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The map label for this gene is gyaR [H]

Identifier: 94314193

GI number: 94314193

Start: 1973454

End: 1974392

Strand: Direct

Name: gyaR [H]

Synonym: Rmet_5274

Alternate gene names: 94314193

Gene position: 1973454-1974392 (Clockwise)

Preceding gene: 94314192

Following gene: 94314194

Centisome position: 76.49

GC content: 67.94

Gene sequence:

>939_bases
ATGAAACCCCGCCTCCTTCAGCATGGCCGACTCCCGGAAAAGACCGAAGCCCAGCTTGCCGAGCAGTTCGATATCCATCC
GTTCTGGGCCGAGACCGATCCCGCCGGCTATCTGGCAAAACACGGTGGCGAGTTCGTGGCGATGACCACGCGCGCCGCGA
TCGGCGTCGATGCCGCGATGCTGGCCGCTCTGCCGAACCTGCGCGTGATCTCGAGCTTCGGCGTGGGCACCGACAAGCTC
GATCTGGAGACGGCCCGCGCGCGCGGCATCGCGGTCGGCTACACGCCGGACGTGCTCAACGACTGCGTGGCGGACACCGC
GTTCGCGCTGCTGATGGACGCCGCGCGACAGGTCAGCGCCGCGGACCGCTTCGTGCGGCGCGGCGAATGGCCCAAGGGCC
CGTATCCGCTGACCACGCGCGTCAGCGGCAAGCGTCTGGGCATCGTCGGTATGGGCCGCATCGGACGGGTCATCGCCAGG
CGTTCGATCGGATTCGACATGGAGGTGCGCTACTTCGGCCGCAAGCCGCAGGACGGTGTCGACTACGGTTTTGAGCCGTC
GCTCGAAGCCCTGGCGAGCTGGGCGGACTTCCTGGTGGTAGCGACGTCGGGTGGCCCGTCCACGCGGCACCTGATCTCGG
CCAGCGTGCTGGAGGCACTCGGGCCGCAGGGCTATCTGATCAACATCGCACGCGGCACGGTGGTGGACGAAGCCGCGCTC
GTCAGCGCGCTGACCGACAAGCGCATCGCGGGCGCAGGGCTCGACGTGTTCGAGCGCGAGCCGCACGTGCCCGAAGCATT
GTTCGCGCTCGACAACGTGGTGCTGCTGCCGCACGTGGCCAGCGGCACGCATGAGACCCGTGCCGCCATGGCCGATCTGG
TATTCGACAACCTCCAGAGCTTCTTCGCCACCGGCGCGGTGCTGAAATCCGCCGTCTGA

Upstream 100 bases:

>100_bases
CAGGACCGAAAGCGTTATGCAAAGATCATCGCCGATAATCATCTGAGCGCGGACTAACCCGCACCCAGCCAAAACACCGA
TAACACAGGACTCTTCTCGC

Downstream 100 bases:

>100_bases
CTTCGCGATCCGAAGTGTAGCCGGGTCGACACCAGGCAGAAATACTGCGCGCCCCGGCCCGGACTACACTGGCATCCCAC
ATCTTCATCGCCCTAACGGA

Product: 2-oxo-carboxylic acid reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKPRLLQHGRLPEKTEAQLAEQFDIHPFWAETDPAGYLAKHGGEFVAMTTRAAIGVDAAMLAALPNLRVISSFGVGTDKL
DLETARARGIAVGYTPDVLNDCVADTAFALLMDAARQVSAADRFVRRGEWPKGPYPLTTRVSGKRLGIVGMGRIGRVIAR
RSIGFDMEVRYFGRKPQDGVDYGFEPSLEALASWADFLVVATSGGPSTRHLISASVLEALGPQGYLINIARGTVVDEAAL
VSALTDKRIAGAGLDVFEREPHVPEALFALDNVVLLPHVASGTHETRAAMADLVFDNLQSFFATGAVLKSAV

Sequences:

>Translated_312_residues
MKPRLLQHGRLPEKTEAQLAEQFDIHPFWAETDPAGYLAKHGGEFVAMTTRAAIGVDAAMLAALPNLRVISSFGVGTDKL
DLETARARGIAVGYTPDVLNDCVADTAFALLMDAARQVSAADRFVRRGEWPKGPYPLTTRVSGKRLGIVGMGRIGRVIAR
RSIGFDMEVRYFGRKPQDGVDYGFEPSLEALASWADFLVVATSGGPSTRHLISASVLEALGPQGYLINIARGTVVDEAAL
VSALTDKRIAGAGLDVFEREPHVPEALFALDNVVLLPHVASGTHETRAAMADLVFDNLQSFFATGAVLKSAV
>Mature_312_residues
MKPRLLQHGRLPEKTEAQLAEQFDIHPFWAETDPAGYLAKHGGEFVAMTTRAAIGVDAAMLAALPNLRVISSFGVGTDKL
DLETARARGIAVGYTPDVLNDCVADTAFALLMDAARQVSAADRFVRRGEWPKGPYPLTTRVSGKRLGIVGMGRIGRVIAR
RSIGFDMEVRYFGRKPQDGVDYGFEPSLEALASWADFLVVATSGGPSTRHLISASVLEALGPQGYLINIARGTVVDEAAL
VSALTDKRIAGAGLDVFEREPHVPEALFALDNVVLLPHVASGTHETRAAMADLVFDNLQSFFATGAVLKSAV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=251, Percent_Identity=40.2390438247012, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI23308577, Length=244, Percent_Identity=34.0163934426229, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557497, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI145580578, Length=226, Percent_Identity=29.646017699115, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI4557499, Length=226, Percent_Identity=29.646017699115, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI145580575, Length=230, Percent_Identity=30, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=37.2990353697749, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1789279, Length=275, Percent_Identity=29.8181818181818, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787645, Length=286, Percent_Identity=25.1748251748252, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=147, Percent_Identity=34.6938775510204, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=259, Percent_Identity=29.7297297297297, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=261, Percent_Identity=26.0536398467433, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=294, Percent_Identity=34.6938775510204, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=292, Percent_Identity=28.4246575342466, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=292, Percent_Identity=27.7397260273973, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=273, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=28.4883720930233, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324964, Length=272, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571528, Length=289, Percent_Identity=35.6401384083045, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=33.8709677419355, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585514, Length=248, Percent_Identity=33.8709677419355, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574282, Length=248, Percent_Identity=33.8709677419355, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574284, Length=248, Percent_Identity=33.8709677419355, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45551003, Length=248, Percent_Identity=33.8709677419355, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=33.0769230769231, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=30.5647840531561, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24585516, Length=244, Percent_Identity=31.9672131147541, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646446, Length=226, Percent_Identity=32.7433628318584, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646448, Length=226, Percent_Identity=32.7433628318584, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646452, Length=226, Percent_Identity=32.7433628318584, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646450, Length=226, Percent_Identity=32.7433628318584, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=32.7433628318584, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33442; Mature: 33442

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRLLQHGRLPEKTEAQLAEQFDIHPFWAETDPAGYLAKHGGEFVAMTTRAAIGVDAAM
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHH
LAALPNLRVISSFGVGTDKLDLETARARGIAVGYTPDVLNDCVADTAFALLMDAARQVSA
HHHCCCCEEEHHCCCCCCCCCHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADRFVRRGEWPKGPYPLTTRVSGKRLGIVGMGRIGRVIARRSIGFDMEVRYFGRKPQDGV
HHHHHHCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCC
DYGFEPSLEALASWADFLVVATSGGPSTRHLISASVLEALGPQGYLINIARGTVVDEAAL
CCCCCCCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
VSALTDKRIAGAGLDVFEREPHVPEALFALDNVVLLPHVASGTHETRAAMADLVFDNLQS
HHHHHHHHHCCCCCHHHCCCCCCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
FFATGAVLKSAV
HHHHHHHHHHCC
>Mature Secondary Structure
MKPRLLQHGRLPEKTEAQLAEQFDIHPFWAETDPAGYLAKHGGEFVAMTTRAAIGVDAAM
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHH
LAALPNLRVISSFGVGTDKLDLETARARGIAVGYTPDVLNDCVADTAFALLMDAARQVSA
HHHCCCCEEEHHCCCCCCCCCHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADRFVRRGEWPKGPYPLTTRVSGKRLGIVGMGRIGRVIARRSIGFDMEVRYFGRKPQDGV
HHHHHHCCCCCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCC
DYGFEPSLEALASWADFLVVATSGGPSTRHLISASVLEALGPQGYLINIARGTVVDEAAL
CCCCCCCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
VSALTDKRIAGAGLDVFEREPHVPEALFALDNVVLLPHVASGTHETRAAMADLVFDNLQS
HHHHHHHHHCCCCCHHHCCCCCCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
FFATGAVLKSAV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA