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The map label for this gene is msrA2 [H]

Identifier: 94993777

GI number: 94993777

Start: 383149

End: 383619

Strand: Direct

Name: msrA2 [H]

Synonym: MGAS10750_Spy0381

Alternate gene names: 94993777

Gene position: 383149-383619 (Clockwise)

Preceding gene: 94993776

Following gene: 94993778

Centisome position: 19.78

GC content: 42.46

Gene sequence:

>471_bases
ATGGTGCAACCTTTTGAGGAGCAAGCAGGTATTTTGTCAGTCAGAAGTGGCTACACAGGTGGGCATCTCCCAAATCCTAG
CTATGAACAAGTTTGTGCCAAAACAACAGGACATACAGAAGCTGTTGAAATTATTTTTGACCCTGAAGAGATCAGCTATA
AGGAATTAGTTGAATTGTATTGGGCGCACACGGATCCAACAGATGCCTTTGGGCAATTTGAAGATCGTGGGGACAACTAC
CGTCCTGTCATTTACTATACAACGGAAAGACAAAAAGAAATTGCAGAGCAATCAAAAGCAAACTTGCAAGCTTCAGGACG
TTTTGACCAACCCATTGTCACCACTATTGAACCAGCAGAGCCATTTTATCTCGCAGAGGATTATCACCAAGGTTTCTATA
AAAAGAATCCCAAGCGGTATGCACAAAGCAGTGCTATTCGTCATCAGTTTTTAGAGGAGAACTGGTCATGA

Upstream 100 bases:

>100_bases
CCACTGGCAAAGTTTTTTGTTACAATGAAGACCATTAAGTGAAGAAAAAGGGGATATAGAGAATGGAAAGAGCCTTTTTG
CAGGAGGTTGTTTCTGGTGT

Downstream 100 bases:

>100_bases
GAAAATCATTTTACAGCTGGCTGATGACACAACGTAACCCTAAATCAAATGAACCTGTGGCGATTTTAGCAGATTTGGTG
TTTGATGACACCACTTTTCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWAHTDPTDAFGQFEDRGDNY
RPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS

Sequences:

>Translated_156_residues
MVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWAHTDPTDAFGQFEDRGDNY
RPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
>Mature_156_residues
MVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWAHTDPTDAFGQFEDRGDNY
RPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=134, Percent_Identity=41.7910447761194, Blast_Score=116, Evalue=8e-27,
Organism=Homo sapiens, GI208609995, Length=134, Percent_Identity=41.7910447761194, Blast_Score=116, Evalue=9e-27,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=42.5925925925926, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1790665, Length=136, Percent_Identity=43.3823529411765, Blast_Score=115, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=129, Percent_Identity=37.2093023255814, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=137, Percent_Identity=29.9270072992701, Blast_Score=72, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=34.2465753424658, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553131, Length=146, Percent_Identity=34.2465753424658, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=33.5616438356164, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18020; Mature: 18020

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELY
CCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
WAHTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAE
HCCCCCCHHHCCHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEECCCCCCCEEEEECCCC
PFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
CEEEHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELY
CCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
WAHTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAE
HCCCCCCHHHCCHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEECCCCCCCEEEEECCCC
PFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
CEEEHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]