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The map label for this gene is hmyC [H]

Identifier: 94313047

GI number: 94313047

Start: 689926

End: 691308

Strand: Direct

Name: hmyC [H]

Synonym: Rmet_4120

Alternate gene names: 94313047

Gene position: 689926-691308 (Clockwise)

Preceding gene: 94313046

Following gene: 94313048

Centisome position: 26.74

GC content: 67.75

Gene sequence:

>1383_bases
ATGAAGACCAAGAAAACGTTGACTTGGGCCGCCGCGCTGTCGTTGATGAGCGCGCCGGCCTGGGCCGCGCAGCCCGTGCC
GGCCGGCGTTACCGCCGCGCCCGGGGCTGCCTCGCCACAAGCGGCGAAGCTCGCCGCCAAGGCCATGGCGCGCGCTACCA
CGCCAGCCCCCGATACGTTCGACCTGCCGCAGTTGCTGCAACTGGCGCAGTCGACCAACAAGGGCGTGGAAGCCGCGCAG
GCCAATGTGGATGCCGCCACGGCTGCTATTACCAGCGCCCGTGCGTATCCGAACCCGCAGGTGGAAGTGATGTATGGACG
CCTGTCCGGCAAGCAGCCGGGCGTGACCAGCGGCAATGCGCCGTCCTACGCAATCGTCCAGAAACTCGATTACCCGAACC
AGCGCAATCTGCGCGAGCAGATGGCGGGCCGCGGCCTGGAGGCTTCCGAGGCAATGCGGCAAGGCTTCCGCAGTGACCTG
GCCGCGCGCGTGAAGACGTCGTACTACCAGGTGCTTCGCCGCGAGACCGAACTGGCCGCCGCGCGCGAGGACCTGAACAT
GATGCGGCAGATCCAGGAGCGCGCGAAGGTGCGCGTGAACGTCGGCGAGGCCCCGCGCTATGAATTGATCAAGGCCGACA
CGGAACTGCTGGCTGCGCAAAAGACGCTGCAGACGGCGGAGCTGCGCGTCGACCAGGCCAAGGCCACGCTGCGCCAGCAG
GTGGGAGGCGTAATGCCCGCGCGCTTTGCGCTGGACGGCAGCCTCGGGCACGCGCCCGACATGCCTCCGCTGGCAACGTT
GCGCGACACGCTTCAGGCCAGCAATGCGGAACTGACCCAGCGCCGCAGCGAGCTGGAACGCGCGAAGCTGGGCGTGGACT
ACCAGCGCGCGCTGCGCTGGCCCGAGGTGGCGGTGCGTGCCAGCACCGACCGGCAGCCCGACAACAATGTTTCGCAGATC
GGCCTGGTGATGACGATTCCGATCTGGGATCGCCGCAGCGGCCCGGTGGGCGAGGCGACGGCGCAGGCCACGCAGGCCCG
CACGGCGCTCGAAGCGCGTGAATTCGAGTTGATGCAGGAACTCGACACCGCCTATCGCCAATACGAGATCGCGCAGGCCC
AGGTGACGGCGCTGGAATCGGGCATCGTGCGCGAGGCCGAGTCGGCCTTGGGCGTGGCCGAATCCGCCTATCGCTTTGGC
GAGCGCGGCATTCTCGACTACCTCGACGCCCAGCGCGTGCTGCGTAGCGCGCGCAGCGAGTTGATTGCCGCGCAATACGA
ACTGCAAGTCGCCGCCATCCAGATTGACAAGCTCATGTCGGCCTCGCCGGGCGTCAATACCGCCCCTGCGTCGTCCATGC
CCGACCTCCCGAATCTGAACTGA

Upstream 100 bases:

>100_bases
CATGCGTGCCCGCCTGCCGAACGATGTCCGGTGGCGGGGCGTGTGACGGGAAGCGTGTGTGTAGGCGCCGGGGCAGTCGT
GCCGTTCGACCGATCCTGAC

Downstream 100 bases:

>100_bases
TCATGCGTCCCCAATTCCTGCTTTCCTTTGCAGCCGCCGCCGTGATGATGCTGTCGCTGGCCGGCTGTTCCGATGACCCC
GCCCCGGCCGCCGAGGCGCC

Product: heavy metal cation tricomponent efflux outer membrane porin HmyC

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKTKKTLTWAAALSLMSAPAWAAQPVPAGVTAAPGAASPQAAKLAAKAMARATTPAPDTFDLPQLLQLAQSTNKGVEAAQ
ANVDAATAAITSARAYPNPQVEVMYGRLSGKQPGVTSGNAPSYAIVQKLDYPNQRNLREQMAGRGLEASEAMRQGFRSDL
AARVKTSYYQVLRRETELAAAREDLNMMRQIQERAKVRVNVGEAPRYELIKADTELLAAQKTLQTAELRVDQAKATLRQQ
VGGVMPARFALDGSLGHAPDMPPLATLRDTLQASNAELTQRRSELERAKLGVDYQRALRWPEVAVRASTDRQPDNNVSQI
GLVMTIPIWDRRSGPVGEATAQATQARTALEAREFELMQELDTAYRQYEIAQAQVTALESGIVREAESALGVAESAYRFG
ERGILDYLDAQRVLRSARSELIAAQYELQVAAIQIDKLMSASPGVNTAPASSMPDLPNLN

Sequences:

>Translated_460_residues
MKTKKTLTWAAALSLMSAPAWAAQPVPAGVTAAPGAASPQAAKLAAKAMARATTPAPDTFDLPQLLQLAQSTNKGVEAAQ
ANVDAATAAITSARAYPNPQVEVMYGRLSGKQPGVTSGNAPSYAIVQKLDYPNQRNLREQMAGRGLEASEAMRQGFRSDL
AARVKTSYYQVLRRETELAAAREDLNMMRQIQERAKVRVNVGEAPRYELIKADTELLAAQKTLQTAELRVDQAKATLRQQ
VGGVMPARFALDGSLGHAPDMPPLATLRDTLQASNAELTQRRSELERAKLGVDYQRALRWPEVAVRASTDRQPDNNVSQI
GLVMTIPIWDRRSGPVGEATAQATQARTALEAREFELMQELDTAYRQYEIAQAQVTALESGIVREAESALGVAESAYRFG
ERGILDYLDAQRVLRSARSELIAAQYELQVAAIQIDKLMSASPGVNTAPASSMPDLPNLN
>Mature_460_residues
MKTKKTLTWAAALSLMSAPAWAAQPVPAGVTAAPGAASPQAAKLAAKAMARATTPAPDTFDLPQLLQLAQSTNKGVEAAQ
ANVDAATAAITSARAYPNPQVEVMYGRLSGKQPGVTSGNAPSYAIVQKLDYPNQRNLREQMAGRGLEASEAMRQGFRSDL
AARVKTSYYQVLRRETELAAAREDLNMMRQIQERAKVRVNVGEAPRYELIKADTELLAAQKTLQTAELRVDQAKATLRQQ
VGGVMPARFALDGSLGHAPDMPPLATLRDTLQASNAELTQRRSELERAKLGVDYQRALRWPEVAVRASTDRQPDNNVSQI
GLVMTIPIWDRRSGPVGEATAQATQARTALEAREFELMQELDTAYRQYEIAQAQVTALESGIVREAESALGVAESAYRFG
ERGILDYLDAQRVLRSARSELIAAQYELQVAAIQIDKLMSASPGVNTAPASSMPDLPNLN

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 49795; Mature: 49795

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKKTLTWAAALSLMSAPAWAAQPVPAGVTAAPGAASPQAAKLAAKAMARATTPAPDTF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
DLPQLLQLAQSTNKGVEAAQANVDAATAAITSARAYPNPQVEVMYGRLSGKQPGVTSGNA
CHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
PSYAIVQKLDYPNQRNLREQMAGRGLEASEAMRQGFRSDLAARVKTSYYQVLRRETELAA
CCHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREDLNMMRQIQERAKVRVNVGEAPRYELIKADTELLAAQKTLQTAELRVDQAKATLRQQ
HHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGGVMPARFALDGSLGHAPDMPPLATLRDTLQASNAELTQRRSELERAKLGVDYQRALRW
HCCCCCHHEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCCC
PEVAVRASTDRQPDNNVSQIGLVMTIPIWDRRSGPVGEATAQATQARTALEAREFELMQE
CHHEEECCCCCCCCCCHHHEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDTAYRQYEIAQAQVTALESGIVREAESALGVAESAYRFGERGILDYLDAQRVLRSARSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LIAAQYELQVAAIQIDKLMSASPGVNTAPASSMPDLPNLN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTKKTLTWAAALSLMSAPAWAAQPVPAGVTAAPGAASPQAAKLAAKAMARATTPAPDTF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
DLPQLLQLAQSTNKGVEAAQANVDAATAAITSARAYPNPQVEVMYGRLSGKQPGVTSGNA
CHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
PSYAIVQKLDYPNQRNLREQMAGRGLEASEAMRQGFRSDLAARVKTSYYQVLRRETELAA
CCHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREDLNMMRQIQERAKVRVNVGEAPRYELIKADTELLAAQKTLQTAELRVDQAKATLRQQ
HHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGGVMPARFALDGSLGHAPDMPPLATLRDTLQASNAELTQRRSELERAKLGVDYQRALRW
HCCCCCHHEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCCC
PEVAVRASTDRQPDNNVSQIGLVMTIPIWDRRSGPVGEATAQATQARTALEAREFELMQE
CHHEEECCCCCCCCCCHHHEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDTAYRQYEIAQAQVTALESGIVREAESALGVAESAYRFGERGILDYLDAQRVLRSARSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LIAAQYELQVAAIQIDKLMSASPGVNTAPASSMPDLPNLN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]