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The map label for this gene is copR2 [H]

Identifier: 94314591

GI number: 94314591

Start: 2431333

End: 2432019

Strand: Direct

Name: copR2 [H]

Synonym: Rmet_5672

Alternate gene names: 94314591

Gene position: 2431333-2432019 (Clockwise)

Preceding gene: 94314586

Following gene: 94314592

Centisome position: 94.23

GC content: 65.07

Gene sequence:

>687_bases
ATGAAGCTCCTGGTGGTCGAGGACGAAACCAAGACTGGCGAATACCTGAGGCAGGGCCTGACCGAGGCCGGCTTCATCGT
GGACCTCGTGCATAGCGGGCTGGACGGCCAGCATATGGCGCTGAACGAGTCCTACGACCTGCTGATCCTCGATGTGATGC
TGCCCGATATCGATGGCTGGCGCATCCTGCAGAACATCCGTGCCGCCGGCAATCCCGTGCCGGTGCTGTTCCTGACGGCC
CGTGACAGCGTCGCCGACCGCGTGAAGGGGCTGGAACTCGGCGCGGACGACTACCTCGTCAAGCCGTTCGCGTTCTCCGA
ACTGCTGGCCCGCGTGCGCACGCTGTTGCGCCGGGGTGCCGCGCAGGCACCGGTCGATCGTATCCAGATCGCCGATCTCG
TGCTGGACCTGGCCCGACGCAGAGCCACGCGCGCCGGGCGCAGGATCGTGCTGACCGGCAAGGAATTCGCGCTGCTGGAA
CTGCTGGCCCGCCGCCGTGGCGAGGTATTGCCGCGTTCGCTGATCGCCTCGCAGGTCTGGGACATGAACTTCGACAGCGA
CAGCAATGTGATCGACGTGGCGATCCGCCGCCTGCGCGCGAAGATCGACGATGACTTCGACGATAAGCTGATCCAGACCG
TGCGTGGCATGGGATATGTGCTGGAAGCGCCGGAGGATCTGGCCTGA

Upstream 100 bases:

>100_bases
TTACATTCCGGTAATGTCCGCGTCATGTTCGGACCGCGGCGTACACTTGCGGCGTTTTCCGGGCGCGGGGCCCGGGTGCA
TTGGTTTGACGAGGACACGT

Downstream 100 bases:

>100_bases
TGCGCGGCTATTCGCTGACCACGCGGCTGACCGCGCTGTTCTCGCTAACCTCGGCCTGCGTGCTGCTCGGGCTTGGCGTG
CTGATCTTCACGGCGATGGA

Product: DNA-binding response regulator in two-component regulatory system with CopS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVVEDETKTGEYLRQGLTEAGFIVDLVHSGLDGQHMALNESYDLLILDVMLPDIDGWRILQNIRAAGNPVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGAAQAPVDRIQIADLVLDLARRRATRAGRRIVLTGKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDDKLIQTVRGMGYVLEAPEDLA

Sequences:

>Translated_228_residues
MKLLVVEDETKTGEYLRQGLTEAGFIVDLVHSGLDGQHMALNESYDLLILDVMLPDIDGWRILQNIRAAGNPVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGAAQAPVDRIQIADLVLDLARRRATRAGRRIVLTGKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDDKLIQTVRGMGYVLEAPEDLA
>Mature_228_residues
MKLLVVEDETKTGEYLRQGLTEAGFIVDLVHSGLDGQHMALNESYDLLILDVMLPDIDGWRILQNIRAAGNPVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGAAQAPVDRIQIADLVLDLARRRATRAGRRIVLTGKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDDFDDKLIQTVRGMGYVLEAPEDLA

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=67.1111111111111, Blast_Score=316, Evalue=9e-88,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=55.6053811659193, Blast_Score=246, Evalue=8e-67,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=43.8914027149321, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=39.5652173913043, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.4449339207048, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=39.3665158371041, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=35.8744394618834, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=35.2941176470588, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=34.375, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.3636363636364, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.4736842105263, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.7510917030568, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=28.6343612334802, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.2127659574468, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.0877192982456, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25519; Mature: 25519

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDETKTGEYLRQGLTEAGFIVDLVHSGLDGQHMALNESYDLLILDVMLPDIDGW
CEEEEEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCHH
RILQNIRAAGNPVPVLFLTARDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGA
HHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
AQAPVDRIQIADLVLDLARRRATRAGRRIVLTGKEFALLELLARRRGEVLPRSLIASQVW
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDDFDDKLIQTVRGMGYVLEAPEDLA
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MKLLVVEDETKTGEYLRQGLTEAGFIVDLVHSGLDGQHMALNESYDLLILDVMLPDIDGW
CEEEEEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCHH
RILQNIRAAGNPVPVLFLTARDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGA
HHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
AQAPVDRIQIADLVLDLARRRATRAGRRIVLTGKEFALLELLARRRGEVLPRSLIASQVW
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDDFDDKLIQTVRGMGYVLEAPEDLA
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]