCAATTCCACTTTTTAAAATTCAGAAAAA
GGCTGCAACTAAATATTTAAATAGAATTTTACCTAATTTAGATGTTGAAAATTATGTAGAATTTGAGACATTGACCTCAG
ATTTTACTACAAAAACTAATTGGTTCTCGCCTGAAGCAATAGAAGATTTACCGGAGTATCTAGATGTACCAAAGGCAAAT
GATACAGCTACAATGATAAGTTATTGGCCATTAACAATTTCTGAAGAATTAGCATTAATGATTGAAGGGTATTTTTATAA
ATTAGATAAGAATGAATTACCAACGCCAAGATTTACTAAAATGGGTGGTGATATTAAAGTAATGGTCGTAAGGAACGATT
TAGAATATTCTATTAGAATAAATTTTCCTTTAATAAGTAAATTTTTTAACAATGATATTGAAAGTCAGTTGTATGTTGAT
AAACACGTAGAAAAAATTAAGAAATATATTGAACAAAAGTATAAAAACATAAGCTTTTCTATTGATTACCATTATTATTT
AACTACTACAGGTTCTTGTATTGATTTCGGAGAAGAAGGTGCAGTTGGTCGAGGTAATAAAACTCATGGTATCATATCAA
GTTTTAGGCCAAATACTATGGAAGCACCAGCTGGAAAAAATTGTACTTATTTTGTAGGAAAGGTTTGGGGATTTTTGTCT
GATACTATTGCCAAAGAAATTTATGAAGCATTCAATACTCCCTGTCAAATCATTATGCAATTAAATATTGGATCAAAATT
GTATAGACCAACCCATTTATTTATTCAGACAGAAGAAAGTGTTGATCAAGAAAGAGTATTAGAAATTGTTAACAGGCATT
TAAATAATGGTAAACAAAATACTAATTTAATCTTGTCAACTCAACATTTTATCCCTAAAACCAATGTTTATGATGGATAA

Upstream 100 bases:

>100_bases
TATTCCTGAAGATTGCTATATCAATAATGCAATTGAGATAACAAAATTATTAATTAACTTATATTCAGAATGTGAAAAAA
TTTATTTATGAGGTGTAACT

Downstream 100 bases:

>100_bases
AACTGTTTTATATTTTGGGTTGGTTGAAATTTCTTTTGATGTGCCTGACTTTATATTTCAAAAAATAAAAGAGCAGAATA
ATAAAATTAGATATTATAGC

Product: S-adenosylmethionine synthetase

Products: phosphate; diphosphate; S-adenosyl-L-methionine

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIE
PIKIIFLGRASKKCFNSPIPLFKIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTMEAPAGKNCTYFVGKVWGFLS
DTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG

Sequences:

>Translated_399_residues
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIE
PIKIIFLGRASKKCFNSPIPLFKIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTMEAPAGKNCTYFVGKVWGFLS
DTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG
>Mature_399_residues
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFDKIIIRGGHSVQDFGGSDFIE
PIKIIFLGRASKKCFNSPIPLFKIQKKAATKYLNRILPNLDVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKAN
DTATMISYWPLTISEELALMIEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTMEAPAGKNCTYFVGKVWGFLS
DTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEESVDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG

Specific function: Unknown

COG id: COG1812

COG function: function code E; Archaeal S-adenosylmethionine synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AdoMet synthetase 2 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002795
- ProDom:   PD011777 [H]

Pfam domain/function: PF01941 AdoMet_Synthase [H]

EC number: 2.5.1.6

Molecular weight: Translated: 45782; Mature: 45782

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFD
CCEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHEEECEEEEEEECCCCCCCCCCC
KIIIRGGHSVQDFGGSDFIEPIKIIFLGRASKKCFNSPIPLFKIQKKAATKYLNRILPNL
EEEEECCCCCCCCCCCCHHCEEEEEEECCCCHHHHCCCCCCEEEHHHHHHHHHHHHCCCC
DVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKANDTATMISYWPLTISEELALM
CHHHEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHEE
IEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
EEEEEEEECCCCCCCCHHHHCCCCEEEEEEECCCEEEEEECCHHHHHHHCCCCHHHHHHH
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTM
HHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHHCCCCCC
EAPAGKNCTYFVGKVWGFLSDTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEES
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEHHC
VDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG
CCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MDLKITNGFYDPSHLSYEVVERKGLGHPDTLADGIAEQIEIDYSLYCLDKFGVIPHHNFD
CCEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHEEECEEEEEEECCCCCCCCCCC
KIIIRGGHSVQDFGGSDFIEPIKIIFLGRASKKCFNSPIPLFKIQKKAATKYLNRILPNL
EEEEECCCCCCCCCCCCHHCEEEEEEECCCCHHHHCCCCCCEEEHHHHHHHHHHHHCCCC
DVENYVEFETLTSDFTTKTNWFSPEAIEDLPEYLDVPKANDTATMISYWPLTISEELALM
CHHHEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHEE
IEGYFYKLDKNELPTPRFTKMGGDIKVMVVRNDLEYSIRINFPLISKFFNNDIESQLYVD
EEEEEEEECCCCCCCCHHHHCCCCEEEEEEECCCEEEEEECCHHHHHHHCCCCHHHHHHH
KHVEKIKKYIEQKYKNISFSIDYHYYLTTTGSCIDFGEEGAVGRGNKTHGIISSFRPNTM
HHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCEEECCCCCCCCCCCCCCCHHHHCCCCCC
EAPAGKNCTYFVGKVWGFLSDTIAKEIYEAFNTPCQIIMQLNIGSKLYRPTHLFIQTEES
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEHHC
VDQERVLEIVNRHLNNGKQNTNLILSTQHFIPKTNVYDG
CCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-methionine; H2O

Specific reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12122206; 12799345 [H]