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The map label for this gene is kynU [H]

Identifier: 94314111

GI number: 94314111

Start: 1886607

End: 1887836

Strand: Reverse

Name: kynU [H]

Synonym: Rmet_5192

Alternate gene names: 94314111

Gene position: 1887836-1886607 (Counterclockwise)

Preceding gene: 94314112

Following gene: 94314110

Centisome position: 73.17

GC content: 64.23

Gene sequence:

>1230_bases
ATGATGATTCGCGAAGACTGTGCCGCGCTGGACGCGGCAGACAAACTGGCGGGCTGCCGCGCACGATTTGCGCTGCCGGC
CGGCACCATCTACCTCGATGGCAATTCCCTGGGCGCGATGCCCGCCAATGTGCCAGCCCGCATGAAGGTGGCCATCGAAC
AGGAATGGGCGGAAGGCCTGATCCGTTCGTGGAACGATGCCGACTGGTATCCCGCGCCGCAGCGCACCGGCGATCGCATT
GCCCGGCTGATTGGCGCCGGGCAGGGTGAAGTGATCGTGGCCGATTCGACCTCGGTCAACCTGTTCAAGGTACTGGTGGC
GGCCACCCGTATGCGGCCCGGCCGCGGCGTGATTCTCGCCGAGCGTACCAATTTCCCGACCGACGTCTACATTGCGGAGA
GCGTTGCGGAGATGACGGGCTGCGAGCTGCGTTGCGTCGATCCCGAAGAGGTGATGTCCGCAATCGACGAGAACGTGGCC
ATCGTCTCGCTGACCCACGTGAACTACAAGACGGGCAAGCGTTACGACATGGAGGCGATGACCCGCCGCGCGCACGAGGC
TGGCGCGCTGGTGGTCTGGGACCTCTGCCACACGGCGGGCGCCATGCCGGTCTACCTGAATCGCTGCGAGGTCGATTTTG
CGGTCGGATGCGGATACAAGTACCTGAACGGCGGCCCCGGTGCGCCTGCGTTCGTGTTCGTCGCCTCGCGCCACCTGGAG
CATGTCCGTCAGCCGCTTTCCGGCTGGCATGGCCACGCTCAGCCATTTGCGTTCACGCACGAGTATGCACCGCATGCCGG
TATCGACCGGATGCTGACGGGTACCGCGCCGCAACTCGGCCTGATTTCGCTGGAGAGCGCGCTGGAAGCGTTCGACGGTG
TCGACATGGAAGCATTGCGCGAGAAGAGCGTGTCGCTGGGCGACCTGTTTATCACACTGGCCGAGCAGGAACTGGCGGGA
TTGGGTTTCACGCTGGCCACGCCGCGTGATGCAGACCAACGCGGCAGCCAGGTATCGCTGCGGCACGCGGAGGGCTACGC
GATCATGCAGGCGCTGATCGCGCGCAACATCATCGGCGATTTCCGCGCCCCTGACATCCTGCGCTTCGGTTTTGCCGCGC
TCTACGTTCGCCACGTTGATATCTGGGACACCATCGCAGCACTGAAGGACATCGTCACAAGCGAGGCGTGGAACACGGAA
GCGTTCCGCACGCGCAAGTCAGTGACCTGA

Upstream 100 bases:

>100_bases
GGACAGGTCCATCCCGGACGCGCGGCCTGACACGCTGGGTTGACGTCCCGACGGGACACCAGCATTTCCACGTCTTTTTC
TTGCAGCATTCCCGCAACCC

Downstream 100 bases:

>100_bases
GTGCAACGGCCAGAACAATAAGAGGAGACAAGCGATGAGGCAGCAACAGGGATTCGACGCAATCGTCGAGCGGGAGCAGG
GGCTGCATCGGGGGCTGTCC

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MMIREDCAALDAADKLAGCRARFALPAGTIYLDGNSLGAMPANVPARMKVAIEQEWAEGLIRSWNDADWYPAPQRTGDRI
ARLIGAGQGEVIVADSTSVNLFKVLVAATRMRPGRGVILAERTNFPTDVYIAESVAEMTGCELRCVDPEEVMSAIDENVA
IVSLTHVNYKTGKRYDMEAMTRRAHEAGALVVWDLCHTAGAMPVYLNRCEVDFAVGCGYKYLNGGPGAPAFVFVASRHLE
HVRQPLSGWHGHAQPFAFTHEYAPHAGIDRMLTGTAPQLGLISLESALEAFDGVDMEALREKSVSLGDLFITLAEQELAG
LGFTLATPRDADQRGSQVSLRHAEGYAIMQALIARNIIGDFRAPDILRFGFAALYVRHVDIWDTIAALKDIVTSEAWNTE
AFRTRKSVT

Sequences:

>Translated_409_residues
MMIREDCAALDAADKLAGCRARFALPAGTIYLDGNSLGAMPANVPARMKVAIEQEWAEGLIRSWNDADWYPAPQRTGDRI
ARLIGAGQGEVIVADSTSVNLFKVLVAATRMRPGRGVILAERTNFPTDVYIAESVAEMTGCELRCVDPEEVMSAIDENVA
IVSLTHVNYKTGKRYDMEAMTRRAHEAGALVVWDLCHTAGAMPVYLNRCEVDFAVGCGYKYLNGGPGAPAFVFVASRHLE
HVRQPLSGWHGHAQPFAFTHEYAPHAGIDRMLTGTAPQLGLISLESALEAFDGVDMEALREKSVSLGDLFITLAEQELAG
LGFTLATPRDADQRGSQVSLRHAEGYAIMQALIARNIIGDFRAPDILRFGFAALYVRHVDIWDTIAALKDIVTSEAWNTE
AFRTRKSVT
>Mature_409_residues
MMIREDCAALDAADKLAGCRARFALPAGTIYLDGNSLGAMPANVPARMKVAIEQEWAEGLIRSWNDADWYPAPQRTGDRI
ARLIGAGQGEVIVADSTSVNLFKVLVAATRMRPGRGVILAERTNFPTDVYIAESVAEMTGCELRCVDPEEVMSAIDENVA
IVSLTHVNYKTGKRYDMEAMTRRAHEAGALVVWDLCHTAGAMPVYLNRCEVDFAVGCGYKYLNGGPGAPAFVFVASRHLE
HVRQPLSGWHGHAQPFAFTHEYAPHAGIDRMLTGTAPQLGLISLESALEAFDGVDMEALREKSVSLGDLFITLAEQELAG
LGFTLATPRDADQRGSQVSLRHAEGYAIMQALIARNIIGDFRAPDILRFGFAALYVRHVDIWDTIAALKDIVTSEAWNTE
AFRTRKSVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=429, Percent_Identity=26.1072261072261, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI74101437, Length=268, Percent_Identity=26.4925373134328, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550466, Length=394, Percent_Identity=29.9492385786802, Blast_Score=164, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6323261, Length=412, Percent_Identity=27.1844660194175, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 44655; Mature: 44655

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIREDCAALDAADKLAGCRARFALPAGTIYLDGNSLGAMPANVPARMKVAIEQEWAEGL
CCCHHHHHHHHHHHHHHCCHHEEECCCCEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHH
IRSWNDADWYPAPQRTGDRIARLIGAGQGEVIVADSTSVNLFKVLVAATRMRPGRGVILA
HHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
ERTNFPTDVYIAESVAEMTGCELRCVDPEEVMSAIDENVAIVSLTHVNYKTGKRYDMEAM
ECCCCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHCCCEEEEEEEEEECCCCCEECHHHH
TRRAHEAGALVVWDLCHTAGAMPVYLNRCEVDFAVGCGYKYLNGGPGAPAFVFVASRHLE
HHHHHHCCCEEEEEHHHHCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
HVRQPLSGWHGHAQPFAFTHEYAPHAGIDRMLTGTAPQLGLISLESALEAFDGVDMEALR
HHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHH
EKSVSLGDLFITLAEQELAGLGFTLATPRDADQRGSQVSLRHAEGYAIMQALIARNIIGD
HCCCCHHHHEEEEEHHHHHCCCEEECCCCCHHHCCCEEEEEECCCHHHHHHHHHHHHHCC
FRAPDILRFGFAALYVRHVDIWDTIAALKDIVTSEAWNTEAFRTRKSVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MMIREDCAALDAADKLAGCRARFALPAGTIYLDGNSLGAMPANVPARMKVAIEQEWAEGL
CCCHHHHHHHHHHHHHHCCHHEEECCCCEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHH
IRSWNDADWYPAPQRTGDRIARLIGAGQGEVIVADSTSVNLFKVLVAATRMRPGRGVILA
HHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
ERTNFPTDVYIAESVAEMTGCELRCVDPEEVMSAIDENVAIVSLTHVNYKTGKRYDMEAM
ECCCCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHCCCEEEEEEEEEECCCCCEECHHHH
TRRAHEAGALVVWDLCHTAGAMPVYLNRCEVDFAVGCGYKYLNGGPGAPAFVFVASRHLE
HHHHHHCCCEEEEEHHHHCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
HVRQPLSGWHGHAQPFAFTHEYAPHAGIDRMLTGTAPQLGLISLESALEAFDGVDMEALR
HHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHH
EKSVSLGDLFITLAEQELAGLGFTLATPRDADQRGSQVSLRHAEGYAIMQALIARNIIGD
HCCCCHHHHEEEEEHHHHHCCCEEECCCCCHHHCCCEEEEEECCCHHHHHHHHHHHHHCC
FRAPDILRFGFAALYVRHVDIWDTIAALKDIVTSEAWNTEAFRTRKSVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA