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The map label for this gene is fkpA [H]

Identifier: 94314542

GI number: 94314542

Start: 2379635

End: 2380030

Strand: Reverse

Name: fkpA [H]

Synonym: Rmet_5623

Alternate gene names: 94314542

Gene position: 2380030-2379635 (Counterclockwise)

Preceding gene: 94314544

Following gene: 94314541

Centisome position: 92.25

GC content: 66.67

Gene sequence:

>396_bases
ATGAAGAAACTCTCCCTGATCCTCGCCGCCGTGGCGCTGGGCGCCGCAGGTATCGCGCAGGCTGAAACGCTGCCGTCCGG
CGTGGTGATCGAGCATGTGACCAAGGGCACCGGCGCTTCGCCGAAAGCAACGGATACGGTCAAGGTCCACTACCGCGGCA
CGCTGACCGACGGCAAGGAGTTCGACAGCTCCTACAAGCGCGGCCAGCCGATCTCGTTCCCCCTGAACCGCGTGATCCCG
TGCTGGACCGAGGGCGTGCAGAAGATGCAGGTCGGCGGCAAGGCCAAGCTGACTTGCCCGGCCTCCACGGCCTACGGCGA
GCGCGGCGTGCCGGGCACGATCCCGCCGAACGCGACGCTGAACTTTGAAGTGGAGCTGCTGGGGATTGGCGGCTGA

Upstream 100 bases:

>100_bases
CGCGCAAACAACAGGGTCATGTACACTTGCCGGCTGGCGTCCGCACCGGGTTTGCCTGGCGTAGGCGTCACTCCCGAGAA
CCTGACACGACGAATATCCC

Downstream 100 bases:

>100_bases
CGATTGAAGGGGCCGGCGGATTCAGGGCCGGCTCTCGCTCCACCCCCGTTTCCCCGTGTATAGACCGGGAACGGGGCGCA
AACCATAAGAACAAGAACAT

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MKKLSLILAAVALGAAGIAQAETLPSGVVIEHVTKGTGASPKATDTVKVHYRGTLTDGKEFDSSYKRGQPISFPLNRVIP
CWTEGVQKMQVGGKAKLTCPASTAYGERGVPGTIPPNATLNFEVELLGIGG

Sequences:

>Translated_131_residues
MKKLSLILAAVALGAAGIAQAETLPSGVVIEHVTKGTGASPKATDTVKVHYRGTLTDGKEFDSSYKRGQPISFPLNRVIP
CWTEGVQKMQVGGKAKLTCPASTAYGERGVPGTIPPNATLNFEVELLGIGG
>Mature_131_residues
MKKLSLILAAVALGAAGIAQAETLPSGVVIEHVTKGTGASPKATDTVKVHYRGTLTDGKEFDSSYKRGQPISFPLNRVIP
CWTEGVQKMQVGGKAKLTCPASTAYGERGVPGTIPPNATLNFEVELLGIGG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=50.9433962264151, Blast_Score=97, Evalue=5e-21,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=50.9433962264151, Blast_Score=97, Evalue=5e-21,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=49.0566037735849, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI206725530, Length=130, Percent_Identity=43.0769230769231, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI17149844, Length=130, Percent_Identity=43.0769230769231, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI17149842, Length=130, Percent_Identity=43.0769230769231, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI4503729, Length=100, Percent_Identity=47, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI224809331, Length=105, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI224809329, Length=105, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI224809327, Length=105, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI4758384, Length=105, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI192448443, Length=127, Percent_Identity=36.2204724409449, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=42.4242424242424, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI7706131, Length=87, Percent_Identity=36.7816091954023, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1789745, Length=108, Percent_Identity=56.4814814814815, Blast_Score=115, Evalue=7e-28,
Organism=Escherichia coli, GI87082390, Length=104, Percent_Identity=53.8461538461538, Blast_Score=112, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71993519, Length=101, Percent_Identity=51.4851485148515, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540882, Length=126, Percent_Identity=39.6825396825397, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=89, Percent_Identity=49.438202247191, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=47.3214285714286, Blast_Score=101, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=59.0909090909091, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323566, Length=112, Percent_Identity=40.1785714285714, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=112, Percent_Identity=38.3928571428571, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=49.0566037735849, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=46.2962962962963, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281363946, Length=136, Percent_Identity=39.7058823529412, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17352457, Length=136, Percent_Identity=39.7058823529412, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356629, Length=132, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24647110, Length=110, Percent_Identity=45.4545454545455, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 13607; Mature: 13607

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLSLILAAVALGAAGIAQAETLPSGVVIEHVTKGTGASPKATDTVKVHYRGTLTDGKE
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCHH
FDSSYKRGQPISFPLNRVIPCWTEGVQKMQVGGKAKLTCPASTAYGERGVPGTIPPNATL
HHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEE
NFEVELLGIGG
EEEEEEEEECC
>Mature Secondary Structure
MKKLSLILAAVALGAAGIAQAETLPSGVVIEHVTKGTGASPKATDTVKVHYRGTLTDGKE
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCHH
FDSSYKRGQPISFPLNRVIPCWTEGVQKMQVGGKAKLTCPASTAYGERGVPGTIPPNATL
HHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCEE
NFEVELLGIGG
EEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]