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The map label for this gene is czcS2 [H]

Identifier: 94313391

GI number: 94313391

Start: 1062336

End: 1063778

Strand: Direct

Name: czcS2 [H]

Synonym: Rmet_4466

Alternate gene names: 94313391

Gene position: 1062336-1063778 (Clockwise)

Preceding gene: 94313390

Following gene: 94313392

Centisome position: 41.17

GC content: 66.04

Gene sequence:

>1443_bases
ATGCGGTTGCTGTCGAAGCTGCAGGCCGCAATGCCGGCATCGCTTACCACGCGGCTGGCGCTGGCCTATGGGCTGACCAC
GGCGGCGGTGCTGGTTGGCGTGGCAACGTATCTGTCGAGTTCGCTGGGTAACCAGTTGCAGGCGCGCGATGAAGGCGAGC
TGGTAGGCGAGGTGCTGCTGGTGCGGCATCTGCTGCGTGAAGTTGGCAGTGAGGCCGAAATTCGCGCGGACACACACCGA
TTTGCCGATATCGCCATGGGGCACGAAGGGCTGGTGCTCGTGGTCCGCACGTTGGGCGGCGATCCGCTGGTCACGCTCAA
CCCGCGTAATGAACGGGTTCCAGATCTGCGCGTGCTGCCGCTCGCCACGGCGCCCGATACGACCCAATTGCAGACCTGGT
ATCCACGCAATGGCGTGCCGTCACGCGGCATCGTCGCGTTGGGCCAGATTGGCGACTCCGGTCAGACTGTGGAGATCGTC
GTGCTCAGCGATGCGGGCTATCGCGTGGCGCTGATGCGCGAGTATCACAGCCGGTTGCTCGTGGCGGTGCTGTGCGGTGC
GATCGTGGCGGCGGCCCTCGGTTTCCTGCTGGCACGGCGTGGCTTGCGGCCCTTGCGGCGGATGGCGAGCGATGCGGCGG
CCGTGACCACGAGCCGACTGGCGACGCGCCTCGACGTAGGCAGCGCACCGGAGGAATTGCGCGATCTGGCGGGCGCGTTC
AACGGTATGCTCGCGCGCCTGCAGGACAGCTTCACGCGGCTTTCCACGTTCTCGGCCGATCTGGCGCACGACTTCCGCAC
GCCGATCAGTAACCTCGTGGGCCAGACGCAGGTCACGCTGGCCCAGCGACGCACGGCGGCGGAGTATGAATCGTTGCTTG
AGTCGAATCTCGAGGAGTACGAGCGCTTGTCGCGCATGATCGAAAACATGCTGTTCCTGGCGCGCGCCGACAACGCACAG
GTTGCACTCGGGGCGCGGCCACTCGATGCGCGGGCGGAACTGGACAAGGTGGCGGAGTATTTCGAAGCTGTGGCCGCCGA
CCGCGACCTGACGCTGTCCGTCACCGGCGCGGCCACGGTGACTGCGGACCAGCCGTTGCTGCGGCGCGCCATCATCAATC
TGCTGGACAACGCGCTGCGTCACGCGCCTGCGGGCAGTACGGTGCAATTGGCCGTGTCACGTGGACAGCCCGGCCATACC
GCCATCAGCGTGGTGAACGGCGGCCCCGGGATCACGCCGGAGGCGCTGCCGCACCTTTTCGCACGCTTCTATCGCGGCGA
TCCGTCACGTCGCGACTCGGCCAAATCCACCGGCCTCGGCCTTGCCATTGTCGACACCATCATGCGGCTGCATGGCGGCA
GCGTGTCCGTGCGCAGCGTGGACGGACAAACCACGTTCGAACTCGACTTTCCTGACAAAGCTGTCAGTAGGGCAGGCGCA
TAA

Upstream 100 bases:

>100_bases
TCCGACGCCTGCGTGCCAAGGTGGATGACCCGTTCCCGAACTAGCTGATCCATACCCGCCGCGGCATGGGCTACGTGCTC
GACGAATTCGACGAGGCATG

Downstream 100 bases:

>100_bases
TAGTCGGCTCGCGGGATATGCCCGCTCCACGTAAGGAGACCGACATGCAGGTGCAACCGTATCTCGATTTTGGCGGCCGA
TTTGACGAGGCAATGGCGTT

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MRLLSKLQAAMPASLTTRLALAYGLTTAAVLVGVATYLSSSLGNQLQARDEGELVGEVLLVRHLLREVGSEAEIRADTHR
FADIAMGHEGLVLVVRTLGGDPLVTLNPRNERVPDLRVLPLATAPDTTQLQTWYPRNGVPSRGIVALGQIGDSGQTVEIV
VLSDAGYRVALMREYHSRLLVAVLCGAIVAAALGFLLARRGLRPLRRMASDAAAVTTSRLATRLDVGSAPEELRDLAGAF
NGMLARLQDSFTRLSTFSADLAHDFRTPISNLVGQTQVTLAQRRTAAEYESLLESNLEEYERLSRMIENMLFLARADNAQ
VALGARPLDARAELDKVAEYFEAVAADRDLTLSVTGAATVTADQPLLRRAIINLLDNALRHAPAGSTVQLAVSRGQPGHT
AISVVNGGPGITPEALPHLFARFYRGDPSRRDSAKSTGLGLAIVDTIMRLHGGSVSVRSVDGQTTFELDFPDKAVSRAGA

Sequences:

>Translated_480_residues
MRLLSKLQAAMPASLTTRLALAYGLTTAAVLVGVATYLSSSLGNQLQARDEGELVGEVLLVRHLLREVGSEAEIRADTHR
FADIAMGHEGLVLVVRTLGGDPLVTLNPRNERVPDLRVLPLATAPDTTQLQTWYPRNGVPSRGIVALGQIGDSGQTVEIV
VLSDAGYRVALMREYHSRLLVAVLCGAIVAAALGFLLARRGLRPLRRMASDAAAVTTSRLATRLDVGSAPEELRDLAGAF
NGMLARLQDSFTRLSTFSADLAHDFRTPISNLVGQTQVTLAQRRTAAEYESLLESNLEEYERLSRMIENMLFLARADNAQ
VALGARPLDARAELDKVAEYFEAVAADRDLTLSVTGAATVTADQPLLRRAIINLLDNALRHAPAGSTVQLAVSRGQPGHT
AISVVNGGPGITPEALPHLFARFYRGDPSRRDSAKSTGLGLAIVDTIMRLHGGSVSVRSVDGQTTFELDFPDKAVSRAGA
>Mature_480_residues
MRLLSKLQAAMPASLTTRLALAYGLTTAAVLVGVATYLSSSLGNQLQARDEGELVGEVLLVRHLLREVGSEAEIRADTHR
FADIAMGHEGLVLVVRTLGGDPLVTLNPRNERVPDLRVLPLATAPDTTQLQTWYPRNGVPSRGIVALGQIGDSGQTVEIV
VLSDAGYRVALMREYHSRLLVAVLCGAIVAAALGFLLARRGLRPLRRMASDAAAVTTSRLATRLDVGSAPEELRDLAGAF
NGMLARLQDSFTRLSTFSADLAHDFRTPISNLVGQTQVTLAQRRTAAEYESLLESNLEEYERLSRMIENMLFLARADNAQ
VALGARPLDARAELDKVAEYFEAVAADRDLTLSVTGAATVTADQPLLRRAIINLLDNALRHAPAGSTVQLAVSRGQPGHT
AISVVNGGPGITPEALPHLFARFYRGDPSRRDSAKSTGLGLAIVDTIMRLHGGSVSVRSVDGQTTFELDFPDKAVSRAGA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=40.5844155844156, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1788279, Length=464, Percent_Identity=29.9568965517241, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=29.0178571428571, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=257, Percent_Identity=29.9610894941634, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789403, Length=478, Percent_Identity=26.1506276150628, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=28.6821705426357, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=30.4964539007092, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787894, Length=311, Percent_Identity=28.6173633440514, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789808, Length=276, Percent_Identity=30.0724637681159, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=26.027397260274, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=26.8085106382979, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=301, Percent_Identity=26.9102990033223, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=26.8181818181818, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=26.1261261261261, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51404; Mature: 51404

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLSKLQAAMPASLTTRLALAYGLTTAAVLVGVATYLSSSLGNQLQARDEGELVGEVLL
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHH
VRHLLREVGSEAEIRADTHRFADIAMGHEGLVLVVRTLGGDPLVTLNPRNERVPDLRVLP
HHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEE
LATAPDTTQLQTWYPRNGVPSRGIVALGQIGDSGQTVEIVVLSDAGYRVALMREYHSRLL
ECCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
VAVLCGAIVAAALGFLLARRGLRPLRRMASDAAAVTTSRLATRLDVGSAPEELRDLAGAF
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NGMLARLQDSFTRLSTFSADLAHDFRTPISNLVGQTQVTLAQRRTAAEYESLLESNLEEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERLSRMIENMLFLARADNAQVALGARPLDARAELDKVAEYFEAVAADRDLTLSVTGAATV
HHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCEEE
TADQPLLRRAIINLLDNALRHAPAGSTVQLAVSRGQPGHTAISVVNGGPGITPEALPHLF
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHH
ARFYRGDPSRRDSAKSTGLGLAIVDTIMRLHGGSVSVRSVDGQTTFELDFPDKAVSRAGA
HHHHCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCHHHHHCCCC
>Mature Secondary Structure
MRLLSKLQAAMPASLTTRLALAYGLTTAAVLVGVATYLSSSLGNQLQARDEGELVGEVLL
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHH
VRHLLREVGSEAEIRADTHRFADIAMGHEGLVLVVRTLGGDPLVTLNPRNERVPDLRVLP
HHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEE
LATAPDTTQLQTWYPRNGVPSRGIVALGQIGDSGQTVEIVVLSDAGYRVALMREYHSRLL
ECCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
VAVLCGAIVAAALGFLLARRGLRPLRRMASDAAAVTTSRLATRLDVGSAPEELRDLAGAF
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NGMLARLQDSFTRLSTFSADLAHDFRTPISNLVGQTQVTLAQRRTAAEYESLLESNLEEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERLSRMIENMLFLARADNAQVALGARPLDARAELDKVAEYFEAVAADRDLTLSVTGAATV
HHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCEEE
TADQPLLRRAIINLLDNALRHAPAGSTVQLAVSRGQPGHTAISVVNGGPGITPEALPHLF
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHH
ARFYRGDPSRRDSAKSTGLGLAIVDTIMRLHGGSVSVRSVDGQTTFELDFPDKAVSRAGA
HHHHCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]