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The map label for this gene is crt [H]

Identifier: 94313152

GI number: 94313152

Start: 810609

End: 811412

Strand: Direct

Name: crt [H]

Synonym: Rmet_4225

Alternate gene names: 94313152

Gene position: 810609-811412 (Clockwise)

Preceding gene: 94313151

Following gene: 94313153

Centisome position: 31.42

GC content: 60.7

Gene sequence:

>804_bases
ATGAATCAGGAAACGGCAAAAATGGTGAACACGGAAGAGATCAAACATCTGTCACTCGATGTGTCGGAGCAAGGCGTGGC
GACACTGCGCATCGCCAATGGCACCAGTCTGAATATTCTGGACTCGGACACGATCGTCGAATTCACGCAAACGCTGCGTC
GGCTGGCTCGCCGCCCTGACGTCCGGGTACTGGTGTTGCGCGGGACGGGGGAGAAGGCATTCGTTGGTGGCGCGAACATC
AAGGAGCTGGCCAGGCTTGAGCCGGAGACGGCGGTGGCGTTCATCACGCGATTGCACGATCTGTGCGAGGCGGTCCGCGA
TTTCCCGGTGCCGACGATTGCTCGTTTGTCGGGCTGGTGCATGGGAGGCGGCATGGAGTTCGCCGCCGCTTGCGATATCC
GCATCGCTGACGAGAATGCCAATTTCGCCATGCCGGAAGTCAGGATCGGCATCCCGTCGGTCATTCATGCAAACATCCTT
TCTCGCCTGATCGGTGAGGGGAACACACGCTGGATGTTGCTGACTGGCTCCTCGATCAATGCGGCGCGCGCCCATGCCTG
GGGATTTGTCCACGAGGTCGTCGCCAACGACGCTCTGGATGCCGCAGTTGCGCATACGGTATCCGAGATACTGGAGTGCG
GGCCGGCAGCCGTGCGTGCGCAGAAGTCGCTGCTGCGCGCGTGGGAAGATCCTGCGATCGAGCGGGGGCTGAAGCACAGC
ATTGCGGTGTTTGGCGACGTCTACGCTGGGTCAGAACCGGATGCTTACATGGCGCGGTTCCTTGAGCGCAAGAGGAAAAG
CTGA

Upstream 100 bases:

>100_bases
GACAACGGCGTATCGTTTCTCGCTTTCGCTCGCCAGCCGCGCGAAATAATCTTGCAACGCCGGCGCCAATGCTTGGTCAG
TCGGCAGGGGAACTGGAAGA

Downstream 100 bases:

>100_bases
CAGGCGCTAGTAATCGGACGAAGCGGTCATGTACCATCGAACTGTCCATCCAATTGCCTGCGCCATGAACTTCACACTCA
GGGAGTTCCGAGTATTCCGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNQETAKMVNTEEIKHLSLDVSEQGVATLRIANGTSLNILDSDTIVEFTQTLRRLARRPDVRVLVLRGTGEKAFVGGANI
KELARLEPETAVAFITRLHDLCEAVRDFPVPTIARLSGWCMGGGMEFAAACDIRIADENANFAMPEVRIGIPSVIHANIL
SRLIGEGNTRWMLLTGSSINAARAHAWGFVHEVVANDALDAAVAHTVSEILECGPAAVRAQKSLLRAWEDPAIERGLKHS
IAVFGDVYAGSEPDAYMARFLERKRKS

Sequences:

>Translated_267_residues
MNQETAKMVNTEEIKHLSLDVSEQGVATLRIANGTSLNILDSDTIVEFTQTLRRLARRPDVRVLVLRGTGEKAFVGGANI
KELARLEPETAVAFITRLHDLCEAVRDFPVPTIARLSGWCMGGGMEFAAACDIRIADENANFAMPEVRIGIPSVIHANIL
SRLIGEGNTRWMLLTGSSINAARAHAWGFVHEVVANDALDAAVAHTVSEILECGPAAVRAQKSLLRAWEDPAIERGLKHS
IAVFGDVYAGSEPDAYMARFLERKRKS
>Mature_267_residues
MNQETAKMVNTEEIKHLSLDVSEQGVATLRIANGTSLNILDSDTIVEFTQTLRRLARRPDVRVLVLRGTGEKAFVGGANI
KELARLEPETAVAFITRLHDLCEAVRDFPVPTIARLSGWCMGGGMEFAAACDIRIADENANFAMPEVRIGIPSVIHANIL
SRLIGEGNTRWMLLTGSSINAARAHAWGFVHEVVANDALDAAVAHTVSEILECGPAAVRAQKSLLRAWEDPAIERGLKHS
IAVFGDVYAGSEPDAYMARFLERKRKS

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=243, Percent_Identity=29.6296296296296, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI20127408, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4502327, Length=223, Percent_Identity=27.3542600896861, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=207, Percent_Identity=27.0531400966184, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI213417737, Length=239, Percent_Identity=20.9205020920502, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI157694516, Length=239, Percent_Identity=20.9205020920502, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI31542718, Length=174, Percent_Identity=26.4367816091954, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787659, Length=243, Percent_Identity=27.5720164609054, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI221142681, Length=203, Percent_Identity=28.0788177339901, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=30.4812834224599, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082183, Length=208, Percent_Identity=29.3269230769231, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788597, Length=221, Percent_Identity=25.7918552036199, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788682, Length=209, Percent_Identity=28.2296650717703, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=202, Percent_Identity=28.7128712871287, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=242, Percent_Identity=28.5123966942149, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=217, Percent_Identity=26.2672811059908, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=190, Percent_Identity=32.1052631578947, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=158, Percent_Identity=24.6835443037975, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=227, Percent_Identity=29.0748898678414, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=227, Percent_Identity=29.0748898678414, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=227, Percent_Identity=29.0748898678414, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=176, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653139, Length=229, Percent_Identity=30.5676855895196, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20129971, Length=253, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24653477, Length=253, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922422, Length=190, Percent_Identity=25.7894736842105, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920382, Length=244, Percent_Identity=24.1803278688525, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 29128; Mature: 29128

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQETAKMVNTEEIKHLSLDVSEQGVATLRIANGTSLNILDSDTIVEFTQTLRRLARRPD
CCCHHHHHHCHHHHHHEECCCCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCC
VRVLVLRGTGEKAFVGGANIKELARLEPETAVAFITRLHDLCEAVRDFPVPTIARLSGWC
EEEEEEECCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEE
MGGGMEFAAACDIRIADENANFAMPEVRIGIPSVIHANILSRLIGEGNTRWMLLTGSSIN
CCCCCCEEEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
AARAHAWGFVHEVVANDALDAAVAHTVSEILECGPAAVRAQKSLLRAWEDPAIERGLKHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHH
IAVFGDVYAGSEPDAYMARFLERKRKS
HHHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQETAKMVNTEEIKHLSLDVSEQGVATLRIANGTSLNILDSDTIVEFTQTLRRLARRPD
CCCHHHHHHCHHHHHHEECCCCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCC
VRVLVLRGTGEKAFVGGANIKELARLEPETAVAFITRLHDLCEAVRDFPVPTIARLSGWC
EEEEEEECCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEE
MGGGMEFAAACDIRIADENANFAMPEVRIGIPSVIHANILSRLIGEGNTRWMLLTGSSIN
CCCCCCEEEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
AARAHAWGFVHEVVANDALDAAVAHTVSEILECGPAAVRAQKSLLRAWEDPAIERGLKHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHH
IAVFGDVYAGSEPDAYMARFLERKRKS
HHHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]