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The map label for this gene is Hgd [H]

Identifier: 94313356

GI number: 94313356

Start: 1026927

End: 1027808

Strand: Direct

Name: Hgd [H]

Synonym: Rmet_4431

Alternate gene names: 94313356

Gene position: 1026927-1027808 (Clockwise)

Preceding gene: 94313355

Following gene: 94313358

Centisome position: 39.8

GC content: 65.31

Gene sequence:

>882_bases
ATGCAGGCAATCAAGACTATTGGATTTATCGGTGTTGGCGTCATGGGCGAGCCTATGTGCCGCCACCTGGCGCAGAAGAG
CGGAGCGACCGTCCTCGCGTGCGACCGCGATGCCGCGCCGCTGGCGCGTCTGGCCGAATGCGGCGTGCGCGCTGCGACGA
TGGCAGAGGTCTCTGCGCAGGCGGACATCGTCTTCCTGTCGCTGCCCTCTGGCGAGGTGGTCGAATCGGTGGTGCTGGGC
GAAAACGGCCTGCTGGCCGGTGGCCGCGCCGGTCAGATCATCGTCGACCTGAGCACGTCCACGATGAACACGGCACGCAA
GGCTGCGGAGGCCATGGCGGCCAGGGGCATGAAGTTTGCCGATGCGCCGGTCATGCGCACGCGTGCAGCGGCCGAAGCCG
GCACGCTGGCGGTGCCGGTGGGCGCTGACGACGCGCTGTTCGCGCTGGTTGCCCCGTTCATCCGCATGTTCGCCTCGGAT
GTCGTCCATGCCGGTGGCGTGGGCGCGGGGCAGGTCGTGAAGATCCTCAACAACATGGTGCTCTACGAGACCGTGCTCGC
ACTGTCTGAAGCGCGTGCGATCGGCGTGCGAGCCGGTCTTTCGCCGCAGGGGCTTTTCGAGGCGCTTTCCATTGGTTCGG
CCGACAGCTTCGCGCTGCGCAATCACGGCATGAAGGCGATTGCGCCCCAGGTCTTTCCGGAGCGCGCATTCCCGGTGACC
TACGCGCGCAAGGACATCAGCTATGCCGTAGCCCTGGCTGACCAATTGGGTGTGGAAGCCACTGGCGCGAAGAACCTGAT
GAACTGTCTCGATCAGGCCATCGAGGCTGGCCACGGCGACAAGTACGCACCGGCCATCAGCCTGGTATTCGAAGGCAAGT
AA

Upstream 100 bases:

>100_bases
AAGCAAAGGCATCTACTGGAGCATGGACGAGAAGAACTTCCCGTCCGACGGGGCCCTGGCCTGACGTCTACCAGTTTCCA
GATCAGGAGCGCATCAAATC

Downstream 100 bases:

>100_bases
CTCGGGGACGAAAGCGGCGGAAGTCGCTGGCGAGGGGGCTCTGGCCACGACGCAAAAACGTGGCCAGAGCGTGCCGATCA
GGCGCGGCGCTTCGCGGCTT

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MQAIKTIGFIGVGVMGEPMCRHLAQKSGATVLACDRDAAPLARLAECGVRAATMAEVSAQADIVFLSLPSGEVVESVVLG
ENGLLAGGRAGQIIVDLSTSTMNTARKAAEAMAARGMKFADAPVMRTRAAAEAGTLAVPVGADDALFALVAPFIRMFASD
VVHAGGVGAGQVVKILNNMVLYETVLALSEARAIGVRAGLSPQGLFEALSIGSADSFALRNHGMKAIAPQVFPERAFPVT
YARKDISYAVALADQLGVEATGAKNLMNCLDQAIEAGHGDKYAPAISLVFEGK

Sequences:

>Translated_293_residues
MQAIKTIGFIGVGVMGEPMCRHLAQKSGATVLACDRDAAPLARLAECGVRAATMAEVSAQADIVFLSLPSGEVVESVVLG
ENGLLAGGRAGQIIVDLSTSTMNTARKAAEAMAARGMKFADAPVMRTRAAAEAGTLAVPVGADDALFALVAPFIRMFASD
VVHAGGVGAGQVVKILNNMVLYETVLALSEARAIGVRAGLSPQGLFEALSIGSADSFALRNHGMKAIAPQVFPERAFPVT
YARKDISYAVALADQLGVEATGAKNLMNCLDQAIEAGHGDKYAPAISLVFEGK
>Mature_293_residues
MQAIKTIGFIGVGVMGEPMCRHLAQKSGATVLACDRDAAPLARLAECGVRAATMAEVSAQADIVFLSLPSGEVVESVVLG
ENGLLAGGRAGQIIVDLSTSTMNTARKAAEAMAARGMKFADAPVMRTRAAAEAGTLAVPVGADDALFALVAPFIRMFASD
VVHAGGVGAGQVVKILNNMVLYETVLALSEARAIGVRAGLSPQGLFEALSIGSADSFALRNHGMKAIAPQVFPERAFPVT
YARKDISYAVALADQLGVEATGAKNLMNCLDQAIEAGHGDKYAPAISLVFEGK

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=213, Percent_Identity=31.4553990610329, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI40556376, Length=251, Percent_Identity=28.6852589641434, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI145693186, Length=257, Percent_Identity=32.6848249027237, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786719, Length=250, Percent_Identity=31.6, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=30.6338028169014, Blast_Score=94, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17557316, Length=201, Percent_Identity=32.3383084577114, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655230, Length=216, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922568, Length=216, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574115, Length=254, Percent_Identity=22.0472440944882, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30187; Mature: 30187

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIKTIGFIGVGVMGEPMCRHLAQKSGATVLACDRDAAPLARLAECGVRAATMAEVSAQ
CCCHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHCCC
ADIVFLSLPSGEVVESVVLGENGLLAGGRAGQIIVDLSTSTMNTARKAAEAMAARGMKFA
CCEEEEECCCCHHHHHHHCCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCC
DAPVMRTRAAAEAGTLAVPVGADDALFALVAPFIRMFASDVVHAGGVGAGQVVKILNNMV
CCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LYETVLALSEARAIGVRAGLSPQGLFEALSIGSADSFALRNHGMKAIAPQVFPERAFPVT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCHHHCCCCCCCHH
YARKDISYAVALADQLGVEATGAKNLMNCLDQAIEAGHGDKYAPAISLVFEGK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MQAIKTIGFIGVGVMGEPMCRHLAQKSGATVLACDRDAAPLARLAECGVRAATMAEVSAQ
CCCHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHCCC
ADIVFLSLPSGEVVESVVLGENGLLAGGRAGQIIVDLSTSTMNTARKAAEAMAARGMKFA
CCEEEEECCCCHHHHHHHCCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCC
DAPVMRTRAAAEAGTLAVPVGADDALFALVAPFIRMFASDVVHAGGVGAGQVVKILNNMV
CCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LYETVLALSEARAIGVRAGLSPQGLFEALSIGSADSFALRNHGMKAIAPQVFPERAFPVT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCHHHCCCCCCCHH
YARKDISYAVALADQLGVEATGAKNLMNCLDQAIEAGHGDKYAPAISLVFEGK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA