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The map label for this gene is copS2 [H]

Identifier: 94314592

GI number: 94314592

Start: 2432019

End: 2433407

Strand: Direct

Name: copS2 [H]

Synonym: Rmet_5673

Alternate gene names: 94314592

Gene position: 2432019-2433407 (Clockwise)

Preceding gene: 94314591

Following gene: 94314603

Centisome position: 94.26

GC content: 65.08

Gene sequence:

>1389_bases
ATGCGCGGCTATTCGCTGACCACGCGGCTGACCGCGCTGTTCTCGCTAACCTCGGCCTGCGTGCTGCTCGGGCTTGGCGT
GCTGATCTTCACGGCGATGGACCGGCACTTCGCGGTGGAGGACTACGCGCTGCTGCGCGACAACATGCGCCTCGTTGAGA
AAACCATCGCCGACAACACCGGCAGCACGTTGCCCACGCGCCTGGCGGACGCCTACCAGCATCACAGCGGACTCCTGGTC
TATACGCGCGGCGCCAACGGTCAGGTGCACTACGCCACGCCGGATTTCGACTTTGCCGCAGCGCTGAAGACGTCGATTGA
GGCATCGCGCAAGCATGTCGGCGATGACGACGTCTTCCAATGGACGCAGGACGGCAAGACCTATCGCGGCATGCGTGCCA
CGGTAAACGCGGCGGGAGAACTCACCGACGTGCTGCTGGGGATGGACACCGAGATCCACGAGCATTTCGTCCACGCGTTC
CGCCGATCGCTCGTCTCGTATGTGGCGCTGGCTGTGCTGGCCAGCGGTGTTTTCGGCTGGTGGGCCGCGCGCCGGGGTCT
GGCGCCGTTGCGCGCCATGGCCACGCGTGCGAAGGTCGTCACGGGAGACAAGCTCCATGAGCGGATGCCGGTGGAAGCTG
TTCCCGAGGAAGTGGCCAATCTCGCCGCCAACCTCAATGCGATGCTGGAACGCCTGCAGGATGATTTCCGCCGCCTGTCC
GAATTCTCGTCCGATCTCGCGCACGAACTGCGCACGCCGCTGACCAATCTGATGACGCAGACGCAGGTGGCCTTGTCACA
ACCCCGGGACGCGGAGAAGTATCGGGAAATCCTGGCCTCCAACGCGGAAGAGCTGCAACGCCTGTCGCGAATGGTTTCGG
ACATGCTGTATCTGGCCAAGATGGAACACGGGCTCGACCTGCCGCACAAGGAAACCATTTCCATCGCGCAGGAAGCGGGG
GCGCTGTTCGAGTTCTATGAGGCGCTGGCCGAGGACAAACAGGTGGCACTGCGGCTGCAGGGCGACGGCATCGTCGAGGG
CGACCGCCTGATGCTGCGGCGCGCGCTGAGCAATCTGCTCTCCAACGCGCTGCGCCACACTCCGCAGGCCGGCGCGGTGG
TTGTCGAGGCGCACGCGGAAGGCGACAGCGTGGTGGTGGCGGTGGAAAACGATGGGCCCGAGATTCCGGCCGAGTTGTTG
TCTTCGCTGTTCGATCGGTTCTTCCGTGGCGACAAGTCGAGGCGACGGCCCGAGTCGGACAGCGTCGGGCTCGGGCTCTC
CATCACGCGCGCGATCATGACCGCGCACGGCGGCGGCATCTCGGTCCAGTCGGCGAACGGAAAGACCCGTTTCGTGCTGC
GATTCCCGCCGCGGAACGCGCAAGCCTGA

Upstream 100 bases:

>100_bases
GCCGCCTGCGCGCGAAGATCGACGATGACTTCGACGATAAGCTGATCCAGACCGTGCGTGGCATGGGATATGTGCTGGAA
GCGCCGGAGGATCTGGCCTG

Downstream 100 bases:

>100_bases
TCAGGCGCGCGCGACGCGCGCCTTGCTGCGTTCCAGCACTTCGAAGACCAGCATCCCGGCCGCCATGGCCAGCACGAAGC
CGATGGCCTTTGGATAGCCC

Product: sensory histidine kinase in two-component regulatory system with CopR, senses copper ions

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRGYSLTTRLTALFSLTSACVLLGLGVLIFTAMDRHFAVEDYALLRDNMRLVEKTIADNTGSTLPTRLADAYQHHSGLLV
YTRGANGQVHYATPDFDFAAALKTSIEASRKHVGDDDVFQWTQDGKTYRGMRATVNAAGELTDVLLGMDTEIHEHFVHAF
RRSLVSYVALAVLASGVFGWWAARRGLAPLRAMATRAKVVTGDKLHERMPVEAVPEEVANLAANLNAMLERLQDDFRRLS
EFSSDLAHELRTPLTNLMTQTQVALSQPRDAEKYREILASNAEELQRLSRMVSDMLYLAKMEHGLDLPHKETISIAQEAG
ALFEFYEALAEDKQVALRLQGDGIVEGDRLMLRRALSNLLSNALRHTPQAGAVVVEAHAEGDSVVVAVENDGPEIPAELL
SSLFDRFFRGDKSRRRPESDSVGLGLSITRAIMTAHGGGISVQSANGKTRFVLRFPPRNAQA

Sequences:

>Translated_462_residues
MRGYSLTTRLTALFSLTSACVLLGLGVLIFTAMDRHFAVEDYALLRDNMRLVEKTIADNTGSTLPTRLADAYQHHSGLLV
YTRGANGQVHYATPDFDFAAALKTSIEASRKHVGDDDVFQWTQDGKTYRGMRATVNAAGELTDVLLGMDTEIHEHFVHAF
RRSLVSYVALAVLASGVFGWWAARRGLAPLRAMATRAKVVTGDKLHERMPVEAVPEEVANLAANLNAMLERLQDDFRRLS
EFSSDLAHELRTPLTNLMTQTQVALSQPRDAEKYREILASNAEELQRLSRMVSDMLYLAKMEHGLDLPHKETISIAQEAG
ALFEFYEALAEDKQVALRLQGDGIVEGDRLMLRRALSNLLSNALRHTPQAGAVVVEAHAEGDSVVVAVENDGPEIPAELL
SSLFDRFFRGDKSRRRPESDSVGLGLSITRAIMTAHGGGISVQSANGKTRFVLRFPPRNAQA
>Mature_462_residues
MRGYSLTTRLTALFSLTSACVLLGLGVLIFTAMDRHFAVEDYALLRDNMRLVEKTIADNTGSTLPTRLADAYQHHSGLLV
YTRGANGQVHYATPDFDFAAALKTSIEASRKHVGDDDVFQWTQDGKTYRGMRATVNAAGELTDVLLGMDTEIHEHFVHAF
RRSLVSYVALAVLASGVFGWWAARRGLAPLRAMATRAKVVTGDKLHERMPVEAVPEEVANLAANLNAMLERLQDDFRRLS
EFSSDLAHELRTPLTNLMTQTQVALSQPRDAEKYREILASNAEELQRLSRMVSDMLYLAKMEHGLDLPHKETISIAQEAG
ALFEFYEALAEDKQVALRLQGDGIVEGDRLMLRRALSNLLSNALRHTPQAGAVVVEAHAEGDSVVVAVENDGPEIPAELL
SSLFDRFFRGDKSRRRPESDSVGLGLSITRAIMTAHGGGISVQSANGKTRFVLRFPPRNAQA

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=483, Percent_Identity=34.9896480331263, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1788279, Length=306, Percent_Identity=31.0457516339869, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=31.0502283105023, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=31.2727272727273, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=28.4403669724771, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=29.2418772563177, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789403, Length=390, Percent_Identity=27.1794871794872, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=25.752508361204, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=31.140350877193, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=30.0847457627119, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=26.8085106382979, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787894, Length=310, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=228, Percent_Identity=27.1929824561404, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790861, Length=285, Percent_Identity=25.2631578947368, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=26.7489711934156, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787374, Length=292, Percent_Identity=22.6027397260274, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=25.5506607929515, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50928; Mature: 50928

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGYSLTTRLTALFSLTSACVLLGLGVLIFTAMDRHFAVEDYALLRDNMRLVEKTIADNT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSTLPTRLADAYQHHSGLLVYTRGANGQVHYATPDFDFAAALKTSIEASRKHVGDDDVFQ
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHH
WTQDGKTYRGMRATVNAAGELTDVLLGMDTEIHEHFVHAFRRSLVSYVALAVLASGVFGW
HCCCCCHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAARRGLAPLRAMATRAKVVTGDKLHERMPVEAVPEEVANLAANLNAMLERLQDDFRRLS
HHHHCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFSSDLAHELRTPLTNLMTQTQVALSQPRDAEKYREILASNAEELQRLSRMVSDMLYLAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MEHGLDLPHKETISIAQEAGALFEFYEALAEDKQVALRLQGDGIVEGDRLMLRRALSNLL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
SNALRHTPQAGAVVVEAHAEGDSVVVAVENDGPEIPAELLSSLFDRFFRGDKSRRRPESD
HHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
SVGLGLSITRAIMTAHGGGISVQSANGKTRFVLRFPPRNAQA
CCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRGYSLTTRLTALFSLTSACVLLGLGVLIFTAMDRHFAVEDYALLRDNMRLVEKTIADNT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSTLPTRLADAYQHHSGLLVYTRGANGQVHYATPDFDFAAALKTSIEASRKHVGDDDVFQ
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHH
WTQDGKTYRGMRATVNAAGELTDVLLGMDTEIHEHFVHAFRRSLVSYVALAVLASGVFGW
HCCCCCHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAARRGLAPLRAMATRAKVVTGDKLHERMPVEAVPEEVANLAANLNAMLERLQDDFRRLS
HHHHCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFSSDLAHELRTPLTNLMTQTQVALSQPRDAEKYREILASNAEELQRLSRMVSDMLYLAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MEHGLDLPHKETISIAQEAGALFEFYEALAEDKQVALRLQGDGIVEGDRLMLRRALSNLL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
SNALRHTPQAGAVVVEAHAEGDSVVVAVENDGPEIPAELLSSLFDRFFRGDKSRRRPESD
HHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
SVGLGLSITRAIMTAHGGGISVQSANGKTRFVLRFPPRNAQA
CCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]