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The map label for this gene is mdtD [H]

Identifier: 94313104

GI number: 94313104

Start: 762833

End: 764242

Strand: Direct

Name: mdtD [H]

Synonym: Rmet_4177

Alternate gene names: 94313104

Gene position: 762833-764242 (Clockwise)

Preceding gene: 94313102

Following gene: 291481516

Centisome position: 29.57

GC content: 63.9

Gene sequence:

>1410_bases
TTGCCTATGCGTACCGCCTCTGCTTCCGCCACCGATCAGGCCTTCTCCCAGAAGGCCATGCTGTGGATCGTCTTCGCCGG
CTTTTTCATGCAGACGCTGGACACCACTATCGTCAACACCGCGCTGCCCGCCATGGCGCGCAGCCTGGGCGAGAAACCAC
TCGATCTCAAGCCTGTGGTGGTGGCCTACACGCTGACCATGGCGATGCTGACCCCGGCGTCTGGCTGGCTGGCCGACAGG
TTCGGCACACGGCGCGTCTACTTCAGCGCGATCCTGATCTTCGTGATTGGTTCGGTGTTCTGCGCCACGGCGCACACGCT
GACCCAACTGGTGATCGCGCGGGTGCTGCAAGGCATTGGCGGATCGATGCTGTTGCCGATCGGCAGGCTTGCGGTGCTGC
GCAACATACCCGGCGAGCAGTACATTGCCGCACTGGCCTTTGTCTCCATCGCGGGGCAGGTCGGGCCGATCTTTGGCCCG
GTGCTCGGCGGATGGCTGGTGCAGAGCGCGTCGTGGCACTGGATTTTCCTGATCAATGTCCCGGTGGGGCTGGTCGGCCT
GTTCGCCGTGCATCGTTACCTGCCGGCTGGCGAAGTGGATGCCGCGCCGCCGTTCGACTGGATAGGCTGTGGCCTGCTGT
CGCTGTGCATGGTCACGTTCTCGCTAGCGCTCGAGCGTGGTTCGGTCAGTAGCCTGAGTGCCGCGCTGATGGCCATAAGC
ATTGCCAGCGCGCTGCTCTACATTCCGCATGCGCGTCGCCATCGCACGCCGCTGTTCCGTCTCGCGCTGTTTCGGGAGCC
CAACTTCAGCGTGGGGCTGGTCGGCAATCTTGTCTGCCGCATCGGCTCGGGCGCCGTGCCGTTCCTGCTGCCGCTGCTGT
TTCAGCTCCAGCTAGGCTATTCACCCTTTCATTCGGGCCTGATGCTATTGCCGGTAGCGATTTCCGGGACCATCTCGAAG
CGCTGGATCGTGCCGCTGGTGAATCGCTTCGGCTACGACATATTCCTGCTCGTCAATACGGTGATCGTCGGGGCTTCGAT
CGCGTCGTTCGCGGCAATCTCGCCGGGCTGGCCGCTCGGGCTGTCGATCGTGCAGTTGGCGATCTTCGGCGCCGCCAACT
CCATGCAGTTTGCCGCTATGAACGGCGTCACCCTCAAGGGTTTGTCGCGCGAAGACGCGGGCAGCGGCAACAGCCTGTTT
TCGATGGTGCAGATGCTCGCGATCGGCCTCGGCGTGACCATTGGCGGTGGACTCGTGAGTCTGTTCTCGGCCAAGCTTGG
CGTGGCTGCTCCGGCCTATCGGCTGGCCTTCCTCAGTGTGGGCATGATCACGCTGGCGTCGGCCATGGTGTTCCGGCGGC
TCGATGCGGACCTGCTGAACCCGAAGCGGACTGCGGTGGAGGCGCGGTAG

Upstream 100 bases:

>100_bases
CGCAGTCAACAAAGCCAGAGGGGTTCCCGATGGGGTGTCCGCTAGGTACCATGCTCGAACGTCTCCGGGATTACCCGGAC
TGACGCCGCCCCATCAAGAA

Downstream 100 bases:

>100_bases
AGGGCATCGGGGTTGCGGTAAGCGCACGGCTGGGCCGCTCATCCATCGACGGAGATGACCAGCACACCCCGTTCCGACAG
CGCGGGGCGGAGATCGTGCT

Product: EmrB/QacA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MPMRTASASATDQAFSQKAMLWIVFAGFFMQTLDTTIVNTALPAMARSLGEKPLDLKPVVVAYTLTMAMLTPASGWLADR
FGTRRVYFSAILIFVIGSVFCATAHTLTQLVIARVLQGIGGSMLLPIGRLAVLRNIPGEQYIAALAFVSIAGQVGPIFGP
VLGGWLVQSASWHWIFLINVPVGLVGLFAVHRYLPAGEVDAAPPFDWIGCGLLSLCMVTFSLALERGSVSSLSAALMAIS
IASALLYIPHARRHRTPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLFQLQLGYSPFHSGLMLLPVAISGTISK
RWIVPLVNRFGYDIFLLVNTVIVGASIASFAAISPGWPLGLSIVQLAIFGAANSMQFAAMNGVTLKGLSREDAGSGNSLF
SMVQMLAIGLGVTIGGGLVSLFSAKLGVAAPAYRLAFLSVGMITLASAMVFRRLDADLLNPKRTAVEAR

Sequences:

>Translated_469_residues
MPMRTASASATDQAFSQKAMLWIVFAGFFMQTLDTTIVNTALPAMARSLGEKPLDLKPVVVAYTLTMAMLTPASGWLADR
FGTRRVYFSAILIFVIGSVFCATAHTLTQLVIARVLQGIGGSMLLPIGRLAVLRNIPGEQYIAALAFVSIAGQVGPIFGP
VLGGWLVQSASWHWIFLINVPVGLVGLFAVHRYLPAGEVDAAPPFDWIGCGLLSLCMVTFSLALERGSVSSLSAALMAIS
IASALLYIPHARRHRTPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLFQLQLGYSPFHSGLMLLPVAISGTISK
RWIVPLVNRFGYDIFLLVNTVIVGASIASFAAISPGWPLGLSIVQLAIFGAANSMQFAAMNGVTLKGLSREDAGSGNSLF
SMVQMLAIGLGVTIGGGLVSLFSAKLGVAAPAYRLAFLSVGMITLASAMVFRRLDADLLNPKRTAVEAR
>Mature_468_residues
PMRTASASATDQAFSQKAMLWIVFAGFFMQTLDTTIVNTALPAMARSLGEKPLDLKPVVVAYTLTMAMLTPASGWLADRF
GTRRVYFSAILIFVIGSVFCATAHTLTQLVIARVLQGIGGSMLLPIGRLAVLRNIPGEQYIAALAFVSIAGQVGPIFGPV
LGGWLVQSASWHWIFLINVPVGLVGLFAVHRYLPAGEVDAAPPFDWIGCGLLSLCMVTFSLALERGSVSSLSAALMAISI
ASALLYIPHARRHRTPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLFQLQLGYSPFHSGLMLLPVAISGTISKR
WIVPLVNRFGYDIFLLVNTVIVGASIASFAAISPGWPLGLSIVQLAIFGAANSMQFAAMNGVTLKGLSREDAGSGNSLFS
MVQMLAIGLGVTIGGGLVSLFSAKLGVAAPAYRLAFLSVGMITLASAMVFRRLDADLLNPKRTAVEAR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=469, Percent_Identity=42.4307036247335, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1788392, Length=471, Percent_Identity=45.2229299363057, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI1789042, Length=398, Percent_Identity=30.1507537688442, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788710, Length=314, Percent_Identity=32.484076433121, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081983, Length=422, Percent_Identity=27.9620853080569, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788509, Length=137, Percent_Identity=29.9270072992701, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322958, Length=341, Percent_Identity=25.2199413489736, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=154, Percent_Identity=30.5194805194805, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49816; Mature: 49685

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMRTASASATDQAFSQKAMLWIVFAGFFMQTLDTTIVNTALPAMARSLGEKPLDLKPVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
VAYTLTMAMLTPASGWLADRFGTRRVYFSAILIFVIGSVFCATAHTLTQLVIARVLQGIG
HHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSMLLPIGRLAVLRNIPGEQYIAALAFVSIAGQVGPIFGPVLGGWLVQSASWHWIFLINV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEC
PVGLVGLFAVHRYLPAGEVDAAPPFDWIGCGLLSLCMVTFSLALERGSVSSLSAALMAIS
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IASALLYIPHARRHRTPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLFQLQLGY
HHHHHHHCCCHHHHCCHHHHHHEECCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHCCC
SPFHSGLMLLPVAISGTISKRWIVPLVNRFGYDIFLLVNTVIVGASIASFAAISPGWPLG
CCHHCCCEEEEEHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LSIVQLAIFGAANSMQFAAMNGVTLKGLSREDAGSGNSLFSMVQMLAIGLGVTIGGGLVS
HHHHHHHHHCCCCCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHCHHCCHHHHH
LFSAKLGVAAPAYRLAFLSVGMITLASAMVFRRLDADLLNPKRTAVEAR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
PMRTASASATDQAFSQKAMLWIVFAGFFMQTLDTTIVNTALPAMARSLGEKPLDLKPVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
VAYTLTMAMLTPASGWLADRFGTRRVYFSAILIFVIGSVFCATAHTLTQLVIARVLQGIG
HHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSMLLPIGRLAVLRNIPGEQYIAALAFVSIAGQVGPIFGPVLGGWLVQSASWHWIFLINV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEC
PVGLVGLFAVHRYLPAGEVDAAPPFDWIGCGLLSLCMVTFSLALERGSVSSLSAALMAIS
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IASALLYIPHARRHRTPLFRLALFREPNFSVGLVGNLVCRIGSGAVPFLLPLLFQLQLGY
HHHHHHHCCCHHHHCCHHHHHHEECCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHCCC
SPFHSGLMLLPVAISGTISKRWIVPLVNRFGYDIFLLVNTVIVGASIASFAAISPGWPLG
CCHHCCCEEEEEHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
LSIVQLAIFGAANSMQFAAMNGVTLKGLSREDAGSGNSLFSMVQMLAIGLGVTIGGGLVS
HHHHHHHHHCCCCCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHCHHCCHHHHH
LFSAKLGVAAPAYRLAFLSVGMITLASAMVFRRLDADLLNPKRTAVEAR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA