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The map label for this gene is paaE [H]

Identifier: 94314075

GI number: 94314075

Start: 1854522

End: 1855700

Strand: Reverse

Name: paaE [H]

Synonym: Rmet_5156

Alternate gene names: 94314075

Gene position: 1855700-1854522 (Counterclockwise)

Preceding gene: 94314090

Following gene: 94314074

Centisome position: 71.92

GC content: 66.41

Gene sequence:

>1179_bases
ATGCAGCAAGCTTTCATCATCGACGCAATCCGTTCGCCGCTGGGCCGTTCCAAGCCCGGCTCCGCCTTTACCGAACTCCA
TGCCACCGAACTGCTGGCCCAGGTGCTGTCGCAGCTCGTGCGGCGCAATGACCTTGACCCGGGTCTGGTCGATGACGTCA
TCACCGGTTGCGTGACGCAGGCCGGCGAACAGTCCGCAGGGGTTGGGCGCGTGGCCTGGCTGGCGGCGGGCTTTCCGGAG
CACGTGCCGGCCACCACCATCGACCGCAAGTGCGGTTCGAGCCAGCAGGCCGTTCACTTTGCCGCGCAGGGCATCATGGC
CGGCGCGTACGACATCGTGATTGCCTGCGGCATCGAGTCCATGAGCCGGGTGCCGATGGGCGCGGCGCGTATTGGCCAGA
ACCCATATGGTCCGTCGTTTGAGGAACGCTACGCGCCGGGGCTGGTCGGGCAGGGCGTGTCGGCCGAGCTGGTTGCCGCC
AAGTGGGAGCTTTCGCGTCACGACATGGACAGCTACTCGGCGCGCTCGCACCAGCGTGCCGCCGCCACCCAGGCAGCCGG
CGGATTCAAGCGCGAGATCGTCGGCATCCAGACCGTGAATGGTCTGGTGGAGCAGGACGAGACGATCCGCGCCAACACCA
CCGTGGAGCGCCTGGCGACGCTGGAGTCGCCATTCCGCAACGACGAACTGAGTGCCCGTTTTCCGCAGATCGGCTGGAAT
GTTACCGCCGGCAACGCCTCGCAGATCAGTGATGGTGCGGCCGCAATCCTGATTGTCAGCGAGCGCATGGCCACGAAGCT
CGGCCTCAAGCCGCGCGCGCGTTTTGTCGGTTTCGACGTGATCGGCGCCAATCCGCTGGAGATGCTGACCGCGCCGATCC
CCGCCACCCAGCGCGTGCTGGCAAAGACCGGCATGACGCTCGAGCAGATCGCGCACTACGAAATCAACGAGGCATTCGCC
AGTGTGCCGATGGCCTGGCAGAAGACGATGAAGGCCGATGGCGCGCGCCTGAACCCGCGCGGTGGCGCGATCGCGCTAGG
TCACCCGCTTGGCGCATCGGGCGTGCGGCTGATGACCACCATGCTCCATGCGCTGGAAGACAGCGGCGAGCGCTTCGGCC
TGCAGTCGATGTGCGAAGCGGGCGGCATGGCGAACGCCACGATCATCGAGCGCGTCTGA

Upstream 100 bases:

>100_bases
CTGGACTTTTTGGCTAAATCTGATTGAAGATATGTCACGCCAACCGATATTTTGAGCCACCTATCTCATTTTTCCTACTA
CCAGGATCAGGGGGAGACAC

Downstream 100 bases:

>100_bases
CGCCCATCGCAATCCCATACGAACAGGAAAAACAAGCATGAAACTCGACCAGACCATGTCCGCCGTCGTGACCGGCGGTG
CCTCCGGCCTCGGCCTTGCC

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQQAFIIDAIRSPLGRSKPGSAFTELHATELLAQVLSQLVRRNDLDPGLVDDVITGCVTQAGEQSAGVGRVAWLAAGFPE
HVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIESMSRVPMGAARIGQNPYGPSFEERYAPGLVGQGVSAELVAA
KWELSRHDMDSYSARSHQRAAATQAAGGFKREIVGIQTVNGLVEQDETIRANTTVERLATLESPFRNDELSARFPQIGWN
VTAGNASQISDGAAAILIVSERMATKLGLKPRARFVGFDVIGANPLEMLTAPIPATQRVLAKTGMTLEQIAHYEINEAFA
SVPMAWQKTMKADGARLNPRGGAIALGHPLGASGVRLMTTMLHALEDSGERFGLQSMCEAGGMANATIIERV

Sequences:

>Translated_392_residues
MQQAFIIDAIRSPLGRSKPGSAFTELHATELLAQVLSQLVRRNDLDPGLVDDVITGCVTQAGEQSAGVGRVAWLAAGFPE
HVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIESMSRVPMGAARIGQNPYGPSFEERYAPGLVGQGVSAELVAA
KWELSRHDMDSYSARSHQRAAATQAAGGFKREIVGIQTVNGLVEQDETIRANTTVERLATLESPFRNDELSARFPQIGWN
VTAGNASQISDGAAAILIVSERMATKLGLKPRARFVGFDVIGANPLEMLTAPIPATQRVLAKTGMTLEQIAHYEINEAFA
SVPMAWQKTMKADGARLNPRGGAIALGHPLGASGVRLMTTMLHALEDSGERFGLQSMCEAGGMANATIIERV
>Mature_392_residues
MQQAFIIDAIRSPLGRSKPGSAFTELHATELLAQVLSQLVRRNDLDPGLVDDVITGCVTQAGEQSAGVGRVAWLAAGFPE
HVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIESMSRVPMGAARIGQNPYGPSFEERYAPGLVGQGVSAELVAA
KWELSRHDMDSYSARSHQRAAATQAAGGFKREIVGIQTVNGLVEQDETIRANTTVERLATLESPFRNDELSARFPQIGWN
VTAGNASQISDGAAAILIVSERMATKLGLKPRARFVGFDVIGANPLEMLTAPIPATQRVLAKTGMTLEQIAHYEINEAFA
SVPMAWQKTMKADGARLNPRGGAIALGHPLGASGVRLMTTMLHALEDSGERFGLQSMCEAGGMANATIIERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=37.0646766169154, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4501853, Length=382, Percent_Identity=36.6492146596859, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=34.6633416458853, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=33.4975369458128, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI4504327, Length=435, Percent_Identity=29.6551724137931, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI194353979, Length=387, Percent_Identity=27.906976744186, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=41.8886198547215, Blast_Score=270, Evalue=9e-74,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=41.1471321695761, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082165, Length=410, Percent_Identity=37.3170731707317, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=35.9605911330049, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=28.3333333333333, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=404, Percent_Identity=36.8811881188119, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=406, Percent_Identity=31.0344827586207, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=29.6296296296296, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=29.1571753986333, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=27.8195488721804, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=34.3434343434343, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6325229, Length=413, Percent_Identity=33.4140435835351, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=36.1386138613861, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.9853300733496, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17648125, Length=406, Percent_Identity=35.2216748768473, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=30.4147465437788, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41633; Mature: 41633

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQAFIIDAIRSPLGRSKPGSAFTELHATELLAQVLSQLVRRNDLDPGLVDDVITGCVTQ
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEQSAGVGRVAWLAAGFPEHVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIES
CCCCCCCCCHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCHHHEEEEECHHH
MSRVPMGAARIGQNPYGPSFEERYAPGLVGQGVSAELVAAKWELSRHDMDSYSARSHQRA
HHCCCCCHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
AATQAAGGFKREIVGIQTVNGLVEQDETIRANTTVERLATLESPFRNDELSARFPQIGWN
HHHHHCCCHHHHHEEHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
VTAGNASQISDGAAAILIVSERMATKLGLKPRARFVGFDVIGANPLEMLTAPIPATQRVL
EECCCHHHCCCCCEEEEEEHHHHHHHHCCCCCHHEEEEEEECCCHHHHHCCCCCHHHHHH
AKTGMTLEQIAHYEINEAFASVPMAWQKTMKADGARLNPRGGAIALGHPLGASGVRLMTT
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEECCCCCEEEECCCCCCCHHHHHHH
MLHALEDSGERFGLQSMCEAGGMANATIIERV
HHHHHHCCCHHCCHHHHHHHCCCCCCHHEECC
>Mature Secondary Structure
MQQAFIIDAIRSPLGRSKPGSAFTELHATELLAQVLSQLVRRNDLDPGLVDDVITGCVTQ
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGEQSAGVGRVAWLAAGFPEHVPATTIDRKCGSSQQAVHFAAQGIMAGAYDIVIACGIES
CCCCCCCCCHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCHHHEEEEECHHH
MSRVPMGAARIGQNPYGPSFEERYAPGLVGQGVSAELVAAKWELSRHDMDSYSARSHQRA
HHCCCCCHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
AATQAAGGFKREIVGIQTVNGLVEQDETIRANTTVERLATLESPFRNDELSARFPQIGWN
HHHHHCCCHHHHHEEHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
VTAGNASQISDGAAAILIVSERMATKLGLKPRARFVGFDVIGANPLEMLTAPIPATQRVL
EECCCHHHCCCCCEEEEEEHHHHHHHHCCCCCHHEEEEEEECCCHHHHHCCCCCHHHHHH
AKTGMTLEQIAHYEINEAFASVPMAWQKTMKADGARLNPRGGAIALGHPLGASGVRLMTT
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEECCCCCEEEECCCCCCCHHHHHHH
MLHALEDSGERFGLQSMCEAGGMANATIIERV
HHHHHHCCCHHCCHHHHHHHCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA