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The map label for this gene is fpg [H]

Identifier: 94993817

GI number: 94993817

Start: 411228

End: 412055

Strand: Direct

Name: fpg [H]

Synonym: MGAS10750_Spy0421

Alternate gene names: 94993817

Gene position: 411228-412055 (Clockwise)

Preceding gene: 94993816

Following gene: 94993818

Centisome position: 21.23

GC content: 42.75

Gene sequence:

>828_bases
ATGCCAGAATTACCAGAAGTTGAAACGGTCCGACGAGGGCTTGAGGCTTTAGTGCTTGGCCAAGAAATTGTGGCTGTTAC
GCTTAAAGTGCCAAAAATGGTTAAAACCGACTTAGAGACGTTTGCCCTGACCCTACCTGGTCAAATCATTCAGTCAGTTG
GCCGTCGGGGAAAATATTTATTAATTGATTTGGGGCAATTAGTGTTGGTATCACATTTGCGGATGGAAGGCAAATATTTG
CTTTTTCCAGATGAGGTCCCTGATAACAAACACTTTCATGTCTTTTTTGAATTGAAAAATGGTTCGACCTTGGTTTACCA
AGATGTGCGTAAATTTGGAACCTTTGATTTGATAGCAAAATCTCAATTATCAGCGTTTTTTGCCAAACGAAAACTAGGCC
CTGAACCAAAGAAAGAGACCTTTAAGTTAAAAACCTTTGAGACTGCTCTGCTATCCTCCCAAAAACCCATAAAACCACAT
CTGTTAGACCAGACCTTGGTTGCTGGTTTAGGGAATATTTATGTGGACGAGGTACTTTGGGCTGCTAAGGTTCATCCAGA
AACTGCGTCTTCTAGGTTGAATAAGGCGGAGATAAAACGGCTGCATGATGAAACCATACGAATCCTAGCTTTAGGAATTG
AAAAGGGCGGTTCGACCGTCCGTACTTACCGTAATGCTTTGGGAGCTGATGGCACCATGCAGGACTATTTGCAGGTTTAT
GGTCAAACTGGGAAACCGTGTCCTCGTTGTGGACAGGCTATTGTCAAATTAAAAGTTGGAGGAAGGGGGACGCACATTTG
TCCAAAATGCCAGAAAAAAAGACCATGA

Upstream 100 bases:

>100_bases
GCAGTCAGTATCCTAGACCTGAGTCTATTGAGTGACTTTTTTATGCTGAGTTTATTCTTTGTAGCAGCAAAGGGTCTAGC
TGTCCTTTAAATAACGGATT

Downstream 100 bases:

>100_bases
TTATTGGCATCACAGGAGGCATTGCATCAGGAAAATCGACTGTGGTTAAGGTCATTAGAAAAGCTGGTTATCAGGTGATT
GATGCGGATCAAGTGGTCCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPELPEVETVRRGLEALVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYL
LFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFETALLSSQKPIKPH
LLDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP

Sequences:

>Translated_275_residues
MPELPEVETVRRGLEALVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYL
LFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFETALLSSQKPIKPH
LLDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP
>Mature_274_residues
PELPEVETVRRGLEALVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYLL
FPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFETALLSSQKPIKPHL
LDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVYG
QTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=272, Percent_Identity=37.5, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1786932, Length=277, Percent_Identity=25.2707581227437, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30686; Mature: 30555

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLEALVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYL
CCCCCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHEEECCHHHHHHHCCCCCEE
LIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAK
EEEHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEECCCCEEHHHHHHHCCCHHHHHH
SQLSAFFAKRKLGPEPKKETFKLKTFETALLSSQKPIKPHLLDQTLVAGLGNIYVDEVLW
HHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
HHHCCCHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHH
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP
CCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLEALVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYL
CCCCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHEEECCHHHHHHHCCCCCEE
LIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAK
EEEHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEECCCCEEHHHHHHHCCCHHHHHH
SQLSAFFAKRKLGPEPKKETFKLKTFETALLSSQKPIKPHLLDQTLVAGLGNIYVDEVLW
HHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
HHHCCCHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHH
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP
CCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]