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The map label for this gene is zneS [H]

Identifier: 94314246

GI number: 94314246

Start: 2036008

End: 2037450

Strand: Direct

Name: zneS [H]

Synonym: Rmet_5327

Alternate gene names: 94314246

Gene position: 2036008-2037450 (Clockwise)

Preceding gene: 94314245

Following gene: 94314250

Centisome position: 78.91

GC content: 66.25

Gene sequence:

>1443_bases
ATGGCAGGTGCCGAAGGAAGGCTGAAACACGCCGGGCCAAAGCACTCGGTCCAGCAACGGCTATCCCTCTGGGTATCGCT
GGCGATCCTCGCGGTGGCGCTCATCGGCGGCATCTTTTCGTTTGCCTCCGCGTTCCGCGAAGCCAACATCATGCAGGACG
ACCTGCTGCGGCAGGTGTCGATGCTGTTCGACGCGCAGCATCTGCCCGCGCCCCATCTGGCGGACGCTGGCAGACTGCCG
CACAGCGACGAGGAAGCCCGCGTCATTGTGCAGACCCTGTCACCGGGCGGTGACAGCGCCCGGCAGATACTGGCATTGCC
CGCCAGCGCGCCCGATGGTCTCGGCACCTTCGAAGTCGACCACGAGTCCTACCGCGTGCTGATCCGGACGCTGCCGACCG
GCCAACGCATTGCCGTTGCCCAGGAAACCGGCATGCGCGACGAGATCGCGCGCAACAGCGCACAAGTTACTGTGTTGCCG
TTTCTGGTGCTCGTACCGGTGCTGCTGCTGATCGTGGCCTATCTGGTCCGCCAGATGTTCCGCCCCATCTCCACCCTTTC
CACTGACATCGACCGGCGCGGCGAGCACGAACTGTATCCATTGCCGGAAGACGAGCTTCCCGCCGAAGTCCGTCCTTTCG
TGGTGGCCATCAACCGGCTGCTGGCCCGTATCGCGCAGGCCATGGAGATGCAGCGCCGCTTCGTCGCCGACGCGGCGCAC
GAACTGCGCTCGCCGATGACCGCGCTATCGCTGCAGGCCGAACGGCTCGAACGCACCGAGATGCCCGAGGCGGCGCGCAC
CCGGCTGGCCACCCTGCGGCGCGGCATCGAACGCAGCCGCGCCCTGCTGGAACAGTTGCTGAGTCTCGCACGTGCCCAAT
CGGCAACCGCCGCGCCAGCGCCAGCGGAAAGCATCTCCGTGCGGCACGCCTTCCGGCGCGTGCTGGAAGACCTGATGCCA
CTGGCCGATTCGCGTCACATCGACATTGGCGCGGTTGGCGACACCGACGCGCAGGTGCCAATTCAGGAGGTGGAGCTGAT
CACGCTGCTCAAGAACCTCGTGGACAACGCCATCCGCTATACGCCCAAACACGGCCGCGTCGATCTGTCGGTGGAGACTT
CCCCCAATGCGGTGGCGATGATCGTGACCGATTCCGGACCCGGCATCAGCACGGAGGAACGAAGCAGGATCTTTGATCCG
TTCTACCGGATTCCGGGCAACGACGCGCCCGGCTCCGGCCTTGGTCTCTCCATCGTCCGGGTCATTGCCGAGCGGGTGGG
CGCCACGGTCGAGATCGACTACGCCGACGCGGCCGCGCGCCACGGCACGCGCGTGACGGTGCGCGTGCCGTGTGGTGACA
ACTGTGGTGGCAACTACGGTACCAACGAGAGCGGCGTCCGTCGGCAGCACGCGGCTGCCACCACGGATCAGCCGTTACCC
TGA

Upstream 100 bases:

>100_bases
GCTGGGGCGATGAAGTGGAAAGCAATGCGGTCGAGTTCCTGATCCACGGCCTGCGCAGGAAGCTTGGCAGCACCATCATC
AGAAACGTCAGGGGGGTGGG

Downstream 100 bases:

>100_bases
GCCTTGCCGACGGCCTCCGGCGCTGCGGCCGGCTTGCTGTCCGACTGGTTCTCCGGCGTCTTGCCCGGTTCATCCTCCCA
GCTTCCGCCCAGCGCCTGCA

Product: Periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MAGAEGRLKHAGPKHSVQQRLSLWVSLAILAVALIGGIFSFASAFREANIMQDDLLRQVSMLFDAQHLPAPHLADAGRLP
HSDEEARVIVQTLSPGGDSARQILALPASAPDGLGTFEVDHESYRVLIRTLPTGQRIAVAQETGMRDEIARNSAQVTVLP
FLVLVPVLLLIVAYLVRQMFRPISTLSTDIDRRGEHELYPLPEDELPAEVRPFVVAINRLLARIAQAMEMQRRFVADAAH
ELRSPMTALSLQAERLERTEMPEAARTRLATLRRGIERSRALLEQLLSLARAQSATAAPAPAESISVRHAFRRVLEDLMP
LADSRHIDIGAVGDTDAQVPIQEVELITLLKNLVDNAIRYTPKHGRVDLSVETSPNAVAMIVTDSGPGISTEERSRIFDP
FYRIPGNDAPGSGLGLSIVRVIAERVGATVEIDYADAAARHGTRVTVRVPCGDNCGGNYGTNESGVRRQHAAATTDQPLP

Sequences:

>Translated_480_residues
MAGAEGRLKHAGPKHSVQQRLSLWVSLAILAVALIGGIFSFASAFREANIMQDDLLRQVSMLFDAQHLPAPHLADAGRLP
HSDEEARVIVQTLSPGGDSARQILALPASAPDGLGTFEVDHESYRVLIRTLPTGQRIAVAQETGMRDEIARNSAQVTVLP
FLVLVPVLLLIVAYLVRQMFRPISTLSTDIDRRGEHELYPLPEDELPAEVRPFVVAINRLLARIAQAMEMQRRFVADAAH
ELRSPMTALSLQAERLERTEMPEAARTRLATLRRGIERSRALLEQLLSLARAQSATAAPAPAESISVRHAFRRVLEDLMP
LADSRHIDIGAVGDTDAQVPIQEVELITLLKNLVDNAIRYTPKHGRVDLSVETSPNAVAMIVTDSGPGISTEERSRIFDP
FYRIPGNDAPGSGLGLSIVRVIAERVGATVEIDYADAAARHGTRVTVRVPCGDNCGGNYGTNESGVRRQHAAATTDQPLP
>Mature_479_residues
AGAEGRLKHAGPKHSVQQRLSLWVSLAILAVALIGGIFSFASAFREANIMQDDLLRQVSMLFDAQHLPAPHLADAGRLPH
SDEEARVIVQTLSPGGDSARQILALPASAPDGLGTFEVDHESYRVLIRTLPTGQRIAVAQETGMRDEIARNSAQVTVLPF
LVLVPVLLLIVAYLVRQMFRPISTLSTDIDRRGEHELYPLPEDELPAEVRPFVVAINRLLARIAQAMEMQRRFVADAAHE
LRSPMTALSLQAERLERTEMPEAARTRLATLRRGIERSRALLEQLLSLARAQSATAAPAPAESISVRHAFRRVLEDLMPL
ADSRHIDIGAVGDTDAQVPIQEVELITLLKNLVDNAIRYTPKHGRVDLSVETSPNAVAMIVTDSGPGISTEERSRIFDPF
YRIPGNDAPGSGLGLSIVRVIAERVGATVEIDYADAAARHGTRVTVRVPCGDNCGGNYGTNESGVRRQHAAATTDQPLP

Specific function: Member of a two-component regulatory system qseB/qseC. Activates the flagella regulon by activating transcription of flhDC. May activate qseB by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789403, Length=444, Percent_Identity=33.5585585585586, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1786783, Length=362, Percent_Identity=26.2430939226519, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=28.9855072463768, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787894, Length=259, Percent_Identity=32.046332046332, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790861, Length=271, Percent_Identity=30.6273062730627, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788279, Length=322, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=27.9835390946502, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=26.7148014440433, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=268, Percent_Identity=29.4776119402985, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=23.9130434782609, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789808, Length=303, Percent_Identity=25.7425742574257, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=27.0386266094421, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=281, Percent_Identity=27.7580071174377, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=283, Percent_Identity=25.4416961130742, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=215, Percent_Identity=28.8372093023256, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=25.2252252252252, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52246; Mature: 52115

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAEGRLKHAGPKHSVQQRLSLWVSLAILAVALIGGIFSFASAFREANIMQDDLLRQVS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MLFDAQHLPAPHLADAGRLPHSDEEARVIVQTLSPGGDSARQILALPASAPDGLGTFEVD
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHEEEECCCCCCCCCCEEEC
HESYRVLIRTLPTGQRIAVAQETGMRDEIARNSAQVTVLPFLVLVPVLLLIVAYLVRQMF
CHHHEEEEEECCCCCEEEEEHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RPISTLSTDIDRRGEHELYPLPEDELPAEVRPFVVAINRLLARIAQAMEMQRRFVADAAH
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRSPMTALSLQAERLERTEMPEAARTRLATLRRGIERSRALLEQLLSLARAQSATAAPA
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PAESISVRHAFRRVLEDLMPLADSRHIDIGAVGDTDAQVPIQEVELITLLKNLVDNAIRY
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
TPKHGRVDLSVETSPNAVAMIVTDSGPGISTEERSRIFDPFYRIPGNDAPGSGLGLSIVR
CCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHCHHHCCCCCCCCCCCHHHHHHH
VIAERVGATVEIDYADAAARHGTRVTVRVPCGDNCGGNYGTNESGVRRQHAAATTDQPLP
HHHHHHCCEEEEECHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AGAEGRLKHAGPKHSVQQRLSLWVSLAILAVALIGGIFSFASAFREANIMQDDLLRQVS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MLFDAQHLPAPHLADAGRLPHSDEEARVIVQTLSPGGDSARQILALPASAPDGLGTFEVD
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHEEEECCCCCCCCCCEEEC
HESYRVLIRTLPTGQRIAVAQETGMRDEIARNSAQVTVLPFLVLVPVLLLIVAYLVRQMF
CHHHEEEEEECCCCCEEEEEHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RPISTLSTDIDRRGEHELYPLPEDELPAEVRPFVVAINRLLARIAQAMEMQRRFVADAAH
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRSPMTALSLQAERLERTEMPEAARTRLATLRRGIERSRALLEQLLSLARAQSATAAPA
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PAESISVRHAFRRVLEDLMPLADSRHIDIGAVGDTDAQVPIQEVELITLLKNLVDNAIRY
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
TPKHGRVDLSVETSPNAVAMIVTDSGPGISTEERSRIFDPFYRIPGNDAPGSGLGLSIVR
CCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHCHHHCCCCCCCCCCCHHHHHHH
VIAERVGATVEIDYADAAARHGTRVTVRVPCGDNCGGNYGTNESGVRRQHAAATTDQPLP
HHHHHHCCEEEEECHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 11929534 [H]