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The map label for this gene is aroE [H]

Identifier: 94993857

GI number: 94993857

Start: 451953

End: 452879

Strand: Direct

Name: aroE [H]

Synonym: MGAS10750_Spy0461

Alternate gene names: 94993857

Gene position: 451953-452879 (Clockwise)

Preceding gene: 94993855

Following gene: 94993858

Centisome position: 23.33

GC content: 27.72

Gene sequence:

>927_bases
ATGCTTGTACTTTATGTTAGTAGTAAACTAATTAAACGTAGGAGGATGAAATTTATGTATTCTGCATTGCTTGGTAATCC
AGTTGAACATTCTATATCAGATGAATTATTTGAATATCTAAATCACAACATAGGAGTTCTGGATGAATATAAACATAAAA
AAATTTTGGTAGACTCAGTGTGTTTAGAAGATAAAATCAAACATCTGATAAATGATCCAAAATGTATTGGATTAAATATA
ACTTTACCTTATAAAAGAGAGGTAATGAGGTATATTGACAATTTAGACAGAGTAGCAGAGATAACTGGATCTGTTAACAA
TATTTATAAATCTGGAAATATAATTACAGGAACTAATACTGATTGGAAAGGTATTTATAATACATTAGTTTTCTTTAATA
TTAGCCATATAACAAAATGTTGTGTTTTAGGCACTGGCGGTACTGCTAGAGCTGCTATTTTCACTTTACAAAAACTACAA
ATCTCACCAACAGTTGTATACAGGGAGCCAATTAGTGAGAATACAAGAAGTTTGATAAAGAGTTTCCCTGATTTAAAGTA
TATTACATATAAGGAATTGGCTGATCAACAAATTTTAAATGATATAGAAATCATAATAAATACTACACCAGTTGGTATGA
TAAATTATGAAGAAAGTTTACCTATAAATTTTGATCATTTGGACAATGTTAATTATAAAGATAAATACTTTATGGATGTA
GTTTTCAATCCTTTACATACGAAACTTCATGAATATTTTGGTAAAAAAGGAGCAAAAATAATTGATGGTTTATGGGTTTT
GATTTTTCAGGGAATTGAAGCATTTTCATTGTGGAGTGATAAAATTAATGATGGTAAATATTTTTTTTCAAAAGATGATG
TTGTCCTAATTCATACATTTCTAGAAGGGAAGATAAAAGGAAAATGA

Upstream 100 bases:

>100_bases
CAATGGATATTATCATTATTGTTGGTGGGTAAGTTACTTAGGTGTATACCTAAGTCTTTAGATACTCTAAAGACTTATAG
GTAATGGTTAGCTCTGTGTA

Downstream 100 bases:

>100_bases
CTTTTCATATTACAGTAAATCTTGATGAAATATCAGACAAACTAGATGATTCATTGAAATTTTTAAATAGATTATCAATT
AAAAGTTGTGAATTACGAAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNI
TLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQ
ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDIEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK

Sequences:

>Translated_308_residues
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNI
TLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQ
ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDIEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK
>Mature_308_residues
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNI
TLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQ
ISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQILNDIEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=285, Percent_Identity=27.719298245614, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789675, Length=274, Percent_Identity=24.0875912408759, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320332, Length=273, Percent_Identity=26.3736263736264, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 35477; Mature: 35477

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSV
CEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
CLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNT
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCC
DWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSLIK
CHHHHHHHHHHEEHHHHHHEEEECCCCCHHHHHHHHHHEECCCEEEEECCCCHHHHHHHH
SFPDLKYITYKELADQQILNDIEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
HCCCCEEEHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCHHCCCCCCCCHHHHHHH
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEECCCCEEEEEEE
LEGKIKGK
ECCEECCC
>Mature Secondary Structure
MLVLYVSSKLIKRRRMKFMYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSV
CEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
CLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNT
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCC
DWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSLIK
CHHHHHHHHHHEEHHHHHHEEEECCCCCHHHHHHHHHHEECCCEEEEECCCCHHHHHHHH
SFPDLKYITYKELADQQILNDIEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDV
HCCCCEEEHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCHHCCCCCCCCHHHHHHH
VFNPLHTKLHEYFGKKGAKIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEECCCCEEEEEEE
LEGKIKGK
ECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]