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The map label for this gene is dhmA1 [H]

Identifier: 94314186

GI number: 94314186

Start: 1965916

End: 1966950

Strand: Direct

Name: dhmA1 [H]

Synonym: Rmet_5267

Alternate gene names: 94314186

Gene position: 1965916-1966950 (Clockwise)

Preceding gene: 94314185

Following gene: 94314187

Centisome position: 76.2

GC content: 62.42

Gene sequence:

>1035_bases
ATGCTCAAAGTCCGTCCGCTGCTGCTCGCAGCCATCGCCCTCTCCGTCCCACTCGCCCAAGCTGCCCACGCTGCCCAGAC
CGCCGATAGCGGCCCGGCCTACGGTCCCCAACTCGAGGGATTCGATTACCCCTATCCGGTTCAGCAATATCGCTTCAGTT
CGCAAGGGCAGCCGCTCGAGATGGCCTACATAGACGTCAAGCCGGAGAAGCCGAACGGCCGCGCCGTGGTACTGCTGCAT
GGCAAGAATTTTTGCGCTGCCACGTGGCAGGAGAGCATCCAGCAGCTCACCGCCGCCGGCTACCGCGTGATTGCCCCCGA
TCAGATCGGCTTCTGCAAATCGACCAAACCGCCGCATTACCAGTATTCGTTCCAGCAACTCGCGCGCAATACCCACGATC
TGCTGGCCTCGATCGGCGTGCACGACGTCACCGTAATCGGCCATTCCACGGGCGGCATGCTGGCGATGCGCTATGCATTG
ATGTATCCGAAGGAAACCGCGCAACTGGTGCTGGTCAACCCGATCGGCCTGGAAGACTGGAAGGCCAAGGGCGTGCCGTC
GCTGTCGGTGGACCAGTGGTACGCGCGCGAACTCAACGTGACAGCCGACCGGATTCGCAATTACGAGAAATCGACGTACT
ACGTGAACCAGTGGAAGCCCGAGTACGAGCCCTGGGTGCAGATGCTGGCCGGCATGAACCGCGGCCCGGGCAAGCAGATC
GTTGCGTGGAACTCGGCACTGCTCTACGACATGATCTATACGCAACCCGTGGTCTATGAGATGAGCGCGATCCAGGCCCC
GACCCTGCTGATGATCGGAGACCGGGACACCACCGCCATCGCCAAGGACGCCGCGCCGCCAGACGTGCAGGCGAAGCTCG
GCCACTACCCCGAACTTGCGAAAGCGACGGCCAGGGCGATTCCGAACACGACACTGGTCGAATTCCCCGACATGGGCCAC
GCGCCACAGATGCAGGATCCGCAGGCGTTCCACAAGGCATTGCTGGAGGGGTTGGCGAAGGTGGGTGGCAAGTAG

Upstream 100 bases:

>100_bases
CACGCACGCCTTCGCCCACGAAGGCCGAGGGGCCGCCCAAGCACGACATGGGCATTTGTGCGACGATTCCCCTCCCGATC
CGCACGCCCCCTTGCGCACC

Downstream 100 bases:

>100_bases
GCGTGACGGGCGGGTGAACGGCAACTGCGATCCCGGGTACCATCCCAGGTACCCGAAATGCCCGCCATGACCTTCGACCT
CTTCGACGCCCTTCCCGCCG

Product: putative alpha/beta hydrolase; putative prolyl aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLKVRPLLLAAIALSVPLAQAAHAAQTADSGPAYGPQLEGFDYPYPVQQYRFSSQGQPLEMAYIDVKPEKPNGRAVVLLH
GKNFCAATWQESIQQLTAAGYRVIAPDQIGFCKSTKPPHYQYSFQQLARNTHDLLASIGVHDVTVIGHSTGGMLAMRYAL
MYPKETAQLVLVNPIGLEDWKAKGVPSLSVDQWYARELNVTADRIRNYEKSTYYVNQWKPEYEPWVQMLAGMNRGPGKQI
VAWNSALLYDMIYTQPVVYEMSAIQAPTLLMIGDRDTTAIAKDAAPPDVQAKLGHYPELAKATARAIPNTTLVEFPDMGH
APQMQDPQAFHKALLEGLAKVGGK

Sequences:

>Translated_344_residues
MLKVRPLLLAAIALSVPLAQAAHAAQTADSGPAYGPQLEGFDYPYPVQQYRFSSQGQPLEMAYIDVKPEKPNGRAVVLLH
GKNFCAATWQESIQQLTAAGYRVIAPDQIGFCKSTKPPHYQYSFQQLARNTHDLLASIGVHDVTVIGHSTGGMLAMRYAL
MYPKETAQLVLVNPIGLEDWKAKGVPSLSVDQWYARELNVTADRIRNYEKSTYYVNQWKPEYEPWVQMLAGMNRGPGKQI
VAWNSALLYDMIYTQPVVYEMSAIQAPTLLMIGDRDTTAIAKDAAPPDVQAKLGHYPELAKATARAIPNTTLVEFPDMGH
APQMQDPQAFHKALLEGLAKVGGK
>Mature_344_residues
MLKVRPLLLAAIALSVPLAQAAHAAQTADSGPAYGPQLEGFDYPYPVQQYRFSSQGQPLEMAYIDVKPEKPNGRAVVLLH
GKNFCAATWQESIQQLTAAGYRVIAPDQIGFCKSTKPPHYQYSFQQLARNTHDLLASIGVHDVTVIGHSTGGMLAMRYAL
MYPKETAQLVLVNPIGLEDWKAKGVPSLSVDQWYARELNVTADRIRNYEKSTYYVNQWKPEYEPWVQMLAGMNRGPGKQI
VAWNSALLYDMIYTQPVVYEMSAIQAPTLLMIGDRDTTAIAKDAAPPDVQAKLGHYPELAKATARAIPNTTLVEFPDMGH
APQMQDPQAFHKALLEGLAKVGGK

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI27597073, Length=120, Percent_Identity=34.1666666666667, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 37983; Mature: 37983

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVRPLLLAAIALSVPLAQAAHAAQTADSGPAYGPQLEGFDYPYPVQQYRFSSQGQPLE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEE
MAYIDVKPEKPNGRAVVLLHGKNFCAATWQESIQQLTAAGYRVIAPDQIGFCKSTKPPHY
EEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
QYSFQQLARNTHDLLASIGVHDVTVIGHSTGGMLAMRYALMYPKETAQLVLVNPIGLEDW
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCH
KAKGVPSLSVDQWYARELNVTADRIRNYEKSTYYVNQWKPEYEPWVQMLAGMNRGPGKQI
HCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEE
VAWNSALLYDMIYTQPVVYEMSAIQAPTLLMIGDRDTTAIAKDAAPPDVQAKLGHYPELA
EEECHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCHHHCCCCCCCCHHHHCCCCHHHH
KATARAIPNTTLVEFPDMGHAPQMQDPQAFHKALLEGLAKVGGK
HHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKVRPLLLAAIALSVPLAQAAHAAQTADSGPAYGPQLEGFDYPYPVQQYRFSSQGQPLE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEE
MAYIDVKPEKPNGRAVVLLHGKNFCAATWQESIQQLTAAGYRVIAPDQIGFCKSTKPPHY
EEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
QYSFQQLARNTHDLLASIGVHDVTVIGHSTGGMLAMRYALMYPKETAQLVLVNPIGLEDW
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCH
KAKGVPSLSVDQWYARELNVTADRIRNYEKSTYYVNQWKPEYEPWVQMLAGMNRGPGKQI
HCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEE
VAWNSALLYDMIYTQPVVYEMSAIQAPTLLMIGDRDTTAIAKDAAPPDVQAKLGHYPELA
EEECHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCHHHCCCCCCCCHHHHCCCCHHHH
KATARAIPNTTLVEFPDMGHAPQMQDPQAFHKALLEGLAKVGGK
HHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]