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The map label for this gene is aqpZ [H]

Identifier: 94314624

GI number: 94314624

Start: 2463181

End: 2463885

Strand: Direct

Name: aqpZ [H]

Synonym: Rmet_5705

Alternate gene names: 94314624

Gene position: 2463181-2463885 (Clockwise)

Preceding gene: 94314623

Following gene: 94314625

Centisome position: 95.47

GC content: 64.11

Gene sequence:

>705_bases
ATGAATATTGGCAAACGATTCACGGCCGAATGGCTGGGCACTTTCTGGCTGGTCTTCGGCGGATGCGGCGCCGCGGTTTT
CGCAGCCGCCTTCCCTAACGTTGGTATCGGTCTGCTCGGCGTATCCCTCGCGTTCGGTCTGACGGTCGTCACCATGGCCT
ATGCCATCGGCCCGGTCTCCGGCTGCCACCTCAACCCGGCCGTCACCGTTGGCCTTGCCGTGGCCGGACGCTTCCCGGTC
GCCGAAGCACCGCTGTACATCCTGGCCCAGTTGCTCGGCGCGATCTGCGCCGCCGGCACGCTGCTATACCTGGCAAGCGC
CAATCCCGGCTTCGACCTGATGGCCAATGGCCTGGCAACCAATGGCTACGGCGCGGCGTCGCCGGGCGGTTATGGGCTGC
GAGCGGTGGTAACGACCGAGACACTGATGACCGCGTTCTTCCTGATCATCATCATCGGCGCCACCAGCTACAGGCGCACG
CGCGCAGCAGCACCGGTGGCAATTGGCCTGGCGCTGACGCTGATTCACCTGATCTCGATCCCAATCTCAAACACGTCGGT
CAATCCCGCACGCTCGACGGGTCCGGCGATCATCGTTGGCGGGGTAGCGATTCAGCAGTTGTGGGTTTTCTGGGTCGCAC
CAATCTGCGGCGCGATCCTGGCCGGCCTGCTCGGTCGTCTGCTGTTCGTCAACGAAGCGGACTGA

Upstream 100 bases:

>100_bases
TTAGCCTCGTCGTATATCGGCATATCGAAAATGGCGACCGGCGAGCGGTGGTCGCACCGCGCACGCCCCCTTTTCGATAC
TCGACGGCATACGTTACAAC

Downstream 100 bases:

>100_bases
GAGGCTGATCTCCGCCATGCAGATCCTGTCTCCTTCCGCGCCCGCCCCGCTGGCGGCCAGGCCGGGGCGCAATCGATTCC
TGATTCTGGCAGCGGTGGCC

Product: aquaporin

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MNIGKRFTAEWLGTFWLVFGGCGAAVFAAAFPNVGIGLLGVSLAFGLTVVTMAYAIGPVSGCHLNPAVTVGLAVAGRFPV
AEAPLYILAQLLGAICAAGTLLYLASANPGFDLMANGLATNGYGAASPGGYGLRAVVTTETLMTAFFLIIIIGATSYRRT
RAAAPVAIGLALTLIHLISIPISNTSVNPARSTGPAIIVGGVAIQQLWVFWVAPICGAILAGLLGRLLFVNEAD

Sequences:

>Translated_234_residues
MNIGKRFTAEWLGTFWLVFGGCGAAVFAAAFPNVGIGLLGVSLAFGLTVVTMAYAIGPVSGCHLNPAVTVGLAVAGRFPV
AEAPLYILAQLLGAICAAGTLLYLASANPGFDLMANGLATNGYGAASPGGYGLRAVVTTETLMTAFFLIIIIGATSYRRT
RAAAPVAIGLALTLIHLISIPISNTSVNPARSTGPAIIVGGVAIQQLWVFWVAPICGAILAGLLGRLLFVNEAD
>Mature_234_residues
MNIGKRFTAEWLGTFWLVFGGCGAAVFAAAFPNVGIGLLGVSLAFGLTVVTMAYAIGPVSGCHLNPAVTVGLAVAGRFPV
AEAPLYILAQLLGAICAAGTLLYLASANPGFDLMANGLATNGYGAASPGGYGLRAVVTTETLMTAFFLIIIIGATSYRRT
RAAAPVAIGLALTLIHLISIPISNTSVNPARSTGPAIIVGGVAIQQLWVFWVAPICGAILAGLLGRLLFVNEAD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=231, Percent_Identity=38.0952380952381, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI37694062, Length=223, Percent_Identity=38.1165919282511, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4502179, Length=219, Percent_Identity=36.986301369863, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4755125, Length=233, Percent_Identity=33.0472103004292, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4502181, Length=233, Percent_Identity=33.0472103004292, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI6912506, Length=222, Percent_Identity=34.2342342342342, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI86792455, Length=227, Percent_Identity=32.15859030837, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI157266307, Length=243, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4826645, Length=245, Percent_Identity=31.0204081632653, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4502187, Length=238, Percent_Identity=28.9915966386555, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=58.4541062801932, Blast_Score=237, Evalue=6e-64,
Organism=Escherichia coli, GI1790362, Length=244, Percent_Identity=29.5081967213115, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71993722, Length=235, Percent_Identity=33.1914893617021, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17558372, Length=245, Percent_Identity=29.7959183673469, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24652747, Length=237, Percent_Identity=36.2869198312236, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551084, Length=237, Percent_Identity=36.2869198312236, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24652751, Length=216, Percent_Identity=33.7962962962963, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922038, Length=216, Percent_Identity=33.7962962962963, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550503, Length=238, Percent_Identity=28.1512605042017, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24762346, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24762348, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20130305, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24762344, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17136672, Length=224, Percent_Identity=29.0178571428571, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23833; Mature: 23833

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGKRFTAEWLGTFWLVFGGCGAAVFAAAFPNVGIGLLGVSLAFGLTVVTMAYAIGPVS
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GCHLNPAVTVGLAVAGRFPVAEAPLYILAQLLGAICAAGTLLYLASANPGFDLMANGLAT
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHCCCCC
NGYGAASPGGYGLRAVVTTETLMTAFFLIIIIGATSYRRTRAAAPVAIGLALTLIHLISI
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHC
PISNTSVNPARSTGPAIIVGGVAIQQLWVFWVAPICGAILAGLLGRLLFVNEAD
CCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIGKRFTAEWLGTFWLVFGGCGAAVFAAAFPNVGIGLLGVSLAFGLTVVTMAYAIGPVS
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GCHLNPAVTVGLAVAGRFPVAEAPLYILAQLLGAICAAGTLLYLASANPGFDLMANGLAT
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHCCCCC
NGYGAASPGGYGLRAVVTTETLMTAFFLIIIIGATSYRRTRAAAPVAIGLALTLIHLISI
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHC
PISNTSVNPARSTGPAIIVGGVAIQQLWVFWVAPICGAILAGLLGRLLFVNEAD
CCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]