Click here to switch to the map view.

The map label for this gene is bvgS2 [H]

Identifier: 94314643

GI number: 94314643

Start: 2481279

End: 2483633

Strand: Direct

Name: bvgS2 [H]

Synonym: Rmet_5724

Alternate gene names: 94314643

Gene position: 2481279-2483633 (Clockwise)

Preceding gene: 94314642

Following gene: 291481603

Centisome position: 96.17

GC content: 57.49

Gene sequence:

>2355_bases
ATGCTCCATCTTTCGGCGGCCTATTTCGTGACTCCGTTTGCCCTGCTCGCTGCAATGATGCTCGTAGTGGCACGTTGCTG
GCGCAACGCCAGACAGGCAAGCGCCAAGATGGCAGAACTCAAGGCCGAGCGCACCCTTTTCCAGTCGTTGCTGGACTCCT
CGCCCAATGCGGTACTGGTGGTGAGCCACGAGCACCGCATCCTCAAAGTCAGCGAACCTTACGCAAGGCTGTGCGGCGTC
AGTACCGAAGATCTCATCGGGAAGCCATTGGTCCACAGCCACACGACAAGCCGCTTTCTCGATCTGGGTGGTCTACTGGA
ACTCACCCTGCTCAGAATGGACGGCAATGAACGCTCCGATCTAATCACTCTCGGAATTCCGGAGCAATCTGTACGCACAT
TCAGGGTGAACGCCACACAATGCAGATCGGAAGATGGCGTGTTCTCGGGTACCGCGATAGTGCTGACGGATATCAGCGAA
CAGGTGGCAGCGCAGCATCGCGTCGATCAGACTTCCGCAGCCATGGATGACATCACTGATGCGCTATCGGTGACGTTCTT
CCAGCTCTGTCGCGAATCAAACGGCCATATCTGGCTTCCCTGGGTGAAGGGGATGCAAAACACCACGCTGAACTGGTCAG
CCGAGAGAATGATGCGCGACGGCGGTGGCATCCTTCCGAATCTTGATGCCTCCGAAAAGACACTATTCATCGGGGCAGTA
GACCAATCCATCGCAACGCAGCAGCCGATGGATGTTACCGTGCGCCTCACCTCGGATAACCGGTGGGTACACATCGCCAG
TGGCAATCCGAGAGTTGGCCCCAATGGCGCAACACTCTGGTATGCCTATGCGATGGACGTAACCGAAATGCAGCGCTACA
ACACGCTTCTGGCTACGGCCAGTCGTGAGGCCGAAGCTGCCACGGAAGCCAAGTCTCGTTTTCTGGCCACAATGAGTCAT
GAAATTCGCACGCCACTGGCCACGGTCATTGCCTCGCTGGACCTGCTGCGCGAGAGCGAACTCTCCACCCACCAGCGGGA
AGAACTGGATCTGGCCGATCATTCGGCCAAGCTTCTCCTGGAGATTCTCGGCGATATCCTCGACTTTTCCAGGATCGAAG
CAGGGGAGATGAAGCTTGAACAGGCGCCGATTGACCTGCGACTGATCATCGAGGATGTTCTGCGCATCCAGGCGCGCCAA
ATCGAAAAGAAGGGCGTGATACTCGACTTCTACGTGGAAGCGGGGCTGGCCGCGACGTTGCTTGGCGATGCAGTGCGGCT
CAGGCAGATCGTGCTCAATCTCGTGGGTAATGCTACAAAATTCACGCTTCAGGGCAGCATCGTTGTTCGAGCATTGTTGA
TAGCGGACCATCCCGAAACACAGACGATTCAACTGGAAGTCAGCGACACTGGTATCGGAATCCCCGCGGAGAAGCAAGCC
GCTCTCTTCAAGGCATTTTCTCAGGCTGATGTCTCCACAACGCGCCGATTCGGGGGCAGTGGTCTGGGGCTGTCGATTTG
CTCCAGGCTCGTTCAAGCCATGGGTGGGGCCGTCGTCTTGACTAGTACGCCAGGTGTCGGCAGCACGTTCCGCGTGGAAC
TGACGCTGCCCGTCGTCGAGCGCAGCACGCGGATGGTGGAGTTTGCAAAAACTCACATCGCGATTGATGTGTCGCGTGCA
GATGACGCAGCAGTGTTTCGTGAGCACGCTGTTGCACTCGGTATGCAGCTTGCCCCCCTTGATTGCCTGAATCCTTCCGA
TATTGCTGTGATTGATGAAGACGCCGCCTCAGACAAAGTGCCTGTGGGCGTGCTGACCATCCCTTACGGGAAAAAGCACG
GCAATCTGTCTGGCCCACCCATCTGGTGGAGCGAGTTTCGCGCGGCATGTCTCGATGCAGTTCTTCGCGATACGCATCGG
TTTCCCGCGCAAGGTCAAGATGTCACGGCAACACCACCGATCTCCGATTCGCTGGCCGGTCTGACATCTCTACCGATTCT
CGTCGCGGAAGATCACACACCATTCCAGATCGTAATTCGCAGGCAGATTGAAAAGCTTGGTCTGGCATGTGACGTCGTAT
CCGACGGAAAGGAGGCGCTGGCTGCGATTCGCAACAAGCAATATGGCATGATCCTGACCGACTGCCACATGCCGTATATG
GACGGCTACGAACTCACCAGCGCGATTCGGGCATCCGAGGCTCAAGGACAACGGCTCCCGATTGTCGCGCTGAGCGCGGA
TGCTTCGGATGAGCAAAGACACCGCGGCCGTGCCGCCGGTATGGACGACTTCCTGCTCAAGCCGCTCAAACTCCCGGAAC
TACGCGCGTGCATCCAGCGGTGGGTGCTTCGGTGA

Upstream 100 bases:

>100_bases
CTGCAATTCTTGATTTTCAACTAGCATCATGGAGTGCCGCCTCCAATCGTCGGGGACGGTGGTTGTCGTATTGACACTGC
CTGGGACTTCGTGACGCACC

Downstream 100 bases:

>100_bases
TTCCAGGTCGGTGGCCTCTGGGATAGCCTGCCACGGCCCCGGCGTGCGAGCTGGCGCCCTCCTTACCGGAAACTCCTCCA
CGTCGGGACGCCGCACTCAG

Product: sensor protein, histidine kinase-response regulator

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MLHLSAAYFVTPFALLAAMMLVVARCWRNARQASAKMAELKAERTLFQSLLDSSPNAVLVVSHEHRILKVSEPYARLCGV
STEDLIGKPLVHSHTTSRFLDLGGLLELTLLRMDGNERSDLITLGIPEQSVRTFRVNATQCRSEDGVFSGTAIVLTDISE
QVAAQHRVDQTSAAMDDITDALSVTFFQLCRESNGHIWLPWVKGMQNTTLNWSAERMMRDGGGILPNLDASEKTLFIGAV
DQSIATQQPMDVTVRLTSDNRWVHIASGNPRVGPNGATLWYAYAMDVTEMQRYNTLLATASREAEAATEAKSRFLATMSH
EIRTPLATVIASLDLLRESELSTHQREELDLADHSAKLLLEILGDILDFSRIEAGEMKLEQAPIDLRLIIEDVLRIQARQ
IEKKGVILDFYVEAGLAATLLGDAVRLRQIVLNLVGNATKFTLQGSIVVRALLIADHPETQTIQLEVSDTGIGIPAEKQA
ALFKAFSQADVSTTRRFGGSGLGLSICSRLVQAMGGAVVLTSTPGVGSTFRVELTLPVVERSTRMVEFAKTHIAIDVSRA
DDAAVFREHAVALGMQLAPLDCLNPSDIAVIDEDAASDKVPVGVLTIPYGKKHGNLSGPPIWWSEFRAACLDAVLRDTHR
FPAQGQDVTATPPISDSLAGLTSLPILVAEDHTPFQIVIRRQIEKLGLACDVVSDGKEALAAIRNKQYGMILTDCHMPYM
DGYELTSAIRASEAQGQRLPIVALSADASDEQRHRGRAAGMDDFLLKPLKLPELRACIQRWVLR

Sequences:

