Click here to switch to the map view.

The map label for this gene is nhoA [H]

Identifier: 94313666

GI number: 94313666

Start: 1388281

End: 1389159

Strand: Direct

Name: nhoA [H]

Synonym: Rmet_4744

Alternate gene names: 94313666

Gene position: 1388281-1389159 (Clockwise)

Preceding gene: 94313663

Following gene: 94313667

Centisome position: 53.81

GC content: 67.01

Gene sequence:

>879_bases
ATGCTTGCCGCCGACGAAATCCCCGCTCTCCACCCCGACCAGTTGGTCGCCTGGCTGCGACGCATCGGCATCGCAGAGGT
TCCCGACGCCCCCACGCTACCGGTGCTGAACACGCTGATCGCGGCCCAACTCGCGCACATCCCGTTCGAGAATCTCGACG
CGCTGCTCGGCCGCCGGGTGTCGATCGATCTGCCCTCGGTATTCGAAAAACTCGTGGCGCAGGGCCGCGGCGGCTACTGC
TTCGAGCAGAACACCCTGCTCTGCGCCGGCCTCAAGGCACTCGGTTACGCAGTGACGCCGCTTGCAGCGCGCGTGCGCTG
GCATGTGCCGGAAGCCACGCCGACGGGGCTGTCGCACATGCTCCTGCGCGTAGAAGTGGCGCACGAAAGCTATATCGCCG
ATGTGGGCTTCGGCGGGCCGACGCCGGACCGCGCCTTGTCGCTATCGCTGCCGCCGGATGAAAACACGCCCTATCGTCTG
CATCCCTCCCCGGCAAACGCGCTGACGGGTACGGGTTTTCACTGCCTGGATCTGACGGTGCCCGACGTCAGCGACGACGC
TTCGGGTTGGCAACCGATCTACCGTTTCGACCTGACCCCGCAGCCCTGGATCGATTTCATCGCGCGGAACTGGTACGTCT
CCACGCATCCAGACAGCCACTTCACCCGTACGCTGATGGCCGCGCGTACCGACGGCGACACCCGGCTCGCGCTCGCCAAT
GGCAACCTGAGCGAGCGCTCGCCCGACGGCAGCGTGCGAAAAACCGCCCTGGCGTCGGCCGACGCCGTGATCGACACGCT
GGCAACGCGCTTCCAGATCCGGCTCGATCCCGCCTTGCGCGCCGCGCTGGCGACACGACTGCCAGCGGTGCTCGGATAG

Upstream 100 bases:

>100_bases
TCGCGGCCGTTGCGGCCTTATAGTAGTCACGTCCCGTGCGATTCGGTAGCGTTCCCCCTTCCGTTCGAGCGCCCCCACTA
ATTCCCGCCAGCCCCCCACC

Downstream 100 bases:

>100_bases
AGACCCGGCCGCCATTCCGCGCAGCGGCACACGCCATGCATCGCGTGAATTGCCCGCAGAAAGTTTGCTGATACAGGCAT
CCTGGCACCGCTTTCGTTAT

Product: Arylamine N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MLAADEIPALHPDQLVAWLRRIGIAEVPDAPTLPVLNTLIAAQLAHIPFENLDALLGRRVSIDLPSVFEKLVAQGRGGYC
FEQNTLLCAGLKALGYAVTPLAARVRWHVPEATPTGLSHMLLRVEVAHESYIADVGFGGPTPDRALSLSLPPDENTPYRL
HPSPANALTGTGFHCLDLTVPDVSDDASGWQPIYRFDLTPQPWIDFIARNWYVSTHPDSHFTRTLMAARTDGDTRLALAN
GNLSERSPDGSVRKTALASADAVIDTLATRFQIRLDPALRAALATRLPAVLG

Sequences:

>Translated_292_residues
MLAADEIPALHPDQLVAWLRRIGIAEVPDAPTLPVLNTLIAAQLAHIPFENLDALLGRRVSIDLPSVFEKLVAQGRGGYC
FEQNTLLCAGLKALGYAVTPLAARVRWHVPEATPTGLSHMLLRVEVAHESYIADVGFGGPTPDRALSLSLPPDENTPYRL
HPSPANALTGTGFHCLDLTVPDVSDDASGWQPIYRFDLTPQPWIDFIARNWYVSTHPDSHFTRTLMAARTDGDTRLALAN
GNLSERSPDGSVRKTALASADAVIDTLATRFQIRLDPALRAALATRLPAVLG
>Mature_292_residues
MLAADEIPALHPDQLVAWLRRIGIAEVPDAPTLPVLNTLIAAQLAHIPFENLDALLGRRVSIDLPSVFEKLVAQGRGGYC
FEQNTLLCAGLKALGYAVTPLAARVRWHVPEATPTGLSHMLLRVEVAHESYIADVGFGGPTPDRALSLSLPPDENTPYRL
HPSPANALTGTGFHCLDLTVPDVSDDASGWQPIYRFDLTPQPWIDFIARNWYVSTHPDSHFTRTLMAARTDGDTRLALAN
GNLSERSPDGSVRKTALASADAVIDTLATRFQIRLDPALRAALATRLPAVLG

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=283, Percent_Identity=27.5618374558304, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI237649130, Length=283, Percent_Identity=27.5618374558304, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI237649128, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI237649126, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI237649124, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI237649122, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI237649119, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI42741671, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI237649009, Length=283, Percent_Identity=27.208480565371, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI116295260, Length=228, Percent_Identity=26.7543859649123, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787736, Length=264, Percent_Identity=34.0909090909091, Blast_Score=111, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 31626; Mature: 31626

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAADEIPALHPDQLVAWLRRIGIAEVPDAPTLPVLNTLIAAQLAHIPFENLDALLGRRV
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEE
SIDLPSVFEKLVAQGRGGYCFEQNTLLCAGLKALGYAVTPLAARVRWHVPEATPTGLSHM
EECHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHH
LLRVEVAHESYIADVGFGGPTPDRALSLSLPPDENTPYRLHPSPANALTGTGFHCLDLTV
HHHEEEHHHHHEEECCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEEEEEEC
PDVSDDASGWQPIYRFDLTPQPWIDFIARNWYVSTHPDSHFTRTLMAARTDGDTRLALAN
CCCCCCCCCCCCEEEECCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHCCCCCEEEEEEC
GNLSERSPDGSVRKTALASADAVIDTLATRFQIRLDPALRAALATRLPAVLG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAADEIPALHPDQLVAWLRRIGIAEVPDAPTLPVLNTLIAAQLAHIPFENLDALLGRRV
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEE
SIDLPSVFEKLVAQGRGGYCFEQNTLLCAGLKALGYAVTPLAARVRWHVPEATPTGLSHM
EECHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHH
LLRVEVAHESYIADVGFGGPTPDRALSLSLPPDENTPYRLHPSPANALTGTGFHCLDLTV
HHHEEEHHHHHEEECCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEEEEEEC
PDVSDDASGWQPIYRFDLTPQPWIDFIARNWYVSTHPDSHFTRTLMAARTDGDTRLALAN
CCCCCCCCCCCCEEEECCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHCCCCCEEEEEEC
GNLSERSPDGSVRKTALASADAVIDTLATRFQIRLDPALRAALATRLPAVLG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]