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The map label for this gene is rnr1 [H]

Identifier: 94993823

GI number: 94993823

Start: 416171

End: 418504

Strand: Direct

Name: rnr1 [H]

Synonym: MGAS10750_Spy0427

Alternate gene names: 94993823

Gene position: 416171-418504 (Clockwise)

Preceding gene: 94993822

Following gene: 94993824

Centisome position: 21.48

GC content: 41.6

Gene sequence:

>2334_bases
ATGATGAAAGAAAGAATTATGACTTACCTCAAGGAGCATGGCAAGTCCAATGTGAACGACTTGGCTGCGGCCTTGGAGAT
GGCTGGAGCTAAGCATTTTCCCAGCCTTATTAAAACCATTTCCAAAATGGAAAGTCAGAGCCTTTTACGGTTTTCAGATG
ATGGCAGTCTGGCTCTTAGAAAAGAGCGTGAAAAGAAAAAAGAACCTACTGTTCAGGGTGTTTTTCGTGCCAATAAAGCA
GGCTTTGGTTTCTTACATGTGGATGAGAATGAAGACGATATGTTTATCGGTCGTAATGATGTTGGGTATGCTATTGATGG
TGATACTGTCGAAGTAGTGGTTAAAAAGCCAGCAGACCGTCTCAAAGGCACAGCGGCTGAAGCTAAGGTCGTTGCTATTG
TTGACCGTTCTTTAAAAACAGCTGTTGGAACCTTTATTTTAGATGATGACAAACCAAAATATGCTGGTTATATCAGGTCC
AAAAACCAAAAGATTCAACAAAAAATCTATATCAAAAAAGAACCTGTTGTGCTTAAAGGCACTGAAATCATCAAGGTTGA
TATTGATAAATACCCCACACGCGGGCACGATTATTTTGTAGCCAGTGTGCGTGATATCGTAGGCCATCAAGGAGACGTTG
GAATTGATGTCCTAGAAGTCCTTGAATCGATGGATATCGTGTCAGAATTTCCAGCAGAAGTTTTAGCTGAGGCCAATGCT
ATTTCAGAAGCACCAACTGCTAAAGATTTAATAGGCCGTGTGGATTTGCGTCAAGAAACCACCATTACTATTGATGGTGC
GGACGCCAAAGACTTAGATGATGCTATCCATATTAAGCTATTGGATAACGGGAATTATGAACTTGGGGTACATATTGCGG
ATGTCTCATATTATGTGACAGAAGGATCTGCCCTTGATAAGGAAGCTATCGCCCGTGGCACTTCTGTCTATGTCACCGAT
CGTGTGGTTCCGATGTTACCAGAGCGTTTGTCAAATGGCATCTGCTCTTTGAACCCTAACGTTGATCGTTTGACCCAGTC
AGCCTTGATGGAAATTAATTCTCAAGGGCATGTGGTCAATTATCAAATCTGTCAATCAGTGATTAAGACAACTTACCGAA
TGACGTATAGTACGGTCAATGACATGATTGCAGGAGATGAAGAAGCGCTCCAAGAATTCGCTAGCATTGCTGATGATGTG
ACCCTTATGGTAACCTTACATAGGATCTTGGAAGCTATGCGGTCAAAACGAGGCGCCTTGAATTTTGATACGCAAGAAGC
AAAAATTATTGTCAATGACAAAGGAATGCCGGTTGATGTGGTGCTTCGTCAAAGGGGCATTGCAGAGCGGATGATTGAAT
CCTTTATGCTAGCAGCCAATGAGTGTGTGGCAGAACATTTTGCAAAAGCTAAGTTACCGTTTATCTACCGTATTCACGAA
GAACCAAAGGTTGAAAAACTTCAACAATTTATTGATTACGCTAGCACCTTTGGTATTCACATTCAAGGAACAGCCAACAA
GATTTCTCAGGAAGCCTTGCAAGCCTTTATGGCAAAAGTCGAAGGTCAACCAGGAGCAGAAGTGCTCAACATGATGCTTC
TACGCTCTATGCAACAGGCAAGATATTCAGAACATAATCATGGCCATTACGGTTTGGCCGCAGAATATTACACTCACTTT
ACCAGTCCGATTCGTCGTTACCCTGACTTATTGGTTCACCGCATGGTTCGTGAGTACAATCAACCTAGTCAAGAAAAGCG
CGACCATTTTGCTCAGATCATTCCAGAGCTGGCAACATCTTCTTCACAGTTAGAGCGTCGTGCTATTGATGCTGAACGCG
TGGTGGAAGCCATGAAAAAAGCTGAGTATATGGCAGAGTATGTGGGTGAAGAATTTGACGGTATCGTGGCCAGTGTCGTT
AAATTTGGTTTTTTTGTAGAATTGCCAAATACGATTGAAGGTTTGGTTCATATCACTAGCTTACCGGAATACTATCACTT
TAATGAAAGAACGCTAAGCCTTCAAGGTGAAAAATCAGGTAAGGTCTTTAAGGTCGGTCAACCTATTCGTGTGAAATTGG
TTAAGGCTGACAAGGAAACTGGTGACATTGACTTTGAGTATTTACCTAGCGACTTTGATGTGGTTGAAAAAATCAAGATG
TCGGATAAAGCTAGTCGACGAGATCGCCGTAAATCCTCAAAATCATCTAAAGGGACAAAGAAAAAAGAACCTAAAGAAGT
AGCCAAGGCAAAAACCAAGGGTAAAACTAAAAAAGGGTCTAAAAAACCATTTTACAAAGAACAAGCAAAAAAGAAGAGTC
GTAAAAGGAGTTAA

Upstream 100 bases:

>100_bases
TAAATAAGGAGTGAGCTTGACAGAGTTAGTCTAGCTCATTTTTTTATCAGCGAAACGGATTGATATCCTCCAACAAACAA
AACAGAAATAGAAATTAGGT

Downstream 100 bases:

>100_bases
CTATGGCAAAAGGTGAAGGTCATATACTGGCGCAAAATAAAAAGGCTAGACATGATTATCACATTGTTGAAACCGTTGAA
GCAGGGATTGTCTTAACGGG

Product: exoribonuclease II

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 777; Mature: 777

Protein sequence:

>777_residues
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKA
GFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPTRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTD
RVVPMLPERLSNGICSLNPNVDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVTLHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
EPKVEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHF
TSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVASVV
KFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS

Sequences:

>Translated_777_residues
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKA
GFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPTRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTD
RVVPMLPERLSNGICSLNPNVDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVTLHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
EPKVEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHF
TSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVASVV
KFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS
>Mature_777_residues
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKA
GFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPTRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTD
RVVPMLPERLSNGICSLNPNVDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVTLHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
EPKVEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHF
TSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVASVV
KFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=471, Percent_Identity=30.9978768577495, Blast_Score=206, Evalue=8e-53,
Organism=Homo sapiens, GI190014625, Length=471, Percent_Identity=30.9978768577495, Blast_Score=206, Evalue=8e-53,
Organism=Homo sapiens, GI134288890, Length=394, Percent_Identity=32.2335025380711, Blast_Score=203, Evalue=6e-52,
Organism=Homo sapiens, GI219521928, Length=407, Percent_Identity=28.992628992629, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI19115966, Length=422, Percent_Identity=29.3838862559242, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI156105695, Length=342, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI156105693, Length=150, Percent_Identity=32, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87082383, Length=722, Percent_Identity=32.409972299169, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1787542, Length=681, Percent_Identity=26.1380323054332, Blast_Score=168, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=31.5403422982885, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=472, Percent_Identity=29.8728813559322, Blast_Score=180, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324552, Length=604, Percent_Identity=30.1324503311258, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320499, Length=319, Percent_Identity=26.6457680250784, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323943, Length=429, Percent_Identity=20.979020979021, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24649634, Length=564, Percent_Identity=30.3191489361702, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI19922976, Length=378, Percent_Identity=32.010582010582, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24654597, Length=378, Percent_Identity=32.010582010582, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24654592, Length=399, Percent_Identity=31.5789473684211, Blast_Score=172, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 87345; Mature: 87345

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALR
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCEEHH
KEREKKKEPTVQGVFRANKAGFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADR
HHHHHHCCCCHHHHHHCCCCCCEEEEECCCCCCEEECCCCCCEEECCCEEEEEEECCHHH
LKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRSKNQKIQQKIYIKKEPVVLKG
HCCCHHHCEEEEEHHHHHHHHHCEEEECCCCCCHHHHHHCCCHHHHHHHEEECCCEEEEC
TEIIKVDIDKYPTRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
CEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHH
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVT
HCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCEEEEEEEEEEEEEEE
EGSALDKEAIARGTSVYVTDRVVPMLPERLSNGICSLNPNVDRLTQSALMEINSQGHVVN
CCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEE
YQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDVTLMVTLHRILEAMRSKRGAL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
NFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
CCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EPKVEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQA
CCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RYSEHNHGHYGLAAEYYTHFTSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
SSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVASVVKFGFFVELPNTIEGLVHITS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCHHHHHHHHHHC
LPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
CCHHHCCCCEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALR
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCEEHH
KEREKKKEPTVQGVFRANKAGFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADR
HHHHHHCCCCHHHHHHCCCCCCEEEEECCCCCCEEECCCCCCEEECCCEEEEEEECCHHH
LKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRSKNQKIQQKIYIKKEPVVLKG
HCCCHHHCEEEEEHHHHHHHHHCEEEECCCCCCHHHHHHCCCHHHHHHHEEECCCEEEEC
TEIIKVDIDKYPTRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
CEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHH
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVT
HCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCEEEEEEEEEEEEEEE
EGSALDKEAIARGTSVYVTDRVVPMLPERLSNGICSLNPNVDRLTQSALMEINSQGHVVN
CCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEE
YQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDVTLMVTLHRILEAMRSKRGAL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
NFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
CCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EPKVEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQA
CCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RYSEHNHGHYGLAAEYYTHFTSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
SSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVASVVKFGFFVELPNTIEGLVHITS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCHHHHHHHHHHC
LPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
CCHHHCCCCEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]