Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 94313816

GI number: 94313816

Start: 1557194

End: 1558960

Strand: Reverse

Name: trxB [H]

Synonym: Rmet_4894

Alternate gene names: 94313816

Gene position: 1558960-1557194 (Counterclockwise)

Preceding gene: 94313818

Following gene: 94313815

Centisome position: 60.42

GC content: 65.59

Gene sequence:

>1767_bases
ATGGAGATGACGCGGGCGACATCGGAGACCGATGCCAATCCTGATACCTCGGGTGGCGACGGTGGTCACGAGCCGGTTTC
CGGGCTGGAGGCGCCGTATTCGCTACTGGAATCCCGCAGCCACCAGATGTTTCCAACGCTGACGGCGGCCGAAATCGAGC
GCATTCACCGTTTCGGCGAAGTTAGATCGTGGCGCGCTGGCGAGATGCTTTTCTCGACGGGCGACGTGGGGCGCGGGATG
TACGTCGTCCTGTCCGGCCACACGCGCATCATCCAGCGGGACGGGCTGGGCAACCGCAGCACCATTACCGAGGAAGGGCC
CGGCCAGTTTCTGGCGGAAGTCGGGCAACTGACCGGCAAGCCGGCGCTGGTGGACGCCCTGGCCATCGAGGATACCGTCG
CACTGGTGATTGCCCCCGAGCGCCTGCGTGCGCTGCTGGTGGCAGAGGCCGATTTGGGCGAGCGCATCATGCGGGCGTTG
ATTCTGCGCCGGGTCGGCCTGATCGAGCGCGGCAGTGGCCCGGTCCTGGTGGGACGTGGCACGCAGCCCTTGTTGCTGGC
GCTGCAGGCGTTCCTGCGTCGCAACGGGCACCCGCACAAGGTGATCGATATCGAGACGGATCACGACTCCACCTGTCTAC
TCGATCTCAGCAATGCCCCGCAAAGCGATTTCCCGATGGTGATCTGCCCGGATGGCAGCATCCTGCGCGCGCCGGATGAG
GGCCAGCTTGCCAGTTGCCTTGGCCTGGTTCCCGAGTTCGACCCCGAGCATGTCTATGACGTGATCGTCGTCGGCGCTGG
TCCGGCGGGTCTGGCTACGGCTGTCTATGCGGCGTCCGAAGGGTTGTCCGTGGCCGTGATCGATTGCCGCTCGCCGGGCG
GGCAAGCTGGCGCGAGCGCCCGGATCGAGAACTACCTGGGTTTTCCCACCGGCATTTCCGGGCAGGCGCTGGCGGGGCGG
GCCTTCGTCCAGGCGCTCAAGTTCGGTGCGCATCTGGCGATTCCACTGGAAGCAAAGGCGTTGCATTGTGGTGAGAATCC
GATCCGGATCGAACTGTCGGACGGTCGTCAGATTCCCACGCGTACCGTTGTGATCGCCACCGGCGCGCAGTACCGTCGCG
CGGAGATCGACTCGCTCGATCGCTATGAAGGCCGTGGCGTCTACTACTGGGCTTCGCCGGTAGAAGCCAAGCTGTGCAAG
GACGAACACGCGATGCTCGTCGGCGGCGGTAACTCGGCCGGCCAGGCAGCGGTGTTCCTGGCGTCCCACGCTAGGGAGGT
GCACATCCTCGTGCGCGGCGAAGGGCTAGAGGCAACGATGTCGCGCTACCTGATCGACCGCATCCGCAGCCTCCCCAACG
TCACGTTGCACACGCACGCCCAGATCACCGCGCTGGAGGGCGAGGAGTGGCTGTCGATCGTGCGCTATCGGGAGCAAACA
CAGGGTGCCGACTGCATTTCTGTGCCGATGCGCCACGTATTCCTGTTCATCGGCGCGGCGCCCAACACCGAATGGTTGCG
CGCCTGCAATGTGGAGACCGATGCCAAGGGTTTCGTGCTGACCGGATACGAGGCCCATCGCTCCTGCACCGAACGCGCCG
ACTTCACGCTTGAGACGAGCGTGCCGGGCGTGTTCGCGATCGGAGACGTGCGATCCGGCTCGACCAAGCGCGTGGCCGCC
GCCGTGGGTGAGGGCGCGGCGGTCGTTGCGCAGATCCACCGGTATCTGGCGGACCTGCAACCCGTCGCCTTGGCGGTTCG
CATGTGA

Upstream 100 bases:

>100_bases
AAAATCTTCATGTGTACTTGGTGCGAGGCGTGAGGCATGACTACCATCAATCCTTGCGCGGCCGGAGCATCCGGCCACCA
CACGATTGCAAGGGGGAAGC

Downstream 100 bases:

>100_bases
TCGGCTGACTCGCCGTATCCCGGAGTCGGGGTATTCCTGCTTGACATACAGATCTGTCTACATACACTGTGTAGACAGAT
CTGTATCACCACCATCTGAT

Product: cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TR; TRXR [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MEMTRATSETDANPDTSGGDGGHEPVSGLEAPYSLLESRSHQMFPTLTAAEIERIHRFGEVRSWRAGEMLFSTGDVGRGM
YVVLSGHTRIIQRDGLGNRSTITEEGPGQFLAEVGQLTGKPALVDALAIEDTVALVIAPERLRALLVAEADLGERIMRAL
ILRRVGLIERGSGPVLVGRGTQPLLLALQAFLRRNGHPHKVIDIETDHDSTCLLDLSNAPQSDFPMVICPDGSILRAPDE
GQLASCLGLVPEFDPEHVYDVIVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGFPTGISGQALAGR
AFVQALKFGAHLAIPLEAKALHCGENPIRIELSDGRQIPTRTVVIATGAQYRRAEIDSLDRYEGRGVYYWASPVEAKLCK
DEHAMLVGGGNSAGQAAVFLASHAREVHILVRGEGLEATMSRYLIDRIRSLPNVTLHTHAQITALEGEEWLSIVRYREQT
QGADCISVPMRHVFLFIGAAPNTEWLRACNVETDAKGFVLTGYEAHRSCTERADFTLETSVPGVFAIGDVRSGSTKRVAA
AVGEGAAVVAQIHRYLADLQPVALAVRM

Sequences:

>Translated_588_residues
MEMTRATSETDANPDTSGGDGGHEPVSGLEAPYSLLESRSHQMFPTLTAAEIERIHRFGEVRSWRAGEMLFSTGDVGRGM
YVVLSGHTRIIQRDGLGNRSTITEEGPGQFLAEVGQLTGKPALVDALAIEDTVALVIAPERLRALLVAEADLGERIMRAL
ILRRVGLIERGSGPVLVGRGTQPLLLALQAFLRRNGHPHKVIDIETDHDSTCLLDLSNAPQSDFPMVICPDGSILRAPDE
GQLASCLGLVPEFDPEHVYDVIVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGFPTGISGQALAGR
AFVQALKFGAHLAIPLEAKALHCGENPIRIELSDGRQIPTRTVVIATGAQYRRAEIDSLDRYEGRGVYYWASPVEAKLCK
DEHAMLVGGGNSAGQAAVFLASHAREVHILVRGEGLEATMSRYLIDRIRSLPNVTLHTHAQITALEGEEWLSIVRYREQT
QGADCISVPMRHVFLFIGAAPNTEWLRACNVETDAKGFVLTGYEAHRSCTERADFTLETSVPGVFAIGDVRSGSTKRVAA
AVGEGAAVVAQIHRYLADLQPVALAVRM
>Mature_588_residues
MEMTRATSETDANPDTSGGDGGHEPVSGLEAPYSLLESRSHQMFPTLTAAEIERIHRFGEVRSWRAGEMLFSTGDVGRGM
YVVLSGHTRIIQRDGLGNRSTITEEGPGQFLAEVGQLTGKPALVDALAIEDTVALVIAPERLRALLVAEADLGERIMRAL
ILRRVGLIERGSGPVLVGRGTQPLLLALQAFLRRNGHPHKVIDIETDHDSTCLLDLSNAPQSDFPMVICPDGSILRAPDE
GQLASCLGLVPEFDPEHVYDVIVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASARIENYLGFPTGISGQALAGR
AFVQALKFGAHLAIPLEAKALHCGENPIRIELSDGRQIPTRTVVIATGAQYRRAEIDSLDRYEGRGVYYWASPVEAKLCK
DEHAMLVGGGNSAGQAAVFLASHAREVHILVRGEGLEATMSRYLIDRIRSLPNVTLHTHAQITALEGEEWLSIVRYREQT
QGADCISVPMRHVFLFIGAAPNTEWLRACNVETDAKGFVLTGYEAHRSCTERADFTLETSVPGVFAIGDVRSGSTKRVAA
AVGEGAAVVAQIHRYLADLQPVALAVRM

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=323, Percent_Identity=29.7213622291022, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI87081763, Length=331, Percent_Identity=32.02416918429, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320560, Length=335, Percent_Identity=27.4626865671642, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321898, Length=329, Percent_Identity=25.8358662613982, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 63024; Mature: 63024

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMTRATSETDANPDTSGGDGGHEPVSGLEAPYSLLESRSHQMFPTLTAAEIERIHRFGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
VRSWRAGEMLFSTGDVGRGMYVVLSGHTRIIQRDGLGNRSTITEEGPGQFLAEVGQLTGK
HCCCCCCCEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCC
PALVDALAIEDTVALVIAPERLRALLVAEADLGERIMRALILRRVGLIERGSGPVLVGRG
CHHEEEEECCCEEEEEECHHHHEEEEEECCCHHHHHHHHHHHHHHCCEECCCCCEEEECC
TQPLLLALQAFLRRNGHPHKVIDIETDHDSTCLLDLSNAPQSDFPMVICPDGSILRAPDE
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEECCCCCEEECCCC
GQLASCLGLVPEFDPEHVYDVIVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASA
CCHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCH
RIENYLGFPTGISGQALAGRAFVQALKFGAHLAIPLEAKALHCGENPIRIELSDGRQIPT
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCEEEEECCCCCCCC
RTVVIATGAQYRRAEIDSLDRYEGRGVYYWASPVEAKLCKDEHAMLVGGGNSAGQAAVFL
EEEEEECCCCHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCEEEEECCCCCCCEEEEE
ASHAREVHILVRGEGLEATMSRYLIDRIRSLPNVTLHTHAQITALEGEEWLSIVRYREQT
ECCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECEEEEEECCHHHHHHHHHHHHC
QGADCISVPMRHVFLFIGAAPNTEWLRACNVETDAKGFVLTGYEAHRSCTERADFTLETS
CCCCHHHHHHHEEEEEEECCCCHHHHEECCCCCCCCCEEEECCHHHHHHHHHCCEEEECC
VPGVFAIGDVRSGSTKRVAAAVGEGAAVVAQIHRYLADLQPVALAVRM
CCCEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MEMTRATSETDANPDTSGGDGGHEPVSGLEAPYSLLESRSHQMFPTLTAAEIERIHRFGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
VRSWRAGEMLFSTGDVGRGMYVVLSGHTRIIQRDGLGNRSTITEEGPGQFLAEVGQLTGK
HCCCCCCCEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCC
PALVDALAIEDTVALVIAPERLRALLVAEADLGERIMRALILRRVGLIERGSGPVLVGRG
CHHEEEEECCCEEEEEECHHHHEEEEEECCCHHHHHHHHHHHHHHCCEECCCCCEEEECC
TQPLLLALQAFLRRNGHPHKVIDIETDHDSTCLLDLSNAPQSDFPMVICPDGSILRAPDE
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEECCCCCEEECCCC
GQLASCLGLVPEFDPEHVYDVIVVGAGPAGLATAVYAASEGLSVAVIDCRSPGGQAGASA
CCHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCH
RIENYLGFPTGISGQALAGRAFVQALKFGAHLAIPLEAKALHCGENPIRIELSDGRQIPT
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCEEEEECCCCCCCC
RTVVIATGAQYRRAEIDSLDRYEGRGVYYWASPVEAKLCKDEHAMLVGGGNSAGQAAVFL
EEEEEECCCCHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCEEEEECCCCCCCEEEEE
ASHAREVHILVRGEGLEATMSRYLIDRIRSLPNVTLHTHAQITALEGEEWLSIVRYREQT
ECCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECEEEEEECCHHHHHHHHHHHHC
QGADCISVPMRHVFLFIGAAPNTEWLRACNVETDAKGFVLTGYEAHRSCTERADFTLETS
CCCCHHHHHHHEEEEEEECCCCHHHHEECCCCCCCCCEEEECCHHHHHHHHHCCEEEECC
VPGVFAIGDVRSGSTKRVAAAVGEGAAVVAQIHRYLADLQPVALAVRM
CCCEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]