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The map label for this gene is coaE [H]

Identifier: 94993818

GI number: 94993818

Start: 412025

End: 412645

Strand: Direct

Name: coaE [H]

Synonym: MGAS10750_Spy0422

Alternate gene names: 94993818

Gene position: 412025-412645 (Clockwise)

Preceding gene: 94993817

Following gene: 94993819

Centisome position: 21.27

GC content: 41.55

Gene sequence:

>621_bases
TTGTCCAAAATGCCAGAAAAAAAGACCATGATTATTGGCATCACAGGAGGCATTGCATCAGGAAAATCGACTGTGGTTAA
GGTCATTAGAAAAGCTGGTTATCAGGTGATTGATGCGGATCAAGTGGTCCATGACTTGCAAGAAAAAGGCGGTCGCCTTT
ACGAGGCTCTTAGAGAAGCTTTTGGGAATCAGATTTTAAAAGCAGATGGTGAGTTAGATCGCACAAAGCTGTCAGAAATG
CTTTTTTCAAACCCAGATAATATGGCAACATCCTCAGCCATTCAAAATCAAATCATTAAGGAAGAATTGGCGGCTAAGCG
TGACCACTTAGCACAGAGCCAAGCCATTTTTTTCATGGATATTCCCCTTTTAATGGAATTGGGCTACCAAGACTGGTTTG
ATGCGATTTGGCTGGTTTATGTAGATGCTCAGACACAATTGCAGCGCTTAATGGCTAGAAATCGTTTAGACAAAGGAAAA
GCAAGGCAGCGAATAGCCAGTCAGTTACCAATAGAGGAAAAAAAGCCCTATGCCAGTCTAGTGATTGATAATAATGGAGA
CATGGAAACGTTAATAAAGCAAGTACAATCTGCGTTGTTGTCATTAGCCAATCCGAGGTAG

Upstream 100 bases:

>100_bases
TGCAGGACTATTTGCAGGTTTATGGTCAAACTGGGAAACCGTGTCCTCGTTGTGGACAGGCTATTGTCAAATTAAAAGTT
GGAGGAAGGGGGACGCACAT

Downstream 100 bases:

>100_bases
CTAAGCTGAGAGATTCGTATCATAGCTGTCAAAATCAAGCTATTTCTGTCTAAAACTAGCTGGTCCCTTTTAAATTAGCG
CATCAAGGGTTATATGTTAT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSKMPEKKTMIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKADGELDRTKLSEM
LFSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGK
ARQRIASQLPIEEKKPYASLVIDNNGDMETLIKQVQSALLSLANPR

Sequences:

>Translated_206_residues
MSKMPEKKTMIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKADGELDRTKLSEM
LFSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGK
ARQRIASQLPIEEKKPYASLVIDNNGDMETLIKQVQSALLSLANPR
>Mature_205_residues
SKMPEKKTMIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKADGELDRTKLSEML
FSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKA
RQRIASQLPIEEKKPYASLVIDNNGDMETLIKQVQSALLSLANPR

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=188, Percent_Identity=34.5744680851064, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI191252795, Length=188, Percent_Identity=34.5744680851064, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI205277394, Length=168, Percent_Identity=29.7619047619048, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI110227605, Length=168, Percent_Identity=29.7619047619048, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI110227603, Length=168, Percent_Identity=29.7619047619048, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI110227601, Length=168, Percent_Identity=29.7619047619048, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI110227607, Length=197, Percent_Identity=27.4111675126904, Blast_Score=85, Evalue=4e-17,
Organism=Escherichia coli, GI1786292, Length=185, Percent_Identity=32.972972972973, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17554944, Length=200, Percent_Identity=35.5, Blast_Score=129, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI25143409, Length=168, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320402, Length=196, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644728, Length=201, Percent_Identity=35.3233830845771, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24658602, Length=195, Percent_Identity=31.2820512820513, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 23136; Mature: 23005

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMPEKKTMIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREA
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHCCCHHHHHHHHH
FGNQILKADGELDRTKLSEMLFSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMD
HCCHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEH
IPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQLPIEEKKPYASL
HHHHHHHCHHHHHHHHHHHEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEE
VIDNNGDMETLIKQVQSALLSLANPR
EEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKMPEKKTMIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREA
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHCCCHHHHHHHHH
FGNQILKADGELDRTKLSEMLFSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMD
HCCHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEH
IPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQLPIEEKKPYASL
HHHHHHHCHHHHHHHHHHHEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEE
VIDNNGDMETLIKQVQSALLSLANPR
EEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]