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The map label for this gene is upp [H]

Identifier: 94313492

GI number: 94313492

Start: 1183201

End: 1183818

Strand: Reverse

Name: upp [H]

Synonym: Rmet_4570

Alternate gene names: 94313492

Gene position: 1183818-1183201 (Counterclockwise)

Preceding gene: 94313493

Following gene: 94313491

Centisome position: 45.88

GC content: 62.62

Gene sequence:

>618_bases
ATGGTCGTGAATCATCCACTGGTGCAGCACAAGGTCACACTCGTGCGCAACGAGGACACCACCACCGACAACTTCCGGCG
CCTGGTGCGGGAGATCAGCCAGCTCCTGACCTACGAGGCGACGCGCGACCTGGCGATGGAGATCATCTCGATCCGCACGC
CGATCGCGCCCATGCAGTCGCCGGTGCTGTCCGGCAAGAAGCTCTGTCTGGTATCGATCCTCCGTGCCGGCAACGGCTTT
CTCGACGGGATGCTGGAACTGCTGCCGGCTGCTCGCGTGGGTCATATCGGCCTGTACCGCGACCCCGAGACACTGGAGCC
GATCGAGTACTACTTCAAGATGCCCGAGGACATCGGCGAGCGGATGGTGATCGTCGTCGACCCGATGCTGGCTACGGGCA
ACTCGGCCATCGCCGCATTGAATCGTCTCAAGGAAGCGGGGGTGACCACCATGAAGTATGTCTGCCTGATTGCATCGCGG
CCCGGATTACGCGCGCTGCAGGCAGCGCACCCTGATGTCTGCATCGTCACGGCGGCCATTGACGAGCAACTCAACGAGCA
CGGCTATATCGTGCCCGGTCTCGGCGATGCCGGTGACCGGCTCTACGGCACCAAATGA

Upstream 100 bases:

>100_bases
GAGTTTGTCACTCAAGGAGCGCACCATGAACGATCTGCCAGCCGCGGCTGCGGCCACGGAGACCTATGTCAACCCCGATA
AGGCCACGTCGCCTTCGGTC

Downstream 100 bases:

>100_bases
TGGGCGCGCCGGCGCTTGCGCCGCCCGTGCGCGAATCGGGAGGCCGTATCCGGCAGGAGAATGAGGCGCAGATCCTGCGC
GCCGCGGAACACGTGTTCGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MVVNHPLVQHKVTLVRNEDTTTDNFRRLVREISQLLTYEATRDLAMEIISIRTPIAPMQSPVLSGKKLCLVSILRAGNGF
LDGMLELLPAARVGHIGLYRDPETLEPIEYYFKMPEDIGERMVIVVDPMLATGNSAIAALNRLKEAGVTTMKYVCLIASR
PGLRALQAAHPDVCIVTAAIDEQLNEHGYIVPGLGDAGDRLYGTK

Sequences:

>Translated_205_residues
MVVNHPLVQHKVTLVRNEDTTTDNFRRLVREISQLLTYEATRDLAMEIISIRTPIAPMQSPVLSGKKLCLVSILRAGNGF
LDGMLELLPAARVGHIGLYRDPETLEPIEYYFKMPEDIGERMVIVVDPMLATGNSAIAALNRLKEAGVTTMKYVCLIASR
PGLRALQAAHPDVCIVTAAIDEQLNEHGYIVPGLGDAGDRLYGTK
>Mature_205_residues
MVVNHPLVQHKVTLVRNEDTTTDNFRRLVREISQLLTYEATRDLAMEIISIRTPIAPMQSPVLSGKKLCLVSILRAGNGF
LDGMLELLPAARVGHIGLYRDPETLEPIEYYFKMPEDIGERMVIVVDPMLATGNSAIAALNRLKEAGVTTMKYVCLIASR
PGLRALQAAHPDVCIVTAAIDEQLNEHGYIVPGLGDAGDRLYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.1980198019802, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.1980198019802, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.6470588235294, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=52.2167487684729, Blast_Score=228, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=29.126213592233, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=29.126213592233, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=41.1458333333333, Blast_Score=132, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=30.5825242718447, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=30.5825242718447, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=30.5825242718447, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=30.5825242718447, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21358379, Length=137, Percent_Identity=29.1970802919708, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22551; Mature: 22551

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVNHPLVQHKVTLVRNEDTTTDNFRRLVREISQLLTYEATRDLAMEIISIRTPIAPMQS
CCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PVLSGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGLYRDPETLEPIEYYFKMPEDIGE
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHCC
RMVIVVDPMLATGNSAIAALNRLKEAGVTTMKYVCLIASRPGLRALQAAHPDVCIVTAAI
EEEEEECCCHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCCEEEEEHHH
DEQLNEHGYIVPGLGDAGDRLYGTK
HHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVVNHPLVQHKVTLVRNEDTTTDNFRRLVREISQLLTYEATRDLAMEIISIRTPIAPMQS
CCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PVLSGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGLYRDPETLEPIEYYFKMPEDIGE
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHCC
RMVIVVDPMLATGNSAIAALNRLKEAGVTTMKYVCLIASRPGLRALQAAHPDVCIVTAAI
EEEEEECCCHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCCEEEEEHHH
DEQLNEHGYIVPGLGDAGDRLYGTK
HHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA