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The map label for this gene is panE [H]

Identifier: 94314689

GI number: 94314689

Start: 2530318

End: 2531241

Strand: Reverse

Name: panE [H]

Synonym: Rmet_5770

Alternate gene names: 94314689

Gene position: 2531241-2530318 (Counterclockwise)

Preceding gene: 291481606

Following gene: 94314688

Centisome position: 98.11

GC content: 66.77

Gene sequence:

>924_bases
ATGCGAATTCTGGTTGTCGGAGTGGGAGCCACGGGTGGCTACTTTGGCGCGCGGCTGCTGCAGGCCGGGCGTGATGTGAC
GTTCCTGGTGCGCCCCCGCCGCGCCGCGCAACTGGCCGAACACGGCCTGCGAGTTAAGAGCCCGCACGGCGACCTGCATT
TCCCGAATCCCCCTGTGGTGTTGTCCGAGCAGATCACGCAGCCTTATGACGTGGTGTTGCTGAGCTGCAAGGCGTACGAC
CTCGAAAGCGCCATGGATGGCTTCGCGCCCGCCATGGGGCCGAACACGGTCATCATCCCGTTGCTCAACGGCATGCAGCA
TCTGGATCGCCTCGATGCGCGTTTCGGCGCCGGGCGTGTCATGGGGGGCCGCTGCCTGATCTCCAGCACGCTCGATGACC
AGGGCACCATTCTTCATCTGTCGAGCTTCCACGTTCTGTCGTTTGGCGAGCGCCCTTCGGGCAGCAGTGAGCGCGCGCTG
GCCTTGGCCGCCGCTTTCAGCGATGCCGGCTTCGACGTCCAACGCAGCGACGCCATGCTGCAGGACATGTGGGAGAAATG
GCTGTTCCTTGCCACGCTGGCATCGGCTACCTGCCTGATGCGAGCGACCATCGGCGATATTCTCGCCGCGCCACGCGGGC
GCGAGACCATCGCGGCGTTGCTTGGCGAATGCGCCGGCGTTGCGGCCGCCAATGGCTATCCGGCCCGGGGCCCCGTACTG
GAGCAGGCGAAGACCACGCTGTTTGCCGAAGGATCGCCGCTGACGGCCTCGATGCTGCGCGACCTAGAGCGCGGCGGGGC
GATCGAATCGGACCAGATCGTGGGTGACATGCTGGCCCGCCGTGGCCAGACCGCAGCGCCCACGCTGGAGATGGCGCTGA
CCAGCCTGAAAGCCTACGAAGCGCGCCGCGCGCGCGGAGGCTGA

Upstream 100 bases:

>100_bases
CCATTCGGCGACCGGCATTTCGCTTCCAGCAGACTTTCCAGGCCATCACTACAATGGCGCATTGCCCGGCTCGTTGCCGG
GCCAGATCTGGGAGTGGAGG

Downstream 100 bases:

>100_bases
AGCCGCTGGCGTCCGATTCGCCCGCATCGCAGAATTTGTCAGGACAGAATCAAGCCTGATACACGCGATTTCGATTGGGC
GAACGACGCCGTTTACCTAC

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRILVVGVGATGGYFGARLLQAGRDVTFLVRPRRAAQLAEHGLRVKSPHGDLHFPNPPVVLSEQITQPYDVVLLSCKAYD
LESAMDGFAPAMGPNTVIIPLLNGMQHLDRLDARFGAGRVMGGRCLISSTLDDQGTILHLSSFHVLSFGERPSGSSERAL
ALAAAFSDAGFDVQRSDAMLQDMWEKWLFLATLASATCLMRATIGDILAAPRGRETIAALLGECAGVAAANGYPARGPVL
EQAKTTLFAEGSPLTASMLRDLERGGAIESDQIVGDMLARRGQTAAPTLEMALTSLKAYEARRARGG

Sequences:

>Translated_307_residues
MRILVVGVGATGGYFGARLLQAGRDVTFLVRPRRAAQLAEHGLRVKSPHGDLHFPNPPVVLSEQITQPYDVVLLSCKAYD
LESAMDGFAPAMGPNTVIIPLLNGMQHLDRLDARFGAGRVMGGRCLISSTLDDQGTILHLSSFHVLSFGERPSGSSERAL
ALAAAFSDAGFDVQRSDAMLQDMWEKWLFLATLASATCLMRATIGDILAAPRGRETIAALLGECAGVAAANGYPARGPVL
EQAKTTLFAEGSPLTASMLRDLERGGAIESDQIVGDMLARRGQTAAPTLEMALTSLKAYEARRARGG
>Mature_307_residues
MRILVVGVGATGGYFGARLLQAGRDVTFLVRPRRAAQLAEHGLRVKSPHGDLHFPNPPVVLSEQITQPYDVVLLSCKAYD
LESAMDGFAPAMGPNTVIIPLLNGMQHLDRLDARFGAGRVMGGRCLISSTLDDQGTILHLSSFHVLSFGERPSGSSERAL
ALAAAFSDAGFDVQRSDAMLQDMWEKWLFLATLASATCLMRATIGDILAAPRGRETIAALLGECAGVAAANGYPARGPVL
EQAKTTLFAEGSPLTASMLRDLERGGAIESDQIVGDMLARRGQTAAPTLEMALTSLKAYEARRARGG

Specific function: Unknown

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 32634; Mature: 32634

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGVGATGGYFGARLLQAGRDVTFLVRPRRAAQLAEHGLRVKSPHGDLHFPNPPVV
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCEEECCCCCCCCCCCCEE
LSEQITQPYDVVLLSCKAYDLESAMDGFAPAMGPNTVIIPLLNGMQHLDRLDARFGAGRV
ECHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCE
MGGRCLISSTLDDQGTILHLSSFHVLSFGERPSGSSERALALAAAFSDAGFDVQRSDAML
ECCEEEEECCCCCCCCEEEEECEEEEECCCCCCCCCCHHEEEEEHHCCCCCCCHHHHHHH
QDMWEKWLFLATLASATCLMRATIGDILAAPRGRETIAALLGECAGVAAANGYPARGPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHCCCCCCCCCCHH
EQAKTTLFAEGSPLTASMLRDLERGGAIESDQIVGDMLARRGQTAAPTLEMALTSLKAYE
HHHHHEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARRARGG
HHHCCCC
>Mature Secondary Structure
MRILVVGVGATGGYFGARLLQAGRDVTFLVRPRRAAQLAEHGLRVKSPHGDLHFPNPPVV
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCEEECCCCCCCCCCCCEE
LSEQITQPYDVVLLSCKAYDLESAMDGFAPAMGPNTVIIPLLNGMQHLDRLDARFGAGRV
ECHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCE
MGGRCLISSTLDDQGTILHLSSFHVLSFGERPSGSSERALALAAAFSDAGFDVQRSDAML
ECCEEEEECCCCCCCCEEEEECEEEEECCCCCCCCCCHHEEEEEHHCCCCCCCHHHHHHH
QDMWEKWLFLATLASATCLMRATIGDILAAPRGRETIAALLGECAGVAAANGYPARGPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHCCCCCCCCCCHH
EQAKTTLFAEGSPLTASMLRDLERGGAIESDQIVGDMLARRGQTAAPTLEMALTSLKAYE
HHHHHEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARRARGG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]