Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 94313161

GI number: 94313161

Start: 819154

End: 820092

Strand: Direct

Name: serA [H]

Synonym: Rmet_4234

Alternate gene names: 94313161

Gene position: 819154-820092 (Clockwise)

Preceding gene: 94313160

Following gene: 94313162

Centisome position: 31.75

GC content: 62.09

Gene sequence:

>939_bases
GTGAAGAAGCAACCGGTGGTGCTGGTCACGGGCAATGATCTGGCACCCCAGGCACTCGAACTGCTCAAGGACTTCGAGGT
TCGTTTCGCCGGCAAATCGTGTACCGAAGACGTCTTGCTGGCACTGGCAAAGGAGACCGATCCTGTTGCCATCATCGTGC
GCTATGGCAGGATCGGCGCCAGCATCATGGATGCTGCGCCGTCGCTGAAGGTGATCTCGAAGCATGGCAGCGGTATCGAC
GTAATCGACCAGAAGGCCGCAGCCGAACGCGGCATCGCAGTGAAGGCCGCGGTTGGTGCCAATGCCGCCGCCGTTGCTGA
GCACGCTTGGGCGCTGATTCTGGCCTGTGCCAAGTCCGTGCCGCATCTGAACGACCGCATGCGTGAGGGCTATTGGGACA
AATCGATCCATAAGAGCATCGAACTGAACGGCCGCACGCTGGGTATCGTCGGTCTTGGCGAAATCGGTCGCCGCGTAGCG
GTGACCGGTGTGGTGTTGGGTATGCGCGTGATCGCATTCGACCCCTATGCGAATGCAGCGCCGGATGGCGTCGAGCTAGT
CAACGATCTGCACGATATCTACCGGAATGCGGATGTGGTGTCGCTGCATTGCCCGCTGACGGAGAGCAATCGCGGCATGC
TGCATCGCGAGACGCTGGGCCTATTCAAGAACGGCGCGATCCTGATTAATACCGCACGCGGTGGCCTGGTCGACGAACCG
GCATTGGCCGAGGCCCTCACGAACGGCATGCTCTATGCGGCTGGCCTGGACAGCTTCGCGGTCGAGCCGATGACCGCCCC
GCATCCGCTCCAGCAGATCCCGAACGCCATCCTGACGCCGCACATTGGCGGCGTCAGCGATGCGGCCTACGTGAGCATGG
GCGTAGGCGCGGCAACGAATGTGCTGGCTGTGCTGGGCAGCGTCACGGCAGATGGCTGA

Upstream 100 bases:

>100_bases
AGCGCATCGCTGCCATCAAGGCTGGCGATCTGCGACCGGGCTGGCTCGACAAGGAACTGCGTGCAGCTGGCGTGCTGGCC
GAAGGCGAATCGCTGTGAGC

Downstream 100 bases:

>100_bases
CTTCGGGGTACGGAGTTTGCTGACCTGACTGTAGCCGACGCTACACGAGGCGCTGGGATCATTCTCCGATGCTGGCACCT
GCCGGCCGCAAGGTGCTAAT

Product: putative D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKKQPVVLVTGNDLAPQALELLKDFEVRFAGKSCTEDVLLALAKETDPVAIIVRYGRIGASIMDAAPSLKVISKHGSGID
VIDQKAAAERGIAVKAAVGANAAAVAEHAWALILACAKSVPHLNDRMREGYWDKSIHKSIELNGRTLGIVGLGEIGRRVA
VTGVVLGMRVIAFDPYANAAPDGVELVNDLHDIYRNADVVSLHCPLTESNRGMLHRETLGLFKNGAILINTARGGLVDEP
ALAEALTNGMLYAAGLDSFAVEPMTAPHPLQQIPNAILTPHIGGVSDAAYVSMGVGAATNVLAVLGSVTADG

Sequences:

>Translated_312_residues
MKKQPVVLVTGNDLAPQALELLKDFEVRFAGKSCTEDVLLALAKETDPVAIIVRYGRIGASIMDAAPSLKVISKHGSGID
VIDQKAAAERGIAVKAAVGANAAAVAEHAWALILACAKSVPHLNDRMREGYWDKSIHKSIELNGRTLGIVGLGEIGRRVA
VTGVVLGMRVIAFDPYANAAPDGVELVNDLHDIYRNADVVSLHCPLTESNRGMLHRETLGLFKNGAILINTARGGLVDEP
ALAEALTNGMLYAAGLDSFAVEPMTAPHPLQQIPNAILTPHIGGVSDAAYVSMGVGAATNVLAVLGSVTADG
>Mature_312_residues
MKKQPVVLVTGNDLAPQALELLKDFEVRFAGKSCTEDVLLALAKETDPVAIIVRYGRIGASIMDAAPSLKVISKHGSGID
VIDQKAAAERGIAVKAAVGANAAAVAEHAWALILACAKSVPHLNDRMREGYWDKSIHKSIELNGRTLGIVGLGEIGRRVA
VTGVVLGMRVIAFDPYANAAPDGVELVNDLHDIYRNADVVSLHCPLTESNRGMLHRETLGLFKNGAILINTARGGLVDEP
ALAEALTNGMLYAAGLDSFAVEPMTAPHPLQQIPNAILTPHIGGVSDAAYVSMGVGAATNVLAVLGSVTADG

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI61743967, Length=308, Percent_Identity=33.1168831168831, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI145580578, Length=308, Percent_Identity=34.7402597402597, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI4557499, Length=308, Percent_Identity=34.7402597402597, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI4557497, Length=308, Percent_Identity=33.1168831168831, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=38.7755102040816, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=29.5719844357977, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1789279, Length=246, Percent_Identity=36.5853658536585, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787645, Length=208, Percent_Identity=35.0961538461538, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI87082289, Length=254, Percent_Identity=30.7086614173228, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788660, Length=253, Percent_Identity=29.6442687747036, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=33.6601307189542, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=332, Percent_Identity=29.8192771084337, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=296, Percent_Identity=31.0810810810811, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=287, Percent_Identity=30.3135888501742, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=245, Percent_Identity=30.6122448979592, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=307, Percent_Identity=29.6416938110749, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=173, Percent_Identity=28.3236994219653, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921140, Length=264, Percent_Identity=34.469696969697, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646446, Length=261, Percent_Identity=37.9310344827586, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646448, Length=261, Percent_Identity=37.9310344827586, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646452, Length=261, Percent_Identity=37.9310344827586, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646450, Length=261, Percent_Identity=37.9310344827586, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI62472511, Length=261, Percent_Identity=37.9310344827586, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=30.5882352941176, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571528, Length=333, Percent_Identity=30.03003003003, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574286, Length=314, Percent_Identity=26.1146496815287, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=27.1653543307087, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=27.1653543307087, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=27.1653543307087, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=27.1653543307087, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=27.1653543307087, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32629; Mature: 32629

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQPVVLVTGNDLAPQALELLKDFEVRFAGKSCTEDVLLALAKETDPVAIIVRYGRIGA
CCCCCEEEEECCCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCH
SIMDAAPSLKVISKHGSGIDVIDQKAAAERGIAVKAAVGANAAAVAEHAWALILACAKSV
HHHHCCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
PHLNDRMREGYWDKSIHKSIELNGRTLGIVGLGEIGRRVAVTGVVLGMRVIAFDPYANAA
CCHHHHHHCCCCCHHHHHHEEECCEEEEEEEHHHHCCHHHHHHHHHHHEEEEECCCCCCC
PDGVELVNDLHDIYRNADVVSLHCPLTESNRGMLHRETLGLFKNGAILINTARGGLVDEP
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEHHHHHHHCCCEEEEECCCCCCCCCH
ALAEALTNGMLYAAGLDSFAVEPMTAPHPLQQIPNAILTPHIGGVSDAAYVSMGVGAATN
HHHHHHHCCEEEEECCCHHCCCCCCCCCHHHHCCHHHCCCCCCCCCCHHHHHHCCCHHHH
VLAVLGSVTADG
HHHHHHHHCCCC
>Mature Secondary Structure
MKKQPVVLVTGNDLAPQALELLKDFEVRFAGKSCTEDVLLALAKETDPVAIIVRYGRIGA
CCCCCEEEEECCCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCH
SIMDAAPSLKVISKHGSGIDVIDQKAAAERGIAVKAAVGANAAAVAEHAWALILACAKSV
HHHHCCCCCEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
PHLNDRMREGYWDKSIHKSIELNGRTLGIVGLGEIGRRVAVTGVVLGMRVIAFDPYANAA
CCHHHHHHCCCCCHHHHHHEEECCEEEEEEEHHHHCCHHHHHHHHHHHEEEEECCCCCCC
PDGVELVNDLHDIYRNADVVSLHCPLTESNRGMLHRETLGLFKNGAILINTARGGLVDEP
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEHHHHHHHCCCEEEEECCCCCCCCCH
ALAEALTNGMLYAAGLDSFAVEPMTAPHPLQQIPNAILTPHIGGVSDAAYVSMGVGAATN
HHHHHHHCCEEEEECCCHHCCCCCCCCCHHHHCCHHHCCCCCCCCCCHHHHHHCCCHHHH
VLAVLGSVTADG
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]