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The map label for this gene is adhB [H]

Identifier: 94313865

GI number: 94313865

Start: 1608579

End: 1609736

Strand: Direct

Name: adhB [H]

Synonym: Rmet_4943

Alternate gene names: 94313865

Gene position: 1608579-1609736 (Clockwise)

Preceding gene: 94313864

Following gene: 94313866

Centisome position: 62.35

GC content: 67.01

Gene sequence:

>1158_bases
ATGAACCCGTTCCGTTTCCAGACCGTGCCGACGGTCATCGTCGAGCTTGGCGCCGCGCGCCGGCTGGGAGCGTTGCTGCG
CGAGGCCTTTCCGCAATCGCAACGCCTCTGCGTGGTAACCGACGGCTTCCTCTCGAAGAGCGGCCTGCTCTCGCCGGCGC
TCGATGACCTGGGCAAGCACGGCTGGCAGGTGACCCTGATCGACGACGTGATCGCCGACCCGCCCGAGCACATCGTGCTC
GAGGCCACCGAGCGCGCGCGGCAGGCCGATGCGGAAGTCGTACTCGGGCTCGGCGGCGGATCGTCGATGGACGTCGCCAA
GCTGATTGCCGTGCTGCTTCCTGCCGCGCAGTCGCTCAAGGACATGTACGGCGTGAAGAAGGTCACGGGCACGCGGCTGC
CGCTCGTGCAGATGCCGACCACCGCCGGCACCGGCTCGGAAGTGACTGCAGTGTCGATCGTCACCACGGGAGAGACCACC
AAGATGGGGGTGGTGGCGCCGCAGCTTCTGGCCGACCTCGCCATTCTCGACGCCGAACTCACGCTTGGCCTGCCACGTGC
GGCGACCGCGGCCACCGGTATCGACGCGATGGTGCACGCGATCGAGGCCTATACGAGCGCGCATCTGAAGAACCCGATCT
CGGACATGCTGGCCGTGCGCGCGCTGGAACTGCTGTCGCAGAACCTGATGCTCGCCTGCGACAACGGCCACGACCACGGC
GCGCGCGAAGCCATGCTGCTCGGCGCGATGTTCGCCGGCCAGGCCTTCGCCAATTCGCCGGTGGCGGCCGTGCACGCGCT
GGCCTATCCGATCGGCGGCATCTTCCATGTCGCGCACGGGCTCTCCAACGCGCTCGTGCTGCCGCACGTCATGAAGTTCA
ACGCGCCGGCAGCCAGCAAGCTGTATGCGGAACTGGCCGACGTGATACTGCCGGGCACCACCGGTAGCTGCGAAACCAAG
ACGGCCGCGCTGATCGCCCATATCGAGGGACTGGTGCTGGCCACGGGCATCCCGCGCACATTGCGCGAGGTTGGCGTCAA
GGAAAATGATCTGGGCCGTCTGGCCCGCGATGCAATGCTGCAGACACGCCTGCTGGTCAACAATCCGCGCGAGGTCACCG
AGGCCGACGCATTCGCGATCTACAGCGCGGCATTCTGA

Upstream 100 bases:

>100_bases
GATCAAGTATCTTTGCCTGCAGATGTGATTGAGCCCCCCTCTCCCGCTCACTAACAGGGGAGAGGGAAGACAACCCAGAA
AACCACACACCGGAGACCCC

Downstream 100 bases:

>100_bases
CGCGCCCCGGCAACGGGCCCACGATGCGGCCGCCATGGAACCGCCGTGGTCCCGCATTCGGACTACAGTGTAAGAGGCGC
TATCAAAATGAAGCGAAGCG

Product: putative iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MNPFRFQTVPTVIVELGAARRLGALLREAFPQSQRLCVVTDGFLSKSGLLSPALDDLGKHGWQVTLIDDVIADPPEHIVL
EATERARQADAEVVLGLGGGSSMDVAKLIAVLLPAAQSLKDMYGVKKVTGTRLPLVQMPTTAGTGSEVTAVSIVTTGETT
KMGVVAPQLLADLAILDAELTLGLPRAATAATGIDAMVHAIEAYTSAHLKNPISDMLAVRALELLSQNLMLACDNGHDHG
AREAMLLGAMFAGQAFANSPVAAVHALAYPIGGIFHVAHGLSNALVLPHVMKFNAPAASKLYAELADVILPGTTGSCETK
TAALIAHIEGLVLATGIPRTLREVGVKENDLGRLARDAMLQTRLLVNNPREVTEADAFAIYSAAF

Sequences:

>Translated_385_residues
MNPFRFQTVPTVIVELGAARRLGALLREAFPQSQRLCVVTDGFLSKSGLLSPALDDLGKHGWQVTLIDDVIADPPEHIVL
EATERARQADAEVVLGLGGGSSMDVAKLIAVLLPAAQSLKDMYGVKKVTGTRLPLVQMPTTAGTGSEVTAVSIVTTGETT
KMGVVAPQLLADLAILDAELTLGLPRAATAATGIDAMVHAIEAYTSAHLKNPISDMLAVRALELLSQNLMLACDNGHDHG
AREAMLLGAMFAGQAFANSPVAAVHALAYPIGGIFHVAHGLSNALVLPHVMKFNAPAASKLYAELADVILPGTTGSCETK
TAALIAHIEGLVLATGIPRTLREVGVKENDLGRLARDAMLQTRLLVNNPREVTEADAFAIYSAAF
>Mature_385_residues
MNPFRFQTVPTVIVELGAARRLGALLREAFPQSQRLCVVTDGFLSKSGLLSPALDDLGKHGWQVTLIDDVIADPPEHIVL
EATERARQADAEVVLGLGGGSSMDVAKLIAVLLPAAQSLKDMYGVKKVTGTRLPLVQMPTTAGTGSEVTAVSIVTTGETT
KMGVVAPQLLADLAILDAELTLGLPRAATAATGIDAMVHAIEAYTSAHLKNPISDMLAVRALELLSQNLMLACDNGHDHG
AREAMLLGAMFAGQAFANSPVAAVHALAYPIGGIFHVAHGLSNALVLPHVMKFNAPAASKLYAELADVILPGTTGSCETK
TAALIAHIEGLVLATGIPRTLREVGVKENDLGRLARDAMLQTRLLVNNPREVTEADAFAIYSAAF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=401, Percent_Identity=30.1745635910224, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=34.5646437994723, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87082107, Length=352, Percent_Identity=35.2272727272727, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1789163, Length=369, Percent_Identity=32.2493224932249, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1787493, Length=371, Percent_Identity=33.6927223719677, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789386, Length=356, Percent_Identity=24.438202247191, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17537053, Length=390, Percent_Identity=25.6410256410256, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321181, Length=355, Percent_Identity=34.3661971830986, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24657991, Length=407, Percent_Identity=29.97542997543, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40365; Mature: 40365

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPFRFQTVPTVIVELGAARRLGALLREAFPQSQRLCVVTDGFLSKSGLLSPALDDLGKH
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHCC
GWQVTLIDDVIADPPEHIVLEATERARQADAEVVLGLGGGSSMDVAKLIAVLLPAAQSLK
CCEEEEEHHHHCCCCCCEEEECHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
DMYGVKKVTGTRLPLVQMPTTAGTGSEVTAVSIVTTGETTKMGVVAPQLLADLAILDAEL
HHHCHHHHCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
TLGLPRAATAATGIDAMVHAIEAYTSAHLKNPISDMLAVRALELLSQNLMLACDNGHDHG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCC
AREAMLLGAMFAGQAFANSPVAAVHALAYPIGGIFHVAHGLSNALVLPHVMKFNAPAASK
HHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHH
LYAELADVILPGTTGSCETKTAALIAHIEGLVLATGIPRTLREVGVKENDLGRLARDAML
HHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHCCCCCCHHHHHHHHHHH
QTRLLVNNPREVTEADAFAIYSAAF
HHHHHHCCCHHHHHHHHHHHEEECC
>Mature Secondary Structure
MNPFRFQTVPTVIVELGAARRLGALLREAFPQSQRLCVVTDGFLSKSGLLSPALDDLGKH
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHCC
GWQVTLIDDVIADPPEHIVLEATERARQADAEVVLGLGGGSSMDVAKLIAVLLPAAQSLK
CCEEEEEHHHHCCCCCCEEEECHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
DMYGVKKVTGTRLPLVQMPTTAGTGSEVTAVSIVTTGETTKMGVVAPQLLADLAILDAEL
HHHCHHHHCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
TLGLPRAATAATGIDAMVHAIEAYTSAHLKNPISDMLAVRALELLSQNLMLACDNGHDHG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCC
AREAMLLGAMFAGQAFANSPVAAVHALAYPIGGIFHVAHGLSNALVLPHVMKFNAPAASK
HHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHH
LYAELADVILPGTTGSCETKTAALIAHIEGLVLATGIPRTLREVGVKENDLGRLARDAML
HHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHCCCCCCHHHHHHHHHHH
QTRLLVNNPREVTEADAFAIYSAAF
HHHHHHCCCHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]