>Translated_784_residues
MLHLSAAYFVTPFALLAAMMLVVARCWRNARQASAKMAELKAERTLFQSLLDSSPNAVLVVSHEHRILKVSEPYARLCGV
STEDLIGKPLVHSHTTSRFLDLGGLLELTLLRMDGNERSDLITLGIPEQSVRTFRVNATQCRSEDGVFSGTAIVLTDISE
QVAAQHRVDQTSAAMDDITDALSVTFFQLCRESNGHIWLPWVKGMQNTTLNWSAERMMRDGGGILPNLDASEKTLFIGAV
DQSIATQQPMDVTVRLTSDNRWVHIASGNPRVGPNGATLWYAYAMDVTEMQRYNTLLATASREAEAATEAKSRFLATMSH
EIRTPLATVIASLDLLRESELSTHQREELDLADHSAKLLLEILGDILDFSRIEAGEMKLEQAPIDLRLIIEDVLRIQARQ
IEKKGVILDFYVEAGLAATLLGDAVRLRQIVLNLVGNATKFTLQGSIVVRALLIADHPETQTIQLEVSDTGIGIPAEKQA
ALFKAFSQADVSTTRRFGGSGLGLSICSRLVQAMGGAVVLTSTPGVGSTFRVELTLPVVERSTRMVEFAKTHIAIDVSRA
DDAAVFREHAVALGMQLAPLDCLNPSDIAVIDEDAASDKVPVGVLTIPYGKKHGNLSGPPIWWSEFRAACLDAVLRDTHR
FPAQGQDVTATPPISDSLAGLTSLPILVAEDHTPFQIVIRRQIEKLGLACDVVSDGKEALAAIRNKQYGMILTDCHMPYM
DGYELTSAIRASEAQGQRLPIVALSADASDEQRHRGRAAGMDDFLLKPLKLPELRACIQRWVLR
>Mature_784_residues
MLHLSAAYFVTPFALLAAMMLVVARCWRNARQASAKMAELKAERTLFQSLLDSSPNAVLVVSHEHRILKVSEPYARLCGV
STEDLIGKPLVHSHTTSRFLDLGGLLELTLLRMDGNERSDLITLGIPEQSVRTFRVNATQCRSEDGVFSGTAIVLTDISE
QVAAQHRVDQTSAAMDDITDALSVTFFQLCRESNGHIWLPWVKGMQNTTLNWSAERMMRDGGGILPNLDASEKTLFIGAV
DQSIATQQPMDVTVRLTSDNRWVHIASGNPRVGPNGATLWYAYAMDVTEMQRYNTLLATASREAEAATEAKSRFLATMSH
EIRTPLATVIASLDLLRESELSTHQREELDLADHSAKLLLEILGDILDFSRIEAGEMKLEQAPIDLRLIIEDVLRIQARQ
IEKKGVILDFYVEAGLAATLLGDAVRLRQIVLNLVGNATKFTLQGSIVVRALLIADHPETQTIQLEVSDTGIGIPAEKQA
ALFKAFSQADVSTTRRFGGSGLGLSICSRLVQAMGGAVVLTSTPGVGSTFRVELTLPVVERSTRMVEFAKTHIAIDVSRA
DDAAVFREHAVALGMQLAPLDCLNPSDIAVIDEDAASDKVPVGVLTIPYGKKHGNLSGPPIWWSEFRAACLDAVLRDTHR
FPAQGQDVTATPPISDSLAGLTSLPILVAEDHTPFQIVIRRQIEKLGLACDVVSDGKEALAAIRNKQYGMILTDCHMPYM
DGYELTSAIRASEAQGQRLPIVALSADASDEQRHRGRAAGMDDFLLKPLKLPELRACIQRWVLR

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=550, Percent_Identity=30.5454545454545, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=42.741935483871, Blast_Score=195, Evalue=9e-51,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=41.0788381742739, Blast_Score=159, Evalue=8e-40,
Organism=Escherichia coli, GI48994928, Length=270, Percent_Identity=33.7037037037037, Blast_Score=154, Evalue=3e-38,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=35.8267716535433, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=28.0487804878049, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=30.4932735426009, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=27.6859504132231, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=28.3842794759825, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=28.0701754385965, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=224, Percent_Identity=32.1428571428571, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=27.4678111587983, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=252, Percent_Identity=25.7936507936508, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=30.1724137931034, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=342, Percent_Identity=24.8538011695906, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1787894, Length=244, Percent_Identity=27.0491803278689, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=94, Percent_Identity=43.6170212765958, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 85744; Mature: 85744

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLSAAYFVTPFALLAAMMLVVARCWRNARQASAKMAELKAERTLFQSLLDSSPNAVLV
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VSHEHRILKVSEPYARLCGVSTEDLIGKPLVHSHTTSRFLDLGGLLELTLLRMDGNERSD
EECCCEEEEECCCHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCC
LITLGIPEQSVRTFRVNATQCRSEDGVFSGTAIVLTDISEQVAAQHRVDQTSAAMDDITD
EEEECCCCCCCEEEEECHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCHHHHHHHHHHH
ALSVTFFQLCRESNGHIWLPWVKGMQNTTLNWSAERMMRDGGGILPNLDASEKTLFIGAV
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEC
DQSIATQQPMDVTVRLTSDNRWVHIASGNPRVGPNGATLWYAYAMDVTEMQRYNTLLATA
CHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHC
SREAEAATEAKSRFLATMSHEIRTPLATVIASLDLLRESELSTHQREELDLADHSAKLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EILGDILDFSRIEAGEMKLEQAPIDLRLIIEDVLRIQARQIEKKGVILDFYVEAGLAATL
HHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHH
LGDAVRLRQIVLNLVGNATKFTLQGSIVVRALLIADHPETQTIQLEVSDTGIGIPAEKQA
HHHHHHHHHHHHHHHCCCEEEEEECHHHHEEEHHCCCCCCEEEEEEECCCCCCCCCHHHH
ALFKAFSQADVSTTRRFGGSGLGLSICSRLVQAMGGAVVLTSTPGVGSTFRVELTLPVVE
HHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEEHH
RSTRMVEFAKTHIAIDVSRADDAAVFREHAVALGMQLAPLDCLNPSDIAVIDEDAASDKV
CHHHHHHEEHEEEEEEECCCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEECCCCCCCC
PVGVLTIPYGKKHGNLSGPPIWWSEFRAACLDAVLRDTHRFPAQGQDVTATPPISDSLAG
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHCC
LTSLPILVAEDHTPFQIVIRRQIEKLGLACDVVSDGKEALAAIRNKQYGMILTDCHMPYM
HHHCCEEEECCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCEEEEECCCCCC
DGYELTSAIRASEAQGQRLPIVALSADASDEQRHRGRAAGMDDFLLKPLKLPELRACIQR
CCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHH
WVLR
HHCC
>Mature Secondary Structure
MLHLSAAYFVTPFALLAAMMLVVARCWRNARQASAKMAELKAERTLFQSLLDSSPNAVLV
CEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VSHEHRILKVSEPYARLCGVSTEDLIGKPLVHSHTTSRFLDLGGLLELTLLRMDGNERSD
EECCCEEEEECCCHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCC
LITLGIPEQSVRTFRVNATQCRSEDGVFSGTAIVLTDISEQVAAQHRVDQTSAAMDDITD
EEEECCCCCCCEEEEECHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCHHHHHHHHHHH
ALSVTFFQLCRESNGHIWLPWVKGMQNTTLNWSAERMMRDGGGILPNLDASEKTLFIGAV
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEC
DQSIATQQPMDVTVRLTSDNRWVHIASGNPRVGPNGATLWYAYAMDVTEMQRYNTLLATA
CHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHC
SREAEAATEAKSRFLATMSHEIRTPLATVIASLDLLRESELSTHQREELDLADHSAKLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
EILGDILDFSRIEAGEMKLEQAPIDLRLIIEDVLRIQARQIEKKGVILDFYVEAGLAATL
HHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHH
LGDAVRLRQIVLNLVGNATKFTLQGSIVVRALLIADHPETQTIQLEVSDTGIGIPAEKQA
HHHHHHHHHHHHHHHCCCEEEEEECHHHHEEEHHCCCCCCEEEEEEECCCCCCCCCHHHH
ALFKAFSQADVSTTRRFGGSGLGLSICSRLVQAMGGAVVLTSTPGVGSTFRVELTLPVVE
HHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEEHH
RSTRMVEFAKTHIAIDVSRADDAAVFREHAVALGMQLAPLDCLNPSDIAVIDEDAASDKV
CHHHHHHEEHEEEEEEECCCCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEECCCCCCCC
PVGVLTIPYGKKHGNLSGPPIWWSEFRAACLDAVLRDTHRFPAQGQDVTATPPISDSLAG
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHCC
LTSLPILVAEDHTPFQIVIRRQIEKLGLACDVVSDGKEALAAIRNKQYGMILTDCHMPYM
HHHCCEEEECCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCEEEEECCCCCC
DGYELTSAIRASEAQGQRLPIVALSADASDEQRHRGRAAGMDDFLLKPLKLPELRACIQR
CCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHH
WVLR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]