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The map label for this gene is hpd [H]

Identifier: 94313847

GI number: 94313847

Start: 1586912

End: 1587985

Strand: Direct

Name: hpd [H]

Synonym: Rmet_4925

Alternate gene names: 94313847

Gene position: 1586912-1587985 (Clockwise)

Preceding gene: 94313845

Following gene: 94313848

Centisome position: 61.51

GC content: 62.01

Gene sequence:

>1074_bases
ATGGCCGACCTCTTTGAAAACCCGATGAAGCTGATGGGCTTCGAGTTCGTTGAATTCGCCTCGCCCACGCCCAACGTCCT
TGAACCGCTGTTCGAGAAAATGGGCTTCACCCTGGTGGCCCGTCACCGCTCGAAGGACGTCGTGCTGTACCGCCAGGGCG
ACATCAATTTCATCGTCAACAACGAGCCGCATAGCCCCGCCGCCTATTTCGCCGCCGAACACGGCCCGAGCGCCTGTGGC
ATGGCATTCCGCGTCAAGGATTCCCACCAGGCCTACAACCGCGCGCTGATGCTGGGCGCCCAGCCGGTGGAAATCGCTAC
CGGCCCGATGGAACTGCGCCTGCCCGCGATCAAGGGCATCGGCGGCGCGCCGCTCTACCTGATCGACCGTTTCGAAGACG
GCAAGTCGATCTATGACATCGACTTCGAATTCATCGAGGGCGTGGACCGCCACCCGAAGGGCCACGGCCTGAAGCTGATC
GACCACCTGACGCACAACGTCTACCGTGGCCGCATGGCGTACTGGGCGAGCTTCTACGAGCGCCTGTTCAACTTCCGCGA
AATCCGTTACTTCGACATCCAGGGCGAATACACGGGCCTGACCTCGAAGGCGATGACCGCGCCGGACGGCAAGATCCGCA
TCCCGCTGAATGAAGAGTCGTCGAAGGGCGCCGGCCAGATCGAGGAATTCCTGATGGCGTTCAATGGCGAAGGCATCCAG
CACATCGCCTTCTCCGTCGACAACCTGATCGAAGTCATCGACAGCCTGCAGATGGCCGGCGTCGAACTGATGACGGCACC
GAACGACTATTACTACCAGGCCCTGGACACTCGTCTGCCGGGCCATGGCCAGCCGGTGGACCAGCTCAAGGCCCGCGGCA
TCCTGCTGGACGGCACGACAGAAGGCGGCAAGCCGCGCCTGCTGCTGCAGATCTTCTCGAAGACTGTGCTCGGCCCGGTG
TTCTTCGAATACATCCAGCGCTCCGGCGACGATGGCTTCGGCGAAGGCAACTTCAAGGCGCTCTTCGAATCGCTCGAACG
CGACCAGATCGAACGCGGCACGCTGAAGGTCTGA

Upstream 100 bases:

>100_bases
TCGCATGTCGAGCAGCGTGGGAAGCGCCTCCGGGTGCCCCCAATCCGTTTCCCCGCCGCAATATTATTTCCACCCCCGCA
TCCGCCCCCGAGCACTGACC

Downstream 100 bases:

>100_bases
TCTTCCGGGGGCTTTCGCCCCCGCCTCCCCGCTTGATACAGATTTGCGCCGGCATCCCCCCGGATGGCGGCGCGCACCCT
GCGCCCGGCGTCACCCACGC

Product: 4-hydroxyphenylpyruvate dioxygenase, oxidoreductase protein

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MADLFENPMKLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVVLYRQGDINFIVNNEPHSPAAYFAAEHGPSACG
MAFRVKDSHQAYNRALMLGAQPVEIATGPMELRLPAIKGIGGAPLYLIDRFEDGKSIYDIDFEFIEGVDRHPKGHGLKLI
DHLTHNVYRGRMAYWASFYERLFNFREIRYFDIQGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HIAFSVDNLIEVIDSLQMAGVELMTAPNDYYYQALDTRLPGHGQPVDQLKARGILLDGTTEGGKPRLLLQIFSKTVLGPV
FFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKV

Sequences:

>Translated_357_residues
MADLFENPMKLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVVLYRQGDINFIVNNEPHSPAAYFAAEHGPSACG
MAFRVKDSHQAYNRALMLGAQPVEIATGPMELRLPAIKGIGGAPLYLIDRFEDGKSIYDIDFEFIEGVDRHPKGHGLKLI
DHLTHNVYRGRMAYWASFYERLFNFREIRYFDIQGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HIAFSVDNLIEVIDSLQMAGVELMTAPNDYYYQALDTRLPGHGQPVDQLKARGILLDGTTEGGKPRLLLQIFSKTVLGPV
FFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKV
>Mature_356_residues
ADLFENPMKLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVVLYRQGDINFIVNNEPHSPAAYFAAEHGPSACGM
AFRVKDSHQAYNRALMLGAQPVEIATGPMELRLPAIKGIGGAPLYLIDRFEDGKSIYDIDFEFIEGVDRHPKGHGLKLID
HLTHNVYRGRMAYWASFYERLFNFREIRYFDIQGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQH
IAFSVDNLIEVIDSLQMAGVELMTAPNDYYYQALDTRLPGHGQPVDQLKARGILLDGTTEGGKPRLLLQIFSKTVLGPVF
FEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKV

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=358, Percent_Identity=27.6536312849162, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI285002264, Length=343, Percent_Identity=27.4052478134111, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI14249394, Length=330, Percent_Identity=28.1818181818182, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=333, Percent_Identity=30.3303303303303, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17550752, Length=226, Percent_Identity=33.1858407079646, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356105, Length=304, Percent_Identity=31.9078947368421, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24667510, Length=304, Percent_Identity=31.9078947368421, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40090; Mature: 39959

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFENPMKLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVVLYRQGDINFIVN
CCCHHHCHHHHHCHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEECCEEEEEC
NEPHSPAAYFAAEHGPSACGMAFRVKDSHQAYNRALMLGAQPVEIATGPMELRLPAIKGI
CCCCCCHHEEEECCCCCCCCEEEEECCHHHHHHHEEEECCCCCEEECCCEEEEEHHHCCC
GGAPLYLIDRFEDGKSIYDIDFEFIEGVDRHPKGHGLKLIDHLTHNVYRGRMAYWASFYE
CCCCEEEEEECCCCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RLFNFREIRYFDIQGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHH
HIAFSVDNLIEVIDSLQMAGVELMTAPNDYYYQALDTRLPGHGQPVDQLKARGILLDGTT
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHCEEEEECCC
EGGKPRLLLQIFSKTVLGPVFFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADLFENPMKLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVVLYRQGDINFIVN
CCHHHCHHHHHCHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEECCEEEEEC
NEPHSPAAYFAAEHGPSACGMAFRVKDSHQAYNRALMLGAQPVEIATGPMELRLPAIKGI
CCCCCCHHEEEECCCCCCCCEEEEECCHHHHHHHEEEECCCCCEEECCCEEEEEHHHCCC
GGAPLYLIDRFEDGKSIYDIDFEFIEGVDRHPKGHGLKLIDHLTHNVYRGRMAYWASFYE
CCCCEEEEEECCCCCEEEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RLFNFREIRYFDIQGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHH
HIAFSVDNLIEVIDSLQMAGVELMTAPNDYYYQALDTRLPGHGQPVDQLKARGILLDGTT
HHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHCEEEEECCC
EGGKPRLLLQIFSKTVLGPVFFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]