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The map label for this gene is czcR2 [H]

Identifier: 94313390

GI number: 94313390

Start: 1061659

End: 1062279

Strand: Direct

Name: czcR2 [H]

Synonym: Rmet_4465

Alternate gene names: 94313390

Gene position: 1061659-1062279 (Clockwise)

Preceding gene: 94313388

Following gene: 94313391

Centisome position: 41.15

GC content: 63.77

Gene sequence:

>621_bases
ATGCGCATCCTGATTGTCGAAGACGAGCCGAAGGCCGGTGATTATCTGCTCAAGGGACTCACCGAGTCGGGCTTCGTGGC
CGATCTGGCCCGCGACGGCGTGGATGGGCTGGCCCACGCACGCGAGCAGCACTATGACCTGATCGTGCTCGACGTGATGC
TGCCCGGCATGGATGGCTGGCAGGTATTGCGCGAACTGCGCCGGGACAAGGACACGCCCGTGCTGTGCCTGACCGCGCGT
GACGAATTGTCCGATCGGCTCAAGGGGCTGGAACTGGGCGCAGACGACTACATGGTCAAGCCGTTCGCTTTTGCCGAACT
GGTGGCGCGTATCCGGACGATCCTGCGGCGTGGCCCGCTGCGCGAGAGCGAATTCATCGAGGTGGCCGACCTGCAGATCG
ACACCATCCGCCGCCGCGTGACCCGCGCGGGGCAGAAAATCGACCTCACCTCGAAGGAGTTCGCGCTGCTGCAATTGCTG
GCGCGGCGCCGTGGCGAGGTATTGTCACGCTCGCTGATTGCGTCGCAGGTCTGGGATATGAACTTCGACAGCAACACCAA
CGTCGTGGACGTGTCGATCCGACGCCTGCGTGCCAAGGTGGATGACCCGTTCCCGAACTAG

Upstream 100 bases:

>100_bases
AATGTTCGCCAATTCGTGGCAAAGCTCCGCTAGTGTCTCGGTCTATATCCAGAACCTCGAATAATGGGCCGGTACCAAGC
CGGCTTGGAAGTGAACCAAC

Downstream 100 bases:

>100_bases
CTGATCCATACCCGCCGCGGCATGGGCTACGTGCTCGACGAATTCGACGAGGCATGATGCGGTTGCTGTCGAAGCTGCAG
GCCGCAATGCCGGCATCGCT

Product: two component heavy metal response transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRILIVEDEPKAGDYLLKGLTESGFVADLARDGVDGLAHAREQHYDLIVLDVMLPGMDGWQVLRELRRDKDTPVLCLTAR
DELSDRLKGLELGADDYMVKPFAFAELVARIRTILRRGPLRESEFIEVADLQIDTIRRRVTRAGQKIDLTSKEFALLQLL
ARRRGEVLSRSLIASQVWDMNFDSNTNVVDVSIRRLRAKVDDPFPN

Sequences:

>Translated_206_residues
MRILIVEDEPKAGDYLLKGLTESGFVADLARDGVDGLAHAREQHYDLIVLDVMLPGMDGWQVLRELRRDKDTPVLCLTAR
DELSDRLKGLELGADDYMVKPFAFAELVARIRTILRRGPLRESEFIEVADLQIDTIRRRVTRAGQKIDLTSKEFALLQLL
ARRRGEVLSRSLIASQVWDMNFDSNTNVVDVSIRRLRAKVDDPFPN
>Mature_206_residues
MRILIVEDEPKAGDYLLKGLTESGFVADLARDGVDGLAHAREQHYDLIVLDVMLPGMDGWQVLRELRRDKDTPVLCLTAR
DELSDRLKGLELGADDYMVKPFAFAELVARIRTILRRGPLRESEFIEVADLQIDTIRRRVTRAGQKIDLTSKEFALLQLL
ARRRGEVLSRSLIASQVWDMNFDSNTNVVDVSIRRLRAKVDDPFPN

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=207, Percent_Identity=60.3864734299517, Blast_Score=253, Evalue=8e-69,
Organism=Escherichia coli, GI87082012, Length=205, Percent_Identity=54.1463414634146, Blast_Score=233, Evalue=5e-63,
Organism=Escherichia coli, GI1789402, Length=205, Percent_Identity=41.9512195121951, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1788394, Length=202, Percent_Identity=42.0792079207921, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790552, Length=206, Percent_Identity=42.7184466019417, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1786599, Length=204, Percent_Identity=39.7058823529412, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1790860, Length=201, Percent_Identity=37.8109452736318, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786911, Length=204, Percent_Identity=35.7843137254902, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=207, Percent_Identity=31.4009661835749, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789809, Length=216, Percent_Identity=35.1851851851852, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=209, Percent_Identity=39.7129186602871, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=207, Percent_Identity=32.3671497584541, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=209, Percent_Identity=30.622009569378, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI145693140, Length=212, Percent_Identity=29.7169811320755, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=37.1428571428571, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=34.2105263157895, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 23459; Mature: 23459

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDEPKAGDYLLKGLTESGFVADLARDGVDGLAHAREQHYDLIVLDVMLPGMDGW
CEEEEEECCCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCCCHH
QVLRELRRDKDTPVLCLTARDELSDRLKGLELGADDYMVKPFAFAELVARIRTILRRGPL
HHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCC
RESEFIEVADLQIDTIRRRVTRAGQKIDLTSKEFALLQLLARRRGEVLSRSLIASQVWDM
CCCCCHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSNTNVVDVSIRRLRAKVDDPFPN
CCCCCCCEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRILIVEDEPKAGDYLLKGLTESGFVADLARDGVDGLAHAREQHYDLIVLDVMLPGMDGW
CEEEEEECCCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCCCHH
QVLRELRRDKDTPVLCLTARDELSDRLKGLELGADDYMVKPFAFAELVARIRTILRRGPL
HHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCC
RESEFIEVADLQIDTIRRRVTRAGQKIDLTSKEFALLQLLARRRGEVLSRSLIASQVWDM
CCCCCHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSNTNVVDVSIRRLRAKVDDPFPN
CCCCCCCEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]