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The map label for this gene is yegE [H]

Identifier: 94314670

GI number: 94314670

Start: 2511748

End: 2513736

Strand: Direct

Name: yegE [H]

Synonym: Rmet_5751

Alternate gene names: 94314670

Gene position: 2511748-2513736 (Clockwise)

Preceding gene: 94314668

Following gene: 94314672

Centisome position: 97.35

GC content: 64.61

Gene sequence:

>1989_bases
ATGCCCCGGTTACTGCCGTCGCTCAAGGTACGCATTGCGCTGATCACCACGGTGCTTGCCGGCATTCTCGGCGGAGGCAT
CGTCATCGGCTCGCTCTACTTCGCCCATCTCGATCTCGAAGACGCGCTGCAGAATCAGCAGGACTCCATCGTCAAGCTAT
CGGTGGACCAGCTCGACACGGCGATGGATGACCGTATCGAGCTGCTCTCCCACCTGGCACCGCAACTGCGCGACACGCTC
GCTTCCGCGCATGAGCAGCCACACGATGCCGTACGGGCGGCGCTACAGCAGGCAATCGACCGCACGATACCAATGCCCGA
GGCGTTCAATGCCGTGATGGTCGTCGACGCGGCTGGCACAGTCCTGACCATGGACGGCAAGCCCGTCGAGGTGGGTGACC
GCGCCTACTTCCTCGAGGCCATTCGCACGCGCAATGTCGTGGTTGCCGCGCCGATCCGCTCCCGCGTCGGCGGCTATGTG
GGCGTCCTGGTGGCGGTACCGGTGCTCTCGTTGTCCGGCGAGTTCCTGGGCGTCGCGGGGGGCTGGCTCAACCTTGCCAA
CTCGAACTTCCTGGTGGAAATCGCCAATAACCGGCTGGGCACCACGGGCTTCTACTGCCTGGTGTCGGCCGGCAGCGAAC
CCGTCTATGTCCAGCATCCGGACCCCACCATGGCGCGCAAGCCCGCCCACGCCGTTGGCGAGACCTGCGGCGTGGACGAT
CACAGCGCGCCGCTGGAATTTCTCACCCCGACCCGGCCCGTGATCGCCCGCCGGCTGATGGCAAGCACGGGCTGGGAACT
CGTGGCCGTGATGCCGGCACAGGAAGCCTATGCGCCACTGCGCCAGATGCAGCGTCGATTCCTGATGATGTCGGCCATCG
CCCTGTCGGTGGTGGCGCTGCTGATCTGGCTGGCGGTACGCCAGTTGCTGACGCCGCTTTCTCGCCTGCATCAGGTGGTG
CAGGCGAGCGCGAACGACCTGGATGCATTTCAGCGCTTGCCAAAGCGTCCGCACCGCGACGAGATCGGCGATGTCACCGG
CGCCTTCATCCGCCTGATGCGTGACATGCGCCAGCGCGGACTGCAACTGGCACGCAGCGAACGGCGGCTGCGCGCGGTCA
CCGACACGCTCCCGGCACTGCTGGCCTTCATCGACAGCGACGAACGCTACGTCTTCAACAACATCGCCTACGAGCGTGTG
TTCGGTATGTCGCTGGATGAAATCCAGGGCAAGACCGTGCGCGAAGTGCTGGGCGAGGAACGATACGCACGCGCCCAGCC
CTTCCTGCAACGCGCGCTGCGGGGCGAGGAGGTCAGCTTCGAGGCCGAGTATCACTTCCCGCATCATCACTGGATGGAAA
TGAACTATCGCCCGGAATGGGGCGAGGATGGCCGGCAGGTGGTGGGCGTACACATCCACGTGGAGGACATCACGCGGCGC
AAGGTGGAGAATCTGCGGCTGTCGCACATCTCGCGAACGGACCACCTGACCCAACTCCAGAACCGCAACGCCTTCGAAAG
CCAGTTGCGGGACGCGATGATGCTGAGCCGCGCCGAGCAGCAACTGATGGCCCTGCTTTATCTGGACATGGATCGCTTCA
AGGCCGTCAACGACATACACGGCCATGCCACCGGCGATCTGCTGCTGCAGGCATTCGCGCTGCGTCTGCGGCGCTGTGTG
CGCGAGAGCGATCATGTCGCGCGCATCGGCGGGGACGAATTCGCGGTAATTCTCGAGGACATCGGCACGCCAGCCACGGC
GCAGCGAATTGCCGGCGCGATCCTGGAATCGGTCGGTCGGCACTTCTATTTCGATGGAATACTGGCCGACGTCGACGTGA
GCATCGGCGTGACTCTCTACAAGGGCACGCCGATCAGCGAGGAAACGCTGATGCGGCAGGCCGATGTACTGCTGTATCGC
GCCAAGGCACTGGGCCGGGGTCGCTACGAAATCGGCCCCGCGGAACTGCTGGCAGACGCTGGGGCCTGA

Upstream 100 bases:

>100_bases
AACGTGATAACTTACGTTCGCCAGCAACCAGATCTGCGCAAAGCGCTGGCTCCAGCGAATTCACAGGCTTTCGATGCCAC
ATCGACTCCGTGACACTCAC

Downstream 100 bases:

>100_bases
CCCACTTTCGGCGCTGAAAGCCGCCTGACAGTGTCAGAATCGGCTGGCCGGTGGCGCCAGAGCTGGAGCTGGAGCTGCTG
CTCAGTGCTTCGTGGACTCG

Product: diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MPRLLPSLKVRIALITTVLAGILGGGIVIGSLYFAHLDLEDALQNQQDSIVKLSVDQLDTAMDDRIELLSHLAPQLRDTL
ASAHEQPHDAVRAALQQAIDRTIPMPEAFNAVMVVDAAGTVLTMDGKPVEVGDRAYFLEAIRTRNVVVAAPIRSRVGGYV
GVLVAVPVLSLSGEFLGVAGGWLNLANSNFLVEIANNRLGTTGFYCLVSAGSEPVYVQHPDPTMARKPAHAVGETCGVDD
HSAPLEFLTPTRPVIARRLMASTGWELVAVMPAQEAYAPLRQMQRRFLMMSAIALSVVALLIWLAVRQLLTPLSRLHQVV
QASANDLDAFQRLPKRPHRDEIGDVTGAFIRLMRDMRQRGLQLARSERRLRAVTDTLPALLAFIDSDERYVFNNIAYERV
FGMSLDEIQGKTVREVLGEERYARAQPFLQRALRGEEVSFEAEYHFPHHHWMEMNYRPEWGEDGRQVVGVHIHVEDITRR
KVENLRLSHISRTDHLTQLQNRNAFESQLRDAMMLSRAEQQLMALLYLDMDRFKAVNDIHGHATGDLLLQAFALRLRRCV
RESDHVARIGGDEFAVILEDIGTPATAQRIAGAILESVGRHFYFDGILADVDVSIGVTLYKGTPISEETLMRQADVLLYR
AKALGRGRYEIGPAELLADAGA

Sequences:

>Translated_662_residues
MPRLLPSLKVRIALITTVLAGILGGGIVIGSLYFAHLDLEDALQNQQDSIVKLSVDQLDTAMDDRIELLSHLAPQLRDTL
ASAHEQPHDAVRAALQQAIDRTIPMPEAFNAVMVVDAAGTVLTMDGKPVEVGDRAYFLEAIRTRNVVVAAPIRSRVGGYV
GVLVAVPVLSLSGEFLGVAGGWLNLANSNFLVEIANNRLGTTGFYCLVSAGSEPVYVQHPDPTMARKPAHAVGETCGVDD
HSAPLEFLTPTRPVIARRLMASTGWELVAVMPAQEAYAPLRQMQRRFLMMSAIALSVVALLIWLAVRQLLTPLSRLHQVV
QASANDLDAFQRLPKRPHRDEIGDVTGAFIRLMRDMRQRGLQLARSERRLRAVTDTLPALLAFIDSDERYVFNNIAYERV
FGMSLDEIQGKTVREVLGEERYARAQPFLQRALRGEEVSFEAEYHFPHHHWMEMNYRPEWGEDGRQVVGVHIHVEDITRR
KVENLRLSHISRTDHLTQLQNRNAFESQLRDAMMLSRAEQQLMALLYLDMDRFKAVNDIHGHATGDLLLQAFALRLRRCV
RESDHVARIGGDEFAVILEDIGTPATAQRIAGAILESVGRHFYFDGILADVDVSIGVTLYKGTPISEETLMRQADVLLYR
AKALGRGRYEIGPAELLADAGA
>Mature_661_residues
PRLLPSLKVRIALITTVLAGILGGGIVIGSLYFAHLDLEDALQNQQDSIVKLSVDQLDTAMDDRIELLSHLAPQLRDTLA
SAHEQPHDAVRAALQQAIDRTIPMPEAFNAVMVVDAAGTVLTMDGKPVEVGDRAYFLEAIRTRNVVVAAPIRSRVGGYVG
VLVAVPVLSLSGEFLGVAGGWLNLANSNFLVEIANNRLGTTGFYCLVSAGSEPVYVQHPDPTMARKPAHAVGETCGVDDH
SAPLEFLTPTRPVIARRLMASTGWELVAVMPAQEAYAPLRQMQRRFLMMSAIALSVVALLIWLAVRQLLTPLSRLHQVVQ
ASANDLDAFQRLPKRPHRDEIGDVTGAFIRLMRDMRQRGLQLARSERRLRAVTDTLPALLAFIDSDERYVFNNIAYERVF
GMSLDEIQGKTVREVLGEERYARAQPFLQRALRGEEVSFEAEYHFPHHHWMEMNYRPEWGEDGRQVVGVHIHVEDITRRK
VENLRLSHISRTDHLTQLQNRNAFESQLRDAMMLSRAEQQLMALLYLDMDRFKAVNDIHGHATGDLLLQAFALRLRRCVR
ESDHVARIGGDEFAVILEDIGTPATAQRIAGAILESVGRHFYFDGILADVDVSIGVTLYKGTPISEETLMRQADVLLYRA
KALGRGRYEIGPAELLADAGA

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=306, Percent_Identity=30.3921568627451, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI87081881, Length=176, Percent_Identity=39.7727272727273, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1787541, Length=268, Percent_Identity=27.6119402985075, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1786584, Length=167, Percent_Identity=33.5329341317365, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1787262, Length=163, Percent_Identity=32.5153374233129, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI145693134, Length=166, Percent_Identity=33.7349397590361, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788956, Length=165, Percent_Identity=36.3636363636364, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787802, Length=160, Percent_Identity=33.125, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082007, Length=184, Percent_Identity=31.5217391304348, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI87081977, Length=202, Percent_Identity=28.7128712871287, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1787816, Length=165, Percent_Identity=32.7272727272727, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI87081974, Length=111, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 73591; Mature: 73460

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLLPSLKVRIALITTVLAGILGGGIVIGSLYFAHLDLEDALQNQQDSIVKLSVDQLDT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEHHHHHH
AMDDRIELLSHLAPQLRDTLASAHEQPHDAVRAALQQAIDRTIPMPEAFNAVMVVDAAGT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
VLTMDGKPVEVGDRAYFLEAIRTRNVVVAAPIRSRVGGYVGVLVAVPVLSLSGEFLGVAG
EEEECCCCCCCCCHHHHHHHHHHCCEEEECCHHHHHCHHHHHHHHHHHHHCCCCEEEECC
GWLNLANSNFLVEIANNRLGTTGFYCLVSAGSEPVYVQHPDPTMARKPAHAVGETCGVDD
CHHEECCCCEEEEECCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCHHHHHCCCCCCC
HSAPLEFLTPTRPVIARRLMASTGWELVAVMPAQEAYAPLRQMQRRFLMMSAIALSVVAL
CCCCCHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIWLAVRQLLTPLSRLHQVVQASANDLDAFQRLPKRPHRDEIGDVTGAFIRLMRDMRQRG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LQLARSERRLRAVTDTLPALLAFIDSDERYVFNNIAYERVFGMSLDEIQGKTVREVLGEE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCHHHHCCHHHHHHHCHH
RYARAQPFLQRALRGEEVSFEAEYHFPHHHWMEMNYRPEWGEDGRQVVGVHIHVEDITRR
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCEEEEEEEEHHHHHHH
KVENLRLSHISRTDHLTQLQNRNAFESQLRDAMMLSRAEQQLMALLYLDMDRFKAVNDIH
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHATGDLLLQAFALRLRRCVRESDHVARIGGDEFAVILEDIGTPATAQRIAGAILESVGR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCC
HFYFDGILADVDVSIGVTLYKGTPISEETLMRQADVLLYRAKALGRGRYEIGPAELLADA
CEEECCCCEECEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
GA
CC
>Mature Secondary Structure 
PRLLPSLKVRIALITTVLAGILGGGIVIGSLYFAHLDLEDALQNQQDSIVKLSVDQLDT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEHHHHHH
AMDDRIELLSHLAPQLRDTLASAHEQPHDAVRAALQQAIDRTIPMPEAFNAVMVVDAAGT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
VLTMDGKPVEVGDRAYFLEAIRTRNVVVAAPIRSRVGGYVGVLVAVPVLSLSGEFLGVAG
EEEECCCCCCCCCHHHHHHHHHHCCEEEECCHHHHHCHHHHHHHHHHHHHCCCCEEEECC
GWLNLANSNFLVEIANNRLGTTGFYCLVSAGSEPVYVQHPDPTMARKPAHAVGETCGVDD
CHHEECCCCEEEEECCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCHHHHHCCCCCCC
HSAPLEFLTPTRPVIARRLMASTGWELVAVMPAQEAYAPLRQMQRRFLMMSAIALSVVAL
CCCCCHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIWLAVRQLLTPLSRLHQVVQASANDLDAFQRLPKRPHRDEIGDVTGAFIRLMRDMRQRG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LQLARSERRLRAVTDTLPALLAFIDSDERYVFNNIAYERVFGMSLDEIQGKTVREVLGEE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCHHHHCCHHHHHHHCHH
RYARAQPFLQRALRGEEVSFEAEYHFPHHHWMEMNYRPEWGEDGRQVVGVHIHVEDITRR
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCEEEEEEEEHHHHHHH
KVENLRLSHISRTDHLTQLQNRNAFESQLRDAMMLSRAEQQLMALLYLDMDRFKAVNDIH
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHATGDLLLQAFALRLRRCVRESDHVARIGGDEFAVILEDIGTPATAQRIAGAILESVGR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCC
HFYFDGILADVDVSIGVTLYKGTPISEETLMRQADVLLYRAKALGRGRYEIGPAELLADA
CEEECCCCEECEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]