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The map label for this gene is soxR [H]

Identifier: 94313463

GI number: 94313463

Start: 1145681

End: 1146190

Strand: Reverse

Name: soxR [H]

Synonym: Rmet_4538

Alternate gene names: 94313463

Gene position: 1146190-1145681 (Counterclockwise)

Preceding gene: 94313466

Following gene: 94313461

Centisome position: 44.42

GC content: 65.88

Gene sequence:

>510_bases
ATGAAACGCGCCCTCGAAGATCAGGAAGACCACCCGTTGCGATCCGGCGATCCGCTCACCGTTGGTGAAGTTGCCGCGCG
TAGCGGCGTCGCGGTGTCCGCGCTGCATTTCTATGAATCGAAGGGATTGATCTGCAGCACACGAAGTGCCGGCAACCAGC
GCCGGTATCCGCGCGGGATACTGCGGCGCCTTGCGGTCATACGGGTGGCCCAGCGCATGGGCTTGCCGCTGTCCGTGATT
GCCGAAGCGTTCAGCCGCCTGCCGGATGACAAGGCGCCGACGGTTGCGGATTGGCGGCGGCTCTCGGCCGTATGGCGCGC
GGATCTGGACGCGCGCATCCGCACGCTGACCCAACTCCGCGATCAGCTCGATGGCTGTATCGGATGCGGGTGTCTGTCCC
TGAAGGAATGTCCGTTGCGCAATCCGCAGGACGCGCTGGCGGAAGAAGGGCCCGGCCCGCATTTCGGGGCCGGGCCCTGT
GAGCACCGGAAATCGGGCAAGGCGCGATGA

Upstream 100 bases:

>100_bases
CGCGCCAGTATCAAACCTCAAGCACGCTTGAGGTCAAGCTGTTTGTTGGCGAGTTTTCACGCTACGATGGCGCATCGTCC
GTGACCAGCTTTCCACCACC

Downstream 100 bases:

>100_bases
CCAGCGCGGCGATGGAGCCGCCGGTCAGGGCGCCACGATCACCCGGGTGCGAATGAAGGCGTCATCCTTCATCAGCGCCT
CCGCCCAGCCGGCAGGCGGC

Product: transcriptional activator for superoxide response; Fe-S center for redox-sensing (MerR family)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MKRALEDQEDHPLRSGDPLTVGEVAARSGVAVSALHFYESKGLICSTRSAGNQRRYPRGILRRLAVIRVAQRMGLPLSVI
AEAFSRLPDDKAPTVADWRRLSAVWRADLDARIRTLTQLRDQLDGCIGCGCLSLKECPLRNPQDALAEEGPGPHFGAGPC
EHRKSGKAR

Sequences:

>Translated_169_residues
MKRALEDQEDHPLRSGDPLTVGEVAARSGVAVSALHFYESKGLICSTRSAGNQRRYPRGILRRLAVIRVAQRMGLPLSVI
AEAFSRLPDDKAPTVADWRRLSAVWRADLDARIRTLTQLRDQLDGCIGCGCLSLKECPLRNPQDALAEEGPGPHFGAGPC
EHRKSGKAR
>Mature_169_residues
MKRALEDQEDHPLRSGDPLTVGEVAARSGVAVSALHFYESKGLICSTRSAGNQRRYPRGILRRLAVIRVAQRMGLPLSVI
AEAFSRLPDDKAPTVADWRRLSAVWRADLDARIRTLTQLRDQLDGCIGCGCLSLKECPLRNPQDALAEEGPGPHFGAGPC
EHRKSGKAR

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=134, Percent_Identity=64.1791044776119, Blast_Score=183, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 18521; Mature: 18521

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRALEDQEDHPLRSGDPLTVGEVAARSGVAVSALHFYESKGLICSTRSAGNQRRYPRGI
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCCCCHHHH
LRRLAVIRVAQRMGLPLSVIAEAFSRLPDDKAPTVADWRRLSAVWRADLDARIRTLTQLR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQLDGCIGCGCLSLKECPLRNPQDALAEEGPGPHFGAGPCEHRKSGKAR
HHHHHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKRALEDQEDHPLRSGDPLTVGEVAARSGVAVSALHFYESKGLICSTRSAGNQRRYPRGI
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCCCCHHHH
LRRLAVIRVAQRMGLPLSVIAEAFSRLPDDKAPTVADWRRLSAVWRADLDARIRTLTQLR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQLDGCIGCGCLSLKECPLRNPQDALAEEGPGPHFGAGPCEHRKSGKAR
HHHHHHHHCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9045804; 10984043 [H